Results 41 to 50 of about 38,315 (266)

Direct imaging of lateral movements of AMPA receptors inside synapses [PDF]

EMBO J 22, 18 (15/09/2003) 4656-65, 2007
Trafficking of AMPA receptors in and out of synapses is crucial for synaptic plasticity. Previous studies have focused on the role of endo/exocytosis processes or that of lateral diffusion of extra-synaptic receptors. We have now directly imaged AMPAR movements inside and outside synapses of live neurons using single-molecule fluorescence microscopy ...
arxiv   +1 more source

Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis

BMC Evolutionary Biology, 2006
Background In the time since we presented the first molecular evolutionary study of the ErbB family of receptors and the EGF family of ligands, there has been a dramatic increase in genomic sequences available. We have utilized this greatly expanded data
Staros James V, Stein Richard A
doaj   +1 more source

Induction of ErbB-3 expression by alpha6beta4 integrin contributes to tamoxifen resistance in ERbeta1-negative breast carcinomas.

PLoS ONE, 2008
BackgroundTamoxifen is still the most widely used drug in hormone therapy for the treatment of breast cancer. Its benefits in adjuvant treatment are well documented in controlled and randomized clinical studies, which have demonstrated an increase in ...
Valentina Folgiero, Paolo Avetrani, Giulia Bon, Selene E Di Carlo, Alessandra Fabi, Cecilia Nisticò, Patrizia Vici, Elisa Melucci, Simonetta Buglioni, Letizia Perracchio, Isabella Sperduti, Laura Rosanò, Ada Sacchi, Marcella Mottolese, Rita Falcioni   +14 more
doaj   +1 more source

Towards Scalable Modeling of Biology in Event-B [PDF]

arXiv, 2021
Biology offers many examples of large-scale, complex, concurrent systems: many processes take place in parallel, compete on resources and influence each other's behavior. The scalable modeling of biological systems continues to be a very active field of research.
arxiv  

NSUN2 promotes colorectal cancer progression and increases lapatinib sensitivity by enhancing CUL4B/ErbB-STAT3 signalling in a non-m5C manner. [PDF]

Clin Transl Med
NSUN2 is upregulated in CRC and associated with poor prognosis of CRC patients. NSUN2 promotes CRC malignancy independently of its m5C‐enzymatic activity, a mechanism that has not been previously reported. The non‐m5C carcinogenic roles of NSUN2 may be mediated through interactions with CUL4B, thereby activating the ErbB‐STAT3 signalling pathway. NSUN2‐
Hu Y, Chen C, Lin K, Tong X, Huang T, Qiu T, Chen X, Xu J, Xie W, Sun X, Feng S, Lu M, Zhao Z, Chen X, Xue X, Shen X.   +15 more
europepmc   +2 more sources

RETRACTED: Cytohesins Are Cytoplasmic ErbB Receptor Activators

Cell, 2010
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors.
Bill, A., Schmitz, A., Albertoni, B., Song, J., Heukamp, L., Walrafen, D., Thorwirth, F., Verveer, P., Zimmer, S., Meffert, L., Schreiber, A., Chatterjee, S., Thomas, R., Ullrich, R., Lang, T., Famulok, M.   +15 more
openaire   +4 more sources

Uniting the neurodevelopmental and immunological hypotheses: Neuregulin 1 receptor ErbB and Toll-like receptor activation in first-episode schizophrenia

Scientific Reports, 2017
Current pathophysiological models of schizophrenia focus on neurodevelopmental and immunological mechanisms. We investigated a molecular pathway traditionally linked to the neurodevelopmental hypothesis (neuregulin 1 - ErbB), and pathogen-associated ...
Szabolcs Kéri, Csilla Szabó, Oguz Kelemen   +2 more
doaj   +1 more source

Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer

Cell Death and Disease, 2022
Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or gene amplification of receptor tyrosine kinase ErbB-2/HER2.
Santiago Madera, Franco Izzo, María F. Chervo, Agustina Dupont, Violeta A. Chiauzzi, Sofia Bruni, Ezequiel Petrillo, Sharon S. Merin, Mara De Martino, Diego Montero, Claudio Levit, Gabriel Lebersztein, Fabiana Anfuso, Agustina Roldán Deamicis, María F. Mercogliano, Cecilia J. Proietti, Roxana Schillaci, Patricia V. Elizalde, Rosalía I. Cordo Russo   +18 more
doaj   +1 more source

Large number of receptors may reduce cellular response time variation [PDF]

Physical biology 10 (3), 035008, 2013, 2012
Cells often have tens of thousands of receptors, even though only a few activated receptors can trigger full cellular responses. Reasons for the overabundance of receptors remain unclear. We suggest that, in certain conditions, the large number of receptors results in a competition among receptors to be the first to activate the cell.
arxiv   +1 more source

Uncovering the dynamic effects of DEX treatment on lung cancer by integrating bioinformatic inference and multiscale modeling of scRNA-seq and proteomics data [PDF]

arXiv, 2022
Motivation: Lung cancer is one of the leading causes for cancer-related death, with a five-year survival rate of 18%. It is a priority for us to understand the underlying mechanisms that affect the implementation and effectiveness of lung cancer therapeutics.
arxiv