Results 31 to 40 of about 79,537 (233)
Ultrasound microbubble-mediated CRISPR/Cas9 knockout of in HEC-1A cells
Journal of International Medical Research, 2019 Objective Epidermal growth factor receptor 2 (C-erbB-2) is one of the most frequently mutated oncogenes in human tumors. We aimed to evaluate the knockout efficiency of clustered regularly interspaced short palindromic repeat (CRISPR) technology using ...
Junhong Cai +3 more
doaj +1 more source
Diagnostic Pathology, 2010 Background Endometrial carcinoma (EC) is the most common malignancy of the female genital tract. Gene alterations and overexpression of various oncogenes are important in tumor development.
Kandemir Nilufer +6 more
doaj +1 more source
ErbB signaling in brain injury regeneration: Pathway interactions and therapeutic potential
Neural Regeneration ResearchThe ErbB signaling network has recently emerged as a key modulator of central nervous system responses to injury. This review provides a comprehensive overview of ErbB receptors and their ligands, highlighting canonical and non-canonical signaling ...
Patricia Pérez-García +7 more
doaj +1 more source
C-erbB-2 in Serum of Patients with Breast Cancer
The International Journal of Biological Markers, 1999 c-erbB-2 is an oncoprotein which is overexpressed in some breast cancers. Recently it has been established that the extracellular domain of c-erbB-2 is shed into the serum of patients with breast cancer.
L. Harris +3 more
doaj +1 more source
Co-cultures with stem cell-derived human sensory neurons reveal regulators of peripheral myelination [PDF]
, 2017 Effective bidirectional signalling between axons and Schwann cells is essential for both the development and maintenance of peripheral nerve function. We have established conditions by which human induced pluripotent stem cell-derived sensory neurons can
Bennett, David L.H. +5 more
core +2 more sources
JAI (Jurnal Anestesiologi Indonesia), 2009 Latar Belakang: Nyeri akut paska bedah memicu timbulnya gejala klinis patofisiologis, menekan respon imun, sehingga menyebabkan penurunan sistem imun yang akan menghambat penyembuhan luka. Levobupivakain, anestetik lokal durasi panjang efektif mengurangi
Curniawati Trisasi, Marwoto Marwoto
doaj +1 more source
Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. [PDF]
, 2018 BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain ...
Cespedes, Juan Carlos +5 more
core +1 more source
Identification of nucleolin as new ErbB receptors- interacting protein.
PLoS ONE, 2008 BackgroundThe ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni +2 more
doaj +1 more source
Biophysical evidence for intrinsic disorder in the C-terminal tails of the epidermal growth factor receptor (EGFR) and HER3 receptor tyrosine kinases [PDF]
, 2016 The epidermal growth factor receptor (EGFR)/ErbB family of receptor tyrosine kinases includes oncogenes important in the progression of breast and other cancers, and they are targets for many drug development strategies.
Bose, Ron +5 more
core +2 more sources