Results 121 to 130 of about 58,467 (222)
CMBs carrying PTX and CRISPR/Cas9 targeting C‑erbB‑2 plasmids interfere with endometrial cancer cells. [PDF]
Peng S, Cai J, Bao S.
europepmc +1 more source
An uncommon subtype of breast carcinoma in a man: The pure mucinous carcinoma [PDF]
Aim: Our purpose is to describe a new case of pure mucinous carcinoma in a man, to put emphasis on the rarity of this histologic subtype and the problems of management due to the fewer reported cases in the literature and to compare it with the female ...
Sawssen Dhambri , Mona Mlika , Aïda Ayadi-Kaddour , Abdelfattah Zeddini , Faouzi El Mezni , Int J Cur Biomed Phar Res.
core
ABSTRACT Background Real‐world evidence regarding the use of dacomitinib as a first‐line therapy for advanced non‐small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations remains limited. This multicenter, retrospective cohort study aimed to evaluate the clinical outcomes of dacomitinib as a first‐line treatment in patients
Ping‐Chih Hsu +9 more
wiley +1 more source
We developed three UC clusters, applicable for MIBC and NMIBC, which were validated using transcriptomic- and proteomic datasets. Publically available UC cell lines were assigned to the clusters, to have in vitro models representing each cluster. The clusters differ in molecular and biological signatures, with distinct prognostic and therapeutic ...
Nils C. H. van Creij +17 more
wiley +1 more source
BackgroundThere is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Inka Regine Weingaertner +2 more
doaj +1 more source
ABSTRACT Aim The genetic loci, ERBB2/IKZF3/GSDMB/ORMDL3 on chromosome 17q, and ERBB3/IKZF4 on chromosome 12q represent confirmed non‐HLA risk factors for the development of autoimmunity and progression to type 1 diabetes (T1D). It is unknown whether both regions can interact to influence the progression of T1D.
Ina M. Mertens +4 more
wiley +1 more source
Companion Diagnostics in Clinical Therapy: Current Applications and Future Directions
Companion diagnostics use biomarker‐based assays to stratify patients for precision therapies, improving outcomes while reducing ineffective treatment and side effects. This review summarizes the evolution, regulatory landscape, clinical applications, and technological platforms of CDx, highlighting their role in biomarker‐driven precision therapy.
Yuesong Wu +9 more
wiley +1 more source
Predictive value of her-2 in breast cancer: Chemotherapy [PDF]
Stamatović Ljiljana +5 more
doaj +1 more source
Nuclear and Cytoplasmic Expression of ErbB-4 in Prostate Cancer
Purpose To evaluate cytoplasmic and nuclear ErbB-4 expression in prostate cancer specimens and its association with outcome. Basic procedures Specimens of 50 prostate cancer patients were investigated for ErbB-4 overexpression using immunohistochemistry ...
R. Ben-Yosef +7 more
doaj +1 more source
Cancer remains the leading cause of mortality worldwide, and drug resistance further underscores the urgent need for innovative therapeutic strategies. Chromatin, a stable yet highly dynamic nucleoprotein complex, serves as the primary carrier of genetic material in eukaryotic cells.
Wentao Xia +4 more
wiley +1 more source

