Results 71 to 80 of about 34,393 (185)

Microarray Gene Expression Analysis of Lesional Skin in Canine Vesicular Cutaneous Lupus Erythematosus (VCLE)

Veterinary Dermatology, Volume 37, Issue 4, Page 478-487, August 2026.
Background: Vesicular cutaneous lupus erythematosus (VCLE) is a rare autoimmune disease in dogs and is considered the canine counterpart of human subacute cutaneous lupus erythematosus (SCLE). However, the molecular mechanisms underlying VCLE remain incompletely defined.
Treasa Clifford, Lauren W. Stranahan, Dominique J. Wiener, M. Kelly Keating, Renato Leon, Frane Banovic   +5 more
wiley   +1 more source

Overexpression of CD44 accompanies acquired tamoxifen resistance in MCF7 cells and augments their sensitivity to the stromal factors, heregulin and hyaluronan

BMC Cancer, 2012
Background Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases.
Hiscox Stephen, Baruha Bedanta, Smith Chris, Bellerby Rebecca, Goddard Lindy, Jordan Nicola, Poghosyan Zaruhi, Nicholson Robert I, Barrett-Lee Peter, Gee Julia   +9 more
doaj   +1 more source

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, Volume 32, Issue 27, 17 July 2026.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, Volume 20, Issue 7, Page 1857-1876, July 2026.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Dysregulation of Neuregulin-1/ErbB signaling in the hippocampus of rats after administration of doxorubicin

Drug Design, Development and Therapy, 2018
Dehua Liao,1,2 Yujin Guo,3 Daxiong Xiang,2 Ruili Dang,3 Pengfei Xu,3 Hualin Cai,2 Lizhi Cao,1 Pei Jiang3 1Department of Pharmacy, Hunan Cancer Hospital, 2Department of Pharmacy, Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital,
Liao D, Guo Y, Xiang D, Dang R, Xu P, Cai H, Cao L, Jiang P   +7 more
doaj  

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science, Volume 13, Issue 37, 3 July 2026.
In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
wiley   +1 more source

The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.

PLoS ONE, 2017
During development, a multi-potent group of cells known as the cranial neural crest (CNC) migrate to form craniofacial structures. Proper migration of these cells requires proteolysis of cell adhesion molecules, such as cadherins.
Ketan Mathavan, Vikram Khedgikar, Vanessa Bartolo, Dominique Alfandari   +3 more
doaj   +1 more source

Impaired Neurosphere Formation as a Functional Readout of Aberrant EGFR Signaling Kinetics in Olfactory Neural Progenitors From Patients With Schizophrenia

Cell Biology International, Volume 50, Issue 7, July 2026.
ABSTRACT The Epidermal Growth Factor Receptor (EGFR) is a key regulator of neurodevelopment, controlling the proliferation, differentiation, and self‐renewal of neural stem and progenitor cells. Dysregulated EGFR signaling has been implicated in schizophrenia, a neurodevelopmental disorder associated with abnormal cortical maturation.
Tommaso Toffanin, Mario Angelo Pagano, Carlo Idotta, Mauro Salvi, Valentina Bosello‐Travain, Maria Lina Massimino, Roberto Saetti, Marina Silvestrini, Leonardo Meneghetti, Stefano Piazza, Maria Giulia Nanni, Rosangela Caruso, Maria Ferrara, Chiara Montemitro, Luigi Zerbinati, Martino Belvederi Murri, Luigi Grassi, Anna Maria Brunati   +17 more
wiley   +1 more source

Structure-function analysis of nucleolin and ErbB receptors interactions.

PLoS ONE, 2009
BackgroundThe ErbB receptor tyrosine kinases and nucleolin are major contributors to malignant transformation. Recently we have found that cell-surface ErbB receptors interact with nucleolin via their cytoplasmic tail.
Keren Farin, Ayelet Di Segni, Adam Mor, Ronit Pinkas-Kramarski   +3 more
doaj   +1 more source

RANKL Signaling and ErbB Receptors in Breast Carcinogenesis

Trends in Molecular Medicine, 2016
ErbB family members, ErbB1/EGFR/HER-1, ErbB2/HER-2, ErbB3/HER-3 and ErbB4/HER-4, have been implicated in breast cancer (BC) tumorigenicity. Recently, crucial roles for RANK/RANKL signaling in addition to key downstream factor NF-κB have been demonstrated in mammary tumorigenesis.
Zoi, I., Karamouzis, M.V., Adamopoulos, C., Papavassiliou, A.G.   +3 more
openaire   +3 more sources