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The deaf and the dumb: the biology of ErbB-2 and ErbB-3
Experimental Cell Research, 2003ErbB-2 (also called HER2/neu) and ErbB-3 are closely related to the epidermal growth factor receptor (EGFR/ErbB-1), but unlike EGFR, ErbB-2 is a ligandless receptor, whereas ErbB-3 lacks tyrosine kinase activity. Hence, both ErbB-2 and ErbB-3 are active only in the context of ErbB heterodimers, and ErbB-2.
Ami, Citri +2 more
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Epiregulin binds to epidermal growth factor receptor and ErbB-4 and induces tryosine phosphorylation of epidermal growth factor receptor, ErbB-2, ErbB-3 and ErbB-4 [PDF]
Oncogene, 1997 Epiregulin is a member of the epidermal growth factor (EGF) family, and has certain characteristics that are different from that of EGF, including mitogenic responses and binding to EGF receptor (EGFR). Epiregulin may also have another cell surface receptor and/or induces different receptor heterodimerizations for intracellular signaling.
Toshi Komurasaki, T Komurasaki
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Experimental Cell Research, 2009
Lung cancer remains the leading cause of cancer deaths worldwide, and advanced stage disease is largely refractory to conventional chemotherapy. Thus, there is an important need for alternative treatment strategies, and the ErbB proteins have emerged as potentially important therapeutic drug targets in this setting, apparently reflecting a state of ...
Sreenath V, Sharma, Jeffrey, Settleman
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Lung cancer remains the leading cause of cancer deaths worldwide, and advanced stage disease is largely refractory to conventional chemotherapy. Thus, there is an important need for alternative treatment strategies, and the ErbB proteins have emerged as potentially important therapeutic drug targets in this setting, apparently reflecting a state of ...
Sreenath V, Sharma, Jeffrey, Settleman
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ErbB‐3 and ErbB‐4 Expression in the Mouse Olfactory Systema
Annals of the New York Academy of Sciences, 1998ABSTRACT: The interplay between neuregulins and the ErbB receptor family has a pivotal role in the development of several tissues, including the nervous system, and is maintained in the adult olfactory system where extensive plasticity and neurogenesis are retained.
I. Perroteau +4 more
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American Journal of Respiratory Cell and Molecular Biology, 1999
Abstract This article examines differential expression and heterodimer formation of ErbB family members in tumorigenic and nontumorigenic human bronchial epithelial cells (HBECs). This cell system was developed previously as a model for lung adenocarcinoma by overexpression of c-erbB-2 in nontumorigenic, T antigen–immortalized HBECs ...
A M, Fernandes +2 more
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Abstract This article examines differential expression and heterodimer formation of ErbB family members in tumorigenic and nontumorigenic human bronchial epithelial cells (HBECs). This cell system was developed previously as a model for lung adenocarcinoma by overexpression of c-erbB-2 in nontumorigenic, T antigen–immortalized HBECs ...
A M, Fernandes +2 more
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Untangling the ErbB signalling network
Nature Reviews Molecular Cell Biology, 2001When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion. The network is often dysregulated in cancer and lends credence to the mantra that molecular understanding yields clinical benefit: over ...
Yosef Yarden +2 more
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Experimental Cell Research, 2003
Members of the ErbB (epidermal growth factor receptor) family of receptor tyrosine kinases are important in etiology of human mammary carcinoma, and are rational targets for cancer therapy. The frequent selection of ErbB2/HER2/Neu, and, less often, the epidermal growth factor receptor, and ErbB3 for overexpression in breast cancer implies that these ...
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Members of the ErbB (epidermal growth factor receptor) family of receptor tyrosine kinases are important in etiology of human mammary carcinoma, and are rational targets for cancer therapy. The frequent selection of ErbB2/HER2/Neu, and, less often, the epidermal growth factor receptor, and ErbB3 for overexpression in breast cancer implies that these ...
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Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines
Cancer Immunology, Immunotherapy, 2002The tumour antigen ErbB-2 belongs to the epidermal growth factor receptor family. Numerous studies have shown that ErbB-2 is overexpressed in many cancers and it is prognostically important in a subset of malignancies. It is well recognised that this receptor has many characteristics that make it an excellent target for tumour-specific immunotherapy ...
Yip, Yum L., Ward, Robyn L.
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Science Signaling, 2000
Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
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Olayioye et al . have written a review on the ErbB receptors and their ligands. The review covers how receptor homo- and heterodimerization contribute to signaling complexity and specificity.
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Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland
Journal of Mammary Gland Biology and Neoplasia, 1997ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a kinase. Heregulin serves as a ligand for both receptors.
K L, Carraway +2 more
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