Results 61 to 70 of about 58,467 (222)

Alterations of c-Myc and c-erbB-2 genes in ovarian tumours [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2009
Introduction. According to clinical and epidemiological studies, ovarian cancer ranks fifth in cancer deaths among women. The causes of ovarian cancer remain largely unknown but various factors may increase the risk of developing it, such as age, family ...
Pastor Tibor, Popović Branka, Gvozdenović Ana, Boro Aleksandar, Petrović Bojana, Novaković Ivana, Puzović Dragana, Luković Ljiljana, Milašin Jelena   +8 more
doaj   +1 more source

Broadening of Epitope Recognition During Immune Rejection of ErbB-2-Positive Tumor Prevents Growth of ErbB-2-Negative Tumor [PDF]

The Journal of Immunology, 2003
Abstract Tumor heterogeneity is a limiting factor in Ag-specific vaccination. Ag-negative variants may arise after tumor cells bearing the immunizing Ags are destroyed. In situ priming to tumor-associated epitopes distinct from and not cross-reactive with the immunizing Ags may be crucial to the ultimate success of cancer vaccination ...
Shari A, Pilon, Carmen, Kelly, Wei-Zen, Wei   +2 more
openaire   +2 more sources

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Epidermal Growth Factor Receptor and c-erbB-2 Contents in Unresectable (UICC R1 or R2) Gastric Cancer

The International Journal of Biological Markers, 2003
Background Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis.
I. García, J.M. Del Casar, M.D. Corte, M.T. Allende, J.L. García-Muñiz, F. Vizoso   +5 more
doaj   +1 more source

Phage display peptides for breast cancer targeting [PDF]

The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf ...
Bates, Maura K.
core   +1 more source

Metastatic cancer cells from c-erbB-2 negative primary breast cancer maintain the original c-erbB-2/HIF1α phenotype [PDF]

Cancer Biology & Therapy, 2007
The expression of c-erbB-2 and HIF1alpha proteins is linked with an aggressive tumor phenotype and poor survival in breast cancer. In the present study we investigated whether this ominous effect is a result of c-erbB-2/HIF1alpha expressing clone appearance within the primary tumor, by examining the c-erbB-2/HIF1alpha expression status in the primary ...
Alexandra, Giatromanolaki, Michael I, Koukourakis, Costantinos, Simopoulos, Efthimios, Sivridis   +3 more
openaire   +2 more sources

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

C-erbB-2 as a Biomarker for Premalignant Potential of Oral Lichen Ruber [PDF]

, 2004
Ovim istraživanjem nastojao se procijeniti mogući premaligni potencijal lezija oralnoga lihen rubera (OLR-a) određivanjem intenziteta ekspresije tkivnog antigena c-erbB-2 u odnosu prema kliničkom obliku i kliničkom statusu lezija.
Ahmed Pirkić, Ana Cekić-Arambašin, Dolores Biočina-Lukenda   +2 more
core   +1 more source

Breast cancer receptor status assessment and clinicopathological association in Nigerian women: A retrospective analysis [PDF]

, 2014
Background: Breast cancer markers are becoming increasingly important in breast cancer research due to their impact on prognosis, treatment and survival.
Ayodele, Sanni D., Javid, Farideh A., Makanjuola, Samira B.L., Obafunwa, John O., Oludara, Mobolaji A, Popoola, Abiodun O.   +5 more
core   +1 more source

ErbB-2 Amplification Inhibits Down-regulation and Induces Constitutive Activation of Both ErbB-2 and Epidermal Growth Factor Receptors [PDF]

Journal of Biological Chemistry, 1999
ErbB-2/HER2 is an important signaling partner for the epidermal growth factor receptor (EGFR). Overexpression of erbB-2 is also associated with poor prognosis in breast cancer. To investigate how erbB-2 amplification affects its interactions with the EGFR, we used a human mammary epithelial cell system in which erbB-2 expression was increased 7-20-fold
R, Worthylake, L K, Opresko, H S, Wiley
openaire   +2 more sources