Results 11 to 20 of about 95,906 (268)

ErbB-2 expression and hormone receptor status in areas of transition from in situ to invasive ductal breast carcinoma [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2009
OBJETIVOS: avaliar a expressão de erbB-2 e dos receptores hormonais para estrógeno e progesterona (RE/RP) nas regiões de transição entre as frações in situ e invasoras de neoplasias ductais da mama (CDIS e CDI, respectivamente).
DERCHAIN, Sophie Françoise Mauricette, HEINRICH, Juliana Karina Ruiz, PERES, Raquel Mary Rodrigues, PINTO, Glauce Aparecida, SARIAN, Luís Otávio Zanatta, SERRA, Kátia Piton, SOARES, Fernando Augusto   +6 more
core   +4 more sources

Combining RANK/RANKL and ERBB-2 targeting as a novel strategy in ERBB-2-positive breast carcinomas [PDF]

Breast Cancer Research, 2019
Background ERBB-2 is overexpressed in about 20% of breast cancers (BCs), indicating poor prognosis. The receptor activator of nuclear factor-κB (RANK) pathway is implicated in ERBB-2 (+) BC.
Ilianna Zoi, Michalis V. Karamouzis, Evangelia Xingi, Panagiotis Sarantis, Dimitra Thomaidou, Peter Lembessis, Stamatios Theocharis, Athanasios G. Papavassiliou   +7 more
openalex   +2 more sources

Avaliação do estadiamento, prognóstico e mortalidade do câncer colorretal mediante marcadores tumorais: receptor erbB-2 e caderinas [PDF]

Acta Cirúrgica Brasileira, 2005
PURPOSE: To evaluate the prognostic significance and correlation with staging and degree of cell differentiation of the tumoral expression of the proteins c-erbB-2 and E-cadherin, in patients with colorectal adenocarcinoma.
Artigiani Neto, Ricardo, Goldenberg, Alberto, Jesus, Eliane C., Matos, Delcio, Saad, Sarhan Sydney, Waitzberg, Angela Flávia Logullo   +5 more
core   +4 more sources

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Cell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera, Franco Izzo, María F. Chervo, Agustina Dupont, Violeta A. Chiauzzi, Sofia Bruni, Ezequiel Petrillo, Sharon S. Merin, Mara De Martino, Diego Montero, Claudio Levit, Gabriel Lebersztein, Fabiana Anfuso, Agustina Roldán Deamicis, María F. Mercogliano, Cecilia J. Proietti, Roxana Schillaci, Patricia V. Elizalde, Rosalía I. Cordo Russo   +18 more
doaj   +1 more source

Effect of silencing C-erbB-2 on esophageal carcinoma cell biological behaviors by inhibiting IGF-1 pathway activation

Journal of Cardiothoracic Surgery, 2021
Objective C-erbB-2 has been confirmed to be an oncogene that participates in cell growth, differentiation and division of tumors. We are wondered if its silenced expression can exert an anti-tumor effect. Therefore, this study is conducted to investigate
Zhigao Niu, Wenping Zhang, Jialun Shi, Xiangdong Li, Hanlei Wu   +4 more
doaj   +1 more source

Neuregulin promotes incomplete autophagy of prostate cancer cells that is independent of mTOR pathway inhibition. [PDF]

PLoS ONE, 2012
Growth factors activating the ErbB receptors have been described in prostate tumors. The androgen dependent prostate cancer cell line, LNCaP, expresses the ErbB-1, ErbB-2 and ErbB-3 receptor tyrosine kinases.
Eran Schmukler, Ben Shai, Marcelo Ehrlich, Ronit Pinkas-Kramarski   +3 more
doaj   +1 more source

Identification of nucleolin as new ErbB receptors- interacting protein. [PDF]

PLoS ONE, 2008
BACKGROUND: The ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni, Keren Farin, Ronit Pinkas-Kramarski   +2 more
doaj   +1 more source

The ErbB Signaling Network and Its Potential Role in Endometrial Cancer

Epigenomes, 2023
Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC ...
Georgios Androutsopoulos, Ioanna Styliara, Evgenia Zarogianni, Nadia Lazurko, George Valasoulis, Georgios Michail, Georgios Adonakis   +6 more
doaj   +1 more source

Co-conserved features associated with cis regulation of ErbB tyrosine kinases. [PDF]

PLoS ONE, 2010
BACKGROUND: The epidermal growth factor receptor kinases, or ErbB kinases, belong to a large sub-group of receptor tyrosine kinases (RTKs), which share a conserved catalytic core.
Amar Mirza, Morad Mustafa, Eric Talevich, Natarajan Kannan   +3 more
doaj   +1 more source

Targeting erbB receptors [PDF]

Seminars in Cell & Developmental Biology, 2010
Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Zheng, Cai, Hongtao, Zhang, Jing, Liu, Alan, Berezov, Ramachandran, Murali, Qiang, Wang, Mark I, Greene   +6 more
openaire   +2 more sources