Results 251 to 260 of about 2,336,646 (291)

Hydroxytyrosol Reprograms the Tumor Microenvironment in 3D Melanoma Models by Suppressing ERBB Family and Kinase Pathways. [PDF]

Int J Mol Sci
Tovar-Parra D, Mangion MZ.
europepmc   +1 more source

NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB-STAT3 signalling in a non-m5C manner. [PDF]

Clin Transl Med
Hu Y, Chen C, Lin K, Tong X, Huang T, Qiu T, Chen X, Xu J, Xie W, Sun X, Feng S, Lu M, Zhao Z, Chen X, Xue X, Shen X.   +15 more
europepmc   +1 more source

Potential role of epidermal growth factor receptors (EGFR) signaling in the pathogenesis and management of hepatocellular carcinoma. [PDF]

Bioimpacts
Al-Awadhi SSA, Patil P, Shetty P, Shetty PK, Shetty RA, Shetty VV.   +5 more
europepmc   +1 more source

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ErbB Receptors and Cancer.

Methods in molecular biology, 2017
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
Zhixiang Wang
semanticscholar   +4 more sources

ErbB receptors and signaling pathways in cancer.

Current Opinion in Cell Biology, 2009
The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer. Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many epithelial tumors, and clinical studies suggest that they play roles in cancer development and progression.
N. Hynes, Gwen Macdonald
semanticscholar   +3 more sources

The ErbB receptors and their role in cancer progression.

Experimental Cell Research, 2003
The involvement of the ErbB receptor tyrosine kinases in human cancer, as well as their essential role in a variety of physiological events during normal development, have motivated the interest in this receptor family. Approaches taken to block the activity of ErbB receptors in cancer cells have not only proven that they drive in vitro tumor cell ...
Thomas Holbro, G. Civenni, N. Hynes
semanticscholar   +4 more sources

The ErbB receptors and their ligands in cancer: an overview.

Current Drug Targets, 2005
This review article provides an overview on the most recent advances on the role of ErbB receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in cancer pathogenesis and progression. The ErbB tyrosine kinases and the EGF-like peptides form a complex system. In fact, the interactions occurring between receptors and ligands
N. Normanno, C. Bianco, L. Strizzi, M. Mancino, M. Maiello, A. Luca, F. Caponigro, D. Salomon   +7 more
semanticscholar   +4 more sources

ErbB receptors: new insights on mechanisms and biology.

Trends in Cell Biology, 2006
The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors.
B. Linggi, G. Carpenter
semanticscholar   +3 more sources

The EGF/ErbB Receptor Family and Apoptosis

Growth Factors, 2002
The ErbB receptor family can activate a multitude of cell signaling pathways that involve many aspects of cellular function. The four members of the ErbB receptor family interact with diverse ligands and substrates, as well as with each other through cell surface heterodimerization.
Nita J. Maihle, Andrew J. Danielsen
openaire   +2 more sources