Results 231 to 240 of about 38,315 (266)
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ErbB receptors and the development of the nervous system
Experimental Cell Research, 2009Tyrosine kinase receptors and their ligands allow communication between cells in the developing and adult organism. An extensive line of research has revealed that 'neuregulins', a family of EGF-like factors that signal via ErbB receptors, are used frequently for cell communication during nervous system development, and control a spectacular spectrum ...
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ERBB receptors and cancer: the complexity of targeted inhibitors
Nature Reviews Cancer, 2005ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression.
Nancy E. Hynes, Heidi Lane
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2015
In metazoa, inductive cell-to-cell interactions play crucial roles, both in embryonic development and in homeostasis. Many such interactions are mediated by RTKs and their soluble or surface-bound ligand growth factors. Type 1 RTKs, also called the ERBB or HER family, comprises four proteins, which bind growth factors of the EGF and neuregulin families.
Gur Pines, Yosef Yarden, Fresia Pareja
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In metazoa, inductive cell-to-cell interactions play crucial roles, both in embryonic development and in homeostasis. Many such interactions are mediated by RTKs and their soluble or surface-bound ligand growth factors. Type 1 RTKs, also called the ERBB or HER family, comprises four proteins, which bind growth factors of the EGF and neuregulin families.
Gur Pines, Yosef Yarden, Fresia Pareja
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The status and role of ErbB receptors in human cancer
Experimental and Molecular Pathology, 2008Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands,
Marian Hajduch +4 more
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Localization and modulation of ErbB receptor tyrosine kinases
Current Opinion in Cell Biology, 2001The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling.
Colleen A Sweeney +3 more
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The ErbB receptor family: a therapeutic target for cancer
Trends in Molecular Medicine, 2002This article reviews the current state of efforts targeting the ErbB family of tyrosine kinase receptors in cancer therapy. In particular, preliminary results will be discussed of studies of the first generation of therapeutics to enter clinical evaluation in malignant diseases.
Eric K. Rowinsky, Johann S. De Bono
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Trafficking of the ErbB receptors and its influence on signaling
Experimental Cell Research, 2003Although members of the ErbB receptor family are found predominantly at the cell surface, these receptors undergo constant cycling between the plasma membrane and the endosomal compartment. In the absence of an activating ligand, these receptors are slowly internalized (t(1/2) approximately 30 min) but are quickly recycled. The constitutive degradation
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Expression of erbB receptors mRNA in thyroid tissues
Biochimica et Biophysica Acta (BBA) - General Subjects, 2004ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors. We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan.
Kazuhiro Nishii +8 more
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Evolutionary Analysis of the ErbB Receptor and Ligand Families
Journal of Molecular Evolution, 2000We have compared all available deduced protein sequences of the ErbB family of receptors and their ligands. Analysis of the aligned sequences of the receptors indicates that there are some differences in the receptors that are specific to invertebrates.
James V. Staros, Richard A. Stein
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Signal transduction and oncogenesis by ErbB/HER receptors
International Journal of Radiation Oncology*Biology*Physics, 2004Growth factors enable cells to escape irradiation-induced death (apoptosis). One important family of growth factors share an epidermal growth factor motif, and all bind to ErbB transmembrane receptors. In response to growth factor ligands, ErbB receptor tyrosine kinases induce a variety of cellular responses, including proliferation, differentiation ...
Mina D. Marmor +2 more
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