Results 211 to 220 of about 6,026 (227)

EMITT-1: Proof-of-mechanism immunopeptidome (ImPD) effects at target PK exposure, in a phase 1 study of GRWD5769 (a first-in-class inhibitor of Endoplasmic Reticulum Aminopeptidase 1 [ERAP1]) in patients with solid malignancies.

Journal of Clinical Oncology
2589 Background: GRWD5769 is a first-in-class, orally bioavailable ERAP1 inhibitor that significantly modulates the peptide repertoire displayed on MHC-1 on tumor cells, driving novel T cell response and causing tumor cell killing in preclinical studies.
Thomas Lillie, G. Kichenadasse, J. Liu, Tatiana Hernández Guerrero, E. Calvo, Haakan Jakobsson, V. Moreno, H. K. Gan, P. Joyce, N. Hyland, M. Giovannetti, T. Palmer, C. McAlpine, Daniel Green, S. Symeonides   +14 more
semanticscholar   +1 more source

Modulation of antigen presentation by first-in-class ERAP1 and ERAP2 inhibitors for the treatment of cancer and autoimmunity

Journal of Immunology
The aminopeptidases ERAP1 and ERAP2 play a central role in the processing of antigens for loading onto MHC-I complexes with links to both autoimmunity and cancer.
Kristopher Clark, Kate Anderton, Wayne Paes, Daniel Green, F. Khan, Nicola Ternette, T. Lam, J. Wat, Maaike Bras, Tobias Trelber, Anamarija Pfeiffer, Daniel Redfern, Annaig Rozo, Joud Sabouni, Samantha Garside, S. Kay, J.S.H. Shiers   +16 more
semanticscholar   +1 more source

P18 Genome-wide meta-analysis identifies ERAP1 in epistasis with MHC class I alleles in frontal fibrosing alopecia

British Journal of Dermatology
Frontal fibrosing alopecia (FFA) is a scarring, inflammatory form of hair loss that predominantly affects postmenopausal women and has become more prevalent in recent years.
T. Rayinda, Nick Dand, S. McSweeney, E.A.A. Christou, Chuin Yin Ung, C. Stefanato, D. Fenton, John A. McGrath, Michael A. Simpson, C. Tziotzios   +9 more
semanticscholar   +1 more source

ERAP1 Gen İfadesinin Plazma Hücre Diskrazilerinde İncelenmesi

İSTANBUL KANUNİ SULTAN SÜLEYMAN TIP DERGİSİ, 2022
openaire   +1 more source

Corilagin regulates antigen processing and presentation by directly binding to inhibit ERAP1.

International Immunopharmacology
Xiangcheng Sun, Yuxin Zhou, Shuangning Yu, Xiaofan Liu, Jiaqi Wu, Yan Zhou, Jiao Bai, Dahong Li, Huji Xu, Hao Cao   +9 more
semanticscholar   +1 more source

Discovery of an orally available potent ER aminopeptidase 1 (ERAP1) inhibitor that enhances anti-tumor responses and limits inflammatory autoimmunity in vivo

bioRxiv
Christopher Tinworth, Justyna Wojno-Picon, Michael J. Adam, Stephan Gade, A. P. Hancock, David J. Hirst, Jonathan P. Hutchinson, Semra J. Kitchen, Despoina Koumantou, Jonathan D. Lea, Stephanie Lehmann, John Liddle, Richard Lonsdale, Margarete Neu, Leng Nickels, Alexander N. Phillipou, J. Rowedder, Paul Rowland, Jessica L. Schneck, Paul T. Scott-Stevens, Hester Sheehan, Michael Steidel, Chloe L. Tayler, Ioannis Temponeras, Kevin Thang, David F Tough, Giovanni Vitulli, Ian D. Wall, R. Young, Nico Zinn, Simon Peace, E. Stratikos   +31 more
semanticscholar   +1 more source

INVESTIGATIONS INTO THE IMMUNOMODULATORY PROPERTIES OF SLAMF7 AND ERAP1

2021
openaire   +1 more source

RARE ERAP1 ALLOTYPE COMBINATIONS DO NOT EXPLAIN THE ERAP1 ASSOCIATION WITH ANKYLOSING SPONDYLITIS

ANNALS OF THE RHEUMATIC DISEASES
Appleton, L. H.; Roberts, A. R.; Vecellio, M.; Wordsworth, B. P.   +4 more
openaire   +1 more source

Targeting ERAP1 to disarm Gli activation in Sonic Hedgehog medulloblastoma.

Molecular Therapy
Guo Shi, E. Zeqiraj, Natalia A. Riobo-Del Galdo   +2 more
semanticscholar   +1 more source

POS0879 ERAP1 POLYMORPHISMS AND THEIR ROLE IN MODULATING DISEASE RISK AMONG FIRST-DEGREE RELATIVE OF HLA-B27 POSITIVE SPONDYLOARTHRITIS PATIENTS

Annals of the Rheumatic Diseases
V. Koneru, M. Mary Thabah, C. Mary, Csaky Kg, R. R, L. K, A. José, J.B. Kuduva Loganathan, S. Philip, R. Mishra, R. Naushad, G. K   +11 more
semanticscholar   +1 more source