Results 81 to 90 of about 34,393 (185)
Quantitation of Phosphorylation Preferences of EGFR Tyrosines in Response to HB‐EGF and EGF
Chemistry–Methods, Volume 6, Issue 7, July 2026.The study explores the utility of osmotically‐derived plasma membrane vesicles in quantifying the phosphorylation preferences of the EGFR ligand HB‐EGF. It documents improvements in phosphorylation detection and in ligand bias calculations, thus expanding the research toolkit for cell signaling studies.
Ece Özdemir +2 more
wiley +1 more source
Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib
Experimental Hematology & Oncology, 2018 Background Lapatinib is a tyrosine kinase inhibitor that blocks the HER2 receptor and is typically used in the setting of metastatic breast cancer. Both ERBB2 (HER2) and ERBB3 (HER3) belong to the same family of receptor tyrosine kinases. Dimerization of
John D. Strickley +5 more
doaj +1 more source
CCT7 Expression Affects the Prognosis of Lung Adenocarcinoma
Cancer Reports, Volume 9, Issue 7, July 2026.ABSTRACT Background CCT7 is a chaperonin containing tailless complex polypeptide 1 subunit. The study focused on investigating its prognostic significance for lung adenocarcinoma (LUAD). Methods CCT7 expression in LUAD and matched non‐carcinoma lung samples was examined via TCGA database. Besides, we utilized the GEO database and RT‐qPCR for validating
Yue Li +8 more
wiley +1 more source
Metronomic Chemotherapy in Ovarian Cancer: Current Scenario and AI‐Integrated Future Strategies
Cancer Reports, Volume 9, Issue 7, July 2026.ABSTRACT Background Ovarian cancer (OC) is a globally prevalent malignancy associated with a high mortality rate and marked biological heterogeneity, with most cases arising from epithelial cells and presenting as serous, endometrioid, or clear cell subtypes.
Ravi Chauhan +11 more
wiley +1 more source
Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]
Front Oncol, 2023 Breitenecker K +10 more
europepmc +1 more source
Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs
Journal of Clinical Laboratory Analysis, Volume 40, Issue 13, July 2026.Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo +5 more
wiley +1 more source
The International Journal of Biological Markers, 2003 Background Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis.
I. García +5 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2010 The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz +2 more
doaj +1 more source
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]
J Mammary Gland Biol Neoplasia, 2023 Morato A, Accornero P, Hovey RC.
europepmc +1 more source
MedComm, Volume 7, Issue 7, July 2026.This review illustrates the key mechanisms of osimertinib resistance in EGFR‑mutant NSCLC, including EGFR‑dependent mutations, bypass pathway activation, and SMARCA4‑mediated epigenetic regulation. We also summarize emerging targeted therapies and future perspectives to overcome EGFR‑TKI resistance.
Junfeng Guo, Qiuyuan Wen, Songqing Fan
wiley +1 more source