Results 41 to 50 of about 2,320,040 (329)
The ErbB receptor tyrosine family as signal integrators. [PDF]
Endocrine-related cancer, 2001 ErbB receptor tyrosine kinases (RTKs) and their ligands have important roles in normal development and in human cancer. Among the ErbB receptors only ErbB2 has no direct ligand; however, ErbB2 acts as a co-receptor for the other family members, promoting high affinity ligand binding and enhancement of ligand-induced biological responses.
Nancy E. Hynes +3 more
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Frontiers in Molecular Neuroscience, 2018 Increasing evidence demonstrates that the neurotrophic factor Neuregulin 1 (NRG1) and its receptors, ErbB tyrosine kinases, modulate midbrain dopamine (DA) transmission.
Ada Ledonne +2 more
doaj +1 more source
Systems analysis of drug-induced receptor tyrosine kinase reprogramming following targeted mono- and combination anti-cancer therapy [PDF]
, 2014 The receptor tyrosine kinases (RTKs) are key drivers of cancer progression and targets for drug therapy. A major challenge in anti-RTK treatment is the dependence of drug effectiveness on co-expression of multiple RTKs which defines resistance to single ...
Bown, James L. +8 more
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ErbB Receptors and ErbB Targeted Therapies in Endometrial Cancer
Journal of Cancer Therapy, 2014 The Epidermal Growth Factor system is present in human organs and plays an important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development. It has four receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands.
Androutsopoulos Georgios +3 more
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EGFR Signaling in Lung Fibrosis
Cells, 2022 In this review article, we will first provide a brief overview of the ErbB receptor–ligand system and its importance in developmental and physiological processes.
Fabian Schramm +2 more
doaj +1 more source
Identification of LDH-A as a therapeutic target for cancer cell killing via (i) p53/NAD(H)-dependent and (ii) p53 independent pathways [PDF]
, 2014 Most cancer cells use aerobic glycolysis to fuel their growth. The enzyme lactate dehydrogenase-A (LDH-A) is key to cancer’s glycolytic phenotype, catalysing the regeneration of nicotinamide adenine dinucleotide (NAD þ ) from reduced nicotinamide adenine
Allison, Simon J. +6 more
core +1 more source
Phosphotyrosine interactome of the ErbB‐receptor kinase family [PDF]
Molecular Systems Biology, 2005 Interactions between short modified peptide motifs and modular protein domains are central events in cell signal-transduction. We determined interaction partners to all cytosolic tyrosine residues of the four members of the ErbB-receptor family in an unbiased fashion by quantitative proteomics using pull-down experiments with pairs of phosphorylated ...
Schulze, W. X., Deng, L., Mann, Matthias
openaire +4 more sources
The Dumb ErbB Receptor Helps Healing [PDF]
Journal of Investigative Dermatology, 2007 ErbB3 receptor is a member of the epidermal growth factor (EGF) receptor (ErbB1) family. Okwueze et al. have transfected this receptor in a pig model of wounds and demonstrate that it accelerates the resurfacing of the wounds when combined with epiregulin or heparin-binding EGF. Currently, only hypotheses can be proposed to explain the observations.
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The interactome of human EGF/ErbB receptors [PDF]
Molecular Systems Biology, 2006 Mol Syst Biol. 2: 2006.0006 When you search PubMed for ‘EGF receptor’ (EGFR), the database returns more than 5000 hits. This is not entirely surprising given the receptor's eminent role in cancer biology. However, it is truly surprising that two recent papers published by the groups of Gavin MacBeath and Matthias Mann add a whole new dimension to the ...
Peter Uetz, Igor Stagljar
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Targeting the Calmodulin-Regulated ErbB/Grb7 Signaling Axis in Cancer Therapy
Journal of Pharmacy & Pharmaceutical Sciences, 2013 Signal transduction pathways essential for the survival and viability of the cell and that frequently present aberrant expression or function in tumors are attractive targets for pharmacological intervention in human cancers. In this short review we will
Antonio Villalobo +3 more
doaj +1 more source