Results 171 to 180 of about 2,212 (246)
Advanced Science, EarlyView.During NETosis, neutrophils shift metabolically toward enhanced OXPHOS and partially reduced glycolysis. This shift is driven by PDHA1 hyperactivity‐dependent selective metabolic reprogramming. The neutrophil‐targeted nanoparticle 3‑FP‑BSA NPs effectively inhibit NETosis and attenuate ALI.
Yu‐Biao Liu +14 more
wiley +1 more source
Advanced Science, EarlyView.Mitochondrial quality control (MQC) collapse redefines osteoarthritis, intervertebral disc degeneration, and osteoporosis as disorders of organelle dysfunction. Damaged mitochondria leak mtDNA and metabolites, driving cGAS‐STING inflammation, epigenetic reprogramming, and metabolic memory.
Haiyang Gao +7 more
wiley +1 more source
Advanced Science, EarlyView.FDA‐approved anti‐inflammatory drug Auranofin inhibits SARS‐CoV‐2 replication by inhibiting viral Main protease activity and Spike processing required for viral entry. It shows strong synergy with nucleoside analogue Remdesivir, due to non‐overlapping mechanisms.
Oyahida Khatun +13 more
wiley +1 more source
Advanced Science, EarlyView.A dual‐track time‐resolved encryption strategy with independent information display during photo‐bleaching and thermal‐recovery stages has been realized through multiple temporal encoding units derived from orthogonal covalent‐noncovalent programming of donor–acceptor Stenhouse adduct photoswitching.
Qi Guo +11 more
wiley +1 more source
Advanced Science, EarlyView.In collagen‐induced arthritis (CIA) mice, increased CD4+ T cell accumulation in the spinal dorsal horn induces pain hypersensitivity. Mechanistically, PKM2‐mediated H3K9 lactylation and XBP1 signaling positive feedback loop facilitates CD4+ T cell spinal migration and induces central sensitization‐like behaviors in CIA mice.
Yuepeng Jiang +10 more
wiley +1 more source
Photo‐Induced Stepwise Liquid Crystal Phase Transition Enabled by Hydrazone Photoswitch
Advanced Science, EarlyView.A judiciously designed bistable hydrazone photoswitch enables a photo‐induced stepwise “order‐disorder” phase transition in liquid crystals. The linear‐to‐bent isomerization disrupts molecular packing, allowing precise tuning of phase transition temperatures.
Shijie Liu +11 more
wiley +1 more source
Advances in Josephson Junction Materials and Processes Toward Practical Quantum Computing
Advanced Science, EarlyView.Emerging materials for quantum computing, including crystalline materials, two‐dimensional van der Waals materials, two‐dimensional electron gas systems, ferromagnets, and unconventional (e.g., d‐wave) superconductors, offer opportunities to engineer next‐generation Josephson junctions.
Hyunseong Kim +11 more
wiley +1 more source
Highly Linear Perovskite Synapses for Neuromorphic Computing
Advanced Science, EarlyView.Voltage spikes applied to an Au/ACI‐phase perovskite/ITO memristor emulate the ionic signaling of a biological synapse, generating a tunable postsynaptic current. The vertically aligned perovskite film confines iodide‐vacancy migration, enabling highly linear, and symmetric conductance updates with 100 states and 5.5 aJ per event. Such synapses sustain
Zhongwen Sun +7 more
wiley +1 more source