ErbB‐3 and ErbB‐4 Expression in the Mouse Olfactory Systema
Annals of the New York Academy of Sciences, 1998 ABSTRACT: The interplay between neuregulins and the ErbB receptor family has a pivotal role in the development of several tissues, including the nervous system, and is maintained in the adult olfactory system where extensive plasticity and neurogenesis are retained.
PERROTEAU, Isabelle +4 more
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Interaction between ErbB‐1 and ErbB‐2 transmembrane domains in bilayer membranes [PDF]
FEBS Letters, 2002 The transmembrane domains of ErbB receptor tyrosine kinases are monotopic helical structures proposed to be capable of direct side‐to‐side contact with related receptors. Formation of the resulting homo‐ or hetero‐oligomeric complexes is considered a key step in ligand‐mediated signalling.
Sharpe, Simon +2 more
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Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland
Journal of Mammary Gland Biology and Neoplasia, 1997 ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a kinase. Heregulin serves as a ligand for both receptors.
K L, Carraway +2 more
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, 1989 Eighty-five breast carcinomas from the same number of patients have been assessed immunohistochemically using the antiserum 21N for the presence of the c-erbB-2 protein.
R. A. Walker (7606157) +2 more
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In Transected Nerves, Distal Repair Schwann Cells at the Injury Site Direct and Accelerate Axonal Regrowth. [PDF]
GliaAfter nerve transection in larval zebrafish, proximal and distal Schwann cells have distinct functions at the injury site. Distal repair Schwann cells promote axonal regrowth. Axonal regrowth is normal in mutants with only a few macrophages. ABSTRACT In vertebrate peripheral nerves, damaged axons can regrow after injury, but the outcomes of ...
Lysko DE, Johnson AR, Talbot WS.
europepmc +2 more sources
p53 andc-erbB-2 expression in human prostatic adenocarcinoma cell lines and tumor tissues.
, 1995 p53 andc-erbB-2 expression in human prostatic adenocarcinoma cell lines and tumor ...
ShriHari S. Kadkol (7966844)
core +6 more sources
Targeting erbB receptors [PDF]
Seminars in Cell & Developmental Biology, 2010 Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Zheng, Cai +6 more
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c-erbB-2 expression in benign and malignant breast disease. [PDF]
, 1988 An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies.
Gusterson, BA +17 more
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Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]
, 2002 Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S. +5 more
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Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine +5 more
core +1 more source