Results 31 to 40 of about 95,906 (268)

Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer [PDF]

, 1999
Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown.
Bezold, G., Dieterle, C., Greulich, K. M., Krähn, Gertraud, Peter, R. U., Wolff, H.   +5 more
core   +1 more source

Endocytosis and intracellular trafficking of ErbBs [PDF]

Experimental Cell Research, 2009
This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family. Growth factor binding to EGFR accelerates its internalization through clathrin-coated pits which is followed by the efficient lysosomal targeting of internalized receptors and results
Alexander, Sorkin, Lai Kuan, Goh
openaire   +3 more sources

The Role of ErbB Receptors in Infection [PDF]

Trends in Microbiology, 2017
Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Jemima Ho, David L. Moyes, Mahvash Tavassoli, Julian R. Naglik   +3 more
openaire   +5 more sources

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors. [PDF]

, 2016
Aberrant Hedgehog (Hh)/glioma-associated oncogene (GLI) signaling has been implicated in cancer progression. Here, we analyzed GLI1, Sonic Hedgehog (Shh) and NF-κB expression in 51 breast cancer (ductal carcinoma) tissues using immunohistochemistry ...
Bei, R., Benvenuto, M, Bonanno, E, Cucchi, Danilo, DE SMAELE, Enrico, DI STEFANO, Enrica, Fantini, M, Frajese, Gv, Gulino, Alberto, Masuelli, Laura, Mattera, Rosanna, Modesti, A, Orlandi, A, Screpanti, Isabella   +13 more
core   +1 more source

Correlation of c-erbB-2, EGF and EGFR expression with postoperative survival of patients with advanced carcinoma of the stomach.

Folia Histochemica et Cytobiologica, 2010
The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz, Jolanta Czyzewska, Andrzej Kemona   +2 more
doaj   +1 more source

Long-term response to second-line afatinib treatment for advanced squamous cell carcinoma non-small cell lung cancer: a rare case report

Journal of International Medical Research, 2020
The ErbB family is composed of four cell membrane receptors: ErbB-1 (epidermal growth factor receptor or human epidermal growth factor receptor [HER]1), ErbB-2 (HER2), ErbB-3 (HER3), and ErbB-4 (HER4).
Mengyao Sun, Ye Guo, Xu Wang, Chao Sun, Jiangbo Shao, Yinghui Xu, Shi Qiu, Kewei Ma   +7 more
doaj   +1 more source

Immunohistochemical evaluation of human epidermal growth factor receptor 2 and estrogen and progesterone receptors in breast carcinoma in Jordan [PDF]

, 2005
INTRODUCTION: Although breast carcinoma (BC) is the most common malignancy affecting Jordanian females and the affected population in Jordan is younger than that in the West, no information is available on its biological characteristics. Our aims in this
AA Abalkhail, AM Ruder, B Zafrani, CR De Potter, CW Elston, D Varshney, DC Allred, DH Choi, DJ Slamon, DJ Slamon, DJ Slamon, E May, Early Breast Cancer Trialists' Collaborative Group, ER Hoff, F Revillion, G Abadjian, G Arpino, G Pauletti, G Pauletti, GN Hortobagyi, HB Muss, J Ashba, J Yang, JA Ligibel, JM Esteban, Jordan Cancer Registry, Ministry of Health, JS Huston, JS Ross, K McKeage, LC Hartmann, LJ Layfield, LK Shawver, M Ferno, M Stierer, MF Kamal, Mohammad Al Hamad, Nidal M Almasri, O Stal, PL Porter, RH Mohammed, S Chariyalertsak, S Eppenberger-Castori, S Paik, S Taucher, SI Rosenthal, SS Amr, T el-A Helal, T Rajkumar, U Berger, W Hanna, WF Anderson, YF Dajani   +51 more
core   +2 more sources

p38MAPK Induces Cell Surface α4 Integrin Downregulation to Facilitate erbB-2-Mediated Invasion

Neoplasia: An International Journal for Oncology Research, 2003
We have previously shown that human breast cancer cells that overexpress erbB-2 are growth factorindependent. In order to test the contribution of erbB2 to this and other transformed phenotypes without the genetic instability of cancer cells, erbB-2 was ...
Kathleen M. Woods Ignatoski, Navdeep K. Grewal, Sonja Markwart, Donna L. Livant, Stephen P. Ethier   +4 more
doaj   +1 more source

EGFR Signaling in Lung Fibrosis

Cells, 2022
In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes.
Fabian Schramm, Liliana Schaefer, Malgorzata Wygrecka   +2 more
doaj   +1 more source

Neuregulin-1 attenuates experimental cerebral malaria (ECM) pathogenesis by regulating ErbB4/AKT/STAT3 signaling. [PDF]

, 2018
BACKGROUND:Human cerebral malaria (HCM) is a severe form of malaria characterized by sequestration of infected erythrocytes (IRBCs) in brain microvessels, increased levels of circulating free heme and pro-inflammatory cytokines and chemokines, brain ...
Cespedes, Juan Carlos, Ford, Byron, Liu, Mingli, Solomon, Wesley, Stiles, Jonathan K, Wilson, Nana O   +5 more
core   +1 more source