Results 11 to 20 of about 44,831 (130)

Ultrasound microbubble-mediated CRISPR/Cas9 knockout of in HEC-1A cells [PDF]

Journal of International Medical Research, 2019
Objective Epidermal growth factor receptor 2 (C-erbB-2) is one of the most frequently mutated oncogenes in human tumors. We aimed to evaluate the knockout efficiency of clustered regularly interspaced short palindromic repeat (CRISPR) technology using ...
Junhong Cai, Sizhe Huang, Yuping Yi, Shan Bao   +3 more
doaj   +2 more sources

Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas [PDF]

Breast Cancer Research, 2019
Background ERBB-2 is overexpressed in about 20% of breast cancers (BCs), indicating poor prognosis. The receptor activator of nuclear factor-κB (RANK) pathway is implicated in ERBB-2 (+) BC.
Ilianna Zoi, Michalis V. Karamouzis, Evangelia Xingi, Panagiotis Sarantis, Dimitra Thomaidou, Panayiotis Lembessis, Stamatios Theocharis, Athanasios G. Papavassiliou   +7 more
doaj   +2 more sources

Skor Histologi C-Erbb-2, Proliferasi Endotel Pembuluh Darah: Pada Infiltrasi Levobupivakain Terhadap Penyembuhan Luka

JAI (Jurnal Anestesiologi Indonesia), 2009
Latar Belakang: Nyeri akut paska bedah memicu timbulnya gejala klinis patofisiologis, menekan respon imun, sehingga menyebabkan penurunan sistem imun yang akan menghambat penyembuhan luka. Levobupivakain, anestetik lokal durasi panjang efektif mengurangi
Curniawati Trisasi, Marwoto Marwoto
doaj   +1 more source

Correlation of c-erbB-2, EGF and EGFR expression with postoperative survival of patients with advanced carcinoma of the stomach.

Folia Histochemica et Cytobiologica, 2010
The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz, Jolanta Czyzewska, Andrzej Kemona   +2 more
doaj   +1 more source

C-erbB-2 in Serum of Patients with Breast Cancer

The International Journal of Biological Markers, 1999
c-erbB-2 is an oncoprotein which is overexpressed in some breast cancers. Recently it has been established that the extracellular domain of c-erbB-2 is shed into the serum of patients with breast cancer.
L. Harris, D. Luftner, W. Jäger, J.F.R Robertson   +3 more
doaj   +1 more source

Expressão da proteína erbB-2 e dos receptores de hormônios na transição das regiões in situ para invasora de tumores da mama ErbB-2 expression and hormone receptor status in areas of transition from in situ to invasive ductal breast carcinoma

Revista Brasileira de Ginecologia e Obstetrícia, 2009
OBJETIVOS: avaliar a expressão de erbB-2 e dos receptores hormonais para estrógeno e progesterona (RE/RP) nas regiões de transição entre as frações in situ e invasoras de neoplasias ductais da mama (CDIS e CDI, respectivamente).
Raquel Mary Rodrigues Peres, Sophie Françoise Mauricette Derchain, Juliana Karina Ruiz Heinrich, Kátia Piton Serra, Glauce Aparecida Pinto, Fernando Augusto Soares, Luís Otávio Zanatta Sarian   +6 more
doaj   +1 more source

p38MAPK Induces Cell Surface α4 Integrin Downregulation to Facilitate erbB-2-Mediated Invasion

Neoplasia: An International Journal for Oncology Research, 2003
We have previously shown that human breast cancer cells that overexpress erbB-2 are growth factorindependent. In order to test the contribution of erbB2 to this and other transformed phenotypes without the genetic instability of cancer cells, erbB-2 was ...
Kathleen M. Woods Ignatoski, Navdeep K. Grewal, Sonja Markwart, Donna L. Livant, Stephen P. Ethier   +4 more
doaj   +1 more source

Elastosis in Breast Cancer as a Surrogate Marker for Estrogen Receptor Positivity

Oman Medical Journal, 2021
Objectives: We sought to describe the occurrence of stromal elastosis in breast carcinoma among Omani female patients using semi-quantitative methods.
Samah Al Abri, Abdulhakeem Al Rawahi, Lakshmi Rao   +2 more
doaj   +1 more source

Detection of c-erbB-2 mRNAs Using Dig-Labelled Oligonucleotide Probe with in situ Hybridisation in Human Breast Carcinoma: Comparison with Immunohistochemical Results

Analytical Cellular Pathology, 1998
Amplification and overexpression of the c-erbB-2 oncogene are of prognostic significance in human breast cancer. Overexpression of c-erbB-2 is the result of gene amplification.
Melek Öztürk, Sema Bolkent, Selma Yilmazer, Gültekin Kaner, Hilal Ünal   +4 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source