Results 41 to 50 of about 44,831 (130)
Animal Research and One Health, EarlyView.ABSTRACT This study explored fasting‐induced physiological remodeling effects on meat quality in aged laying hens. Fasting for 15 days (F15) significantly reduced abdominal fat, intermuscular fat width, subcutaneous fat thickness, and liver index versus pre‐fasting (F0) (p < 0.05), which recovered post‐refeeding.
Xiaoran Zhang +8 more
wiley +1 more source
Limited Prognostic Value of c-erbB-2 Compared to uPA and PAI-1 in Primary Breast Carcinoma
The International Journal of Biological Markers, 2003 In a retrospective study of 488 women with primary breast cancer, after a median follow-up of 10 years, we sought interactions between disease-free survival (DFS) and overall survival (OS) and tumor antigen levels of two components of the plasminogen ...
C. Bouchet +4 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.We assembled National Cancer Center–Clinical Diagnostics Knowledgebase, a clinical genomic knowledgebase of 6935 tumors with matched normal samples, revealing key somatic alterations and actionable variants (70.2% of the cohort). Enrichment of certain different gene mutations was observed between Chinese and American populations, along with a strong ...
Hongrui Li +10 more
wiley +1 more source
ChemistryOpen, EarlyView.New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha +6 more
wiley +1 more source
Pediatric Discovery, EarlyView.ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang +4 more
wiley +1 more source
乳腺浸润性导管癌c-erbB-2的表达与淋巴结转移和肿瘤细胞分裂能力的关系
Zhongguo shiyan zhenduanxue, 2005 目的探讨乳腺浸润性导管癌中c-erbB-2与肿瘤生物学特性的关系。方法应用免疫组化SP方法对检测乳腺浸润性导管癌c-erbB-2的表达情况极其淋巴结转移和癌细胞分裂能力的相关性。结果c-erbB-2阳性表达主要分布在肿瘤细胞的胞膜上;随着c-erbB-2表达强度的降低,肿瘤淋巴结转移率呈减少的趋势;肿瘤组织中细胞的核分裂数目随着c-erbB-2的表达强度增加而增多。结论c-erbB-2是乳腺癌细胞增殖、转移能力和预后判定的参考指标。
王勇 +5 more
doaj
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Cancer Science, EarlyView.Using a machine learning–based approach in a multi‐institutional prospective cohort, we identified a robust miRNA signature that demonstrated high diagnostic accuracy for esophageal squamous cell carcinoma. Our 57‐miRNA panel achieved an AUC of 0.90 in the proof‐of‐concept cohort and 0.85 in an independent validation cohort, with a sensitivity of 84 ...
Tatsuro Murano +14 more
wiley +1 more source
Genetic alterations in benign, preneoplastic and malignant breast lesions
Indian Journal of Pathology and Microbiology, 2012 Context: The c-erbB-2 proto-oncogene is a member of the epidermal growth factor receptor family and has been associated with a more aggressive breast tumor biology and resistance to some types of treatments.
Mehmet Esref Kabalar +4 more
doaj +1 more source
Cancer Science, EarlyView.Mass spectrometry‐based phosphoproteomics for mechanistic dissection of cancer signaling pathways and uncovering therapeutic vulnerabilities. ABSTRACT Protein phosphorylation is a central post‐translational modification regulating cellular signaling, frequently dysregulated in cancer.
Hirokazu Shoji +2 more
wiley +1 more source