Results 211 to 220 of about 58,467 (222)

Eradication of c- erbB-2-Positive Ovarian Cancer Cells Mediated by Intracellular Expression of Anti-c- erbB-2 Antibody

2003
Overexpression of erbB-2 is important in the pathogenesis of a variety of human neoplasms. Overexpression of the erbB-2 gene product has been associated with poor clinical prognosis with respect to malignancies originating in the ovary, breast, gastrointestinal tract, salivary gland, and lung (1-4) and has led to the development of several therapeutic ...
J, Deshane, R D, Alvarez, G P, Siegal
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Shc products are substrates of erbB-2 kinase.

Oncogene, 1993
The shc genes encodes three widely expressed proteins of 46, 52 and 66 kDa. Overexpression of p46shc and p52shc in NIH3T3 fibroblasts induces a tumorigenic phenotype. Shc products are phosphorylated on tyrosine by the activated epidermal growth factor receptor (EGFR) and become physically associated with EGFR via their SH2 domain. Thus Shc oncoproteins
O. Segatto, G. Pelicci, S. Giuli, G. Digiesi, P. P. Di Fiore, J. McGlade, T. Pawson, P. G. Pelicci   +7 more
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Regulation of ErbB-2 Metabolic Stability

2004
Abstract : This grant has focused on the mechanism by which geldanamycin controls the metabolic stability of ErbB-2, a co-receptor tyrosine kinase. ErbB-2 is overexpressed in breast cancer and is known to increase cell proliferation. Geldanamycin decreases ErbB-2 levels in cells and is in clinical trials for the treatment of breast cancer.
openaire   +1 more source

erbB-2 gene expression in colorectal cancer.

The Japanese journal of experimental medicine, 1991
The expression of the erbB-2 gene product was studied immunohistochemically on 38 normal colonic mucosae, 14 adenomas and 44 colon cancers, with the use of two anti-erbB-2 antibodies, a rabbit polyclonal antibody specific for the intracellular domain and a mouse monoclonal antibody specific for the extracellular domain. Normal mucosae and adenomas were
G J, Tsioulias, T, Muto, Y, Morioka, T, Yamamoto, S, Mori   +4 more
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c‐erbB‐2 proto‐oncogene product

Histopathology, 1990
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Mide kanserli hastalarda ErbB-2 overekspresyonunun araştırılması

2020
In this study, the prevalence of ErbB-2 overexpression in gastric cancer and its relationship with pathologic parameters were investigated.Newly diagnosed 32 patients from Internal Medicine and General Surgery Clinics of Ataturk University were included. DNA isolation of the patients who were diagnosed as gastric adenocarcinoma by endoscopic biopsy has
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Anti-erbB-2

2016
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HER2/ErbB-2/Neu

1997
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Intracellular single-chain antibody directed against ERBB-2 down-regulates cell surface ERBB-2 and selectively eradicates ERBB-2 over-expressing cancer cell lines

Journal of the Society for Gynecologic Investigation, 1995
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Anthracyclines/ERBB-2-receptor-antagonists

Reactions Weekly
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