Anti-ErbB-2 monoclonal antibodies and ErbB-2-directed vaccines
Cancer Immunology, Immunotherapy, 2002 The tumour antigen ErbB-2 belongs to the epidermal growth factor receptor family. Numerous studies have shown that ErbB-2 is overexpressed in many cancers and it is prognostically important in a subset of malignancies. It is well recognised that this receptor has many characteristics that make it an excellent target for tumour-specific immunotherapy ...
Yip, Yum L., Ward, Robyn L.
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C-erbB-2 in Serum of Patients with Breast Cancer
The International Journal of Biological Markers, 1999 c-erbB-2 is an oncoprotein which is overexpressed in some breast cancers. Recently it has been established that the extracellular domain of c-erbB-2 is shed into the serum of patients with breast cancer.
L. Harris +3 more
doaj +2 more sources
Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland
Journal of Mammary Gland Biology and Neoplasia, 1997 ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a kinase. Heregulin serves as a ligand for both receptors.
K L, Carraway +2 more
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Targeting erbB receptors [PDF]
Seminars in Cell & Developmental Biology, 2010 Our work is concerned with the origins and therapy of human cancers. Members of the epidermal growth factor receptor (EGFR) family of tyrosine kinases, also known as erbB or HER receptors, are over expressed and/or activated in many types of human tumors and represent important therapeutic targets in cancer therapy.
Zheng, Cai +6 more
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Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]
, 2002 Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S. +5 more
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p53 andc-erbB-2 expression in human prostatic adenocarcinoma cell lines and tumor tissues.
, 1995 p53 andc-erbB-2 expression in human prostatic adenocarcinoma cell lines and tumor ...
ShriHari S. Kadkol (7966844)
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Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine +5 more
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L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]
, 2012 During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Carmen Grijota-Martinez (152374) +38 more
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c-erbB-2 expression in benign and malignant breast disease. [PDF]
, 1988 An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies.
Gusterson, BA +17 more
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A new model for ductal carcinoma in situ suggests strategies for treatment [PDF]
, 2002 Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor ...
Gullick, William J.
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