Results 91 to 100 of about 610,538 (183)

ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]

J Mammary Gland Biol Neoplasia, 2023
Morato A, Accornero P, Hovey RC.
europepmc   +1 more source

ErbB tyrosyne kinase and the two neuregulin families constitute a ligand-receptor network [PDF]

, 1998
The recently isolated second family of neuregulins, NRG2, shares its primary receptors, ErbB-3 and ErbB-4, and induction of mammary cell differentiation with NRG1 isoforms, suggesting functional redundancy of the two growth factor families.
SHELLY M, WANG LM, ANDREWS GC, KUO A, MOYER JD, LYASS L, RATZKIN BJ, ALROY I, BACUS SS, PIERCE JH, LAVI S, SENGER R, EISENTEIN M, PINKAS KRAMASKI R, ALIMANDI, MAURIZIO, GUARINO B.C., YARDEN Y.   +16 more
core   +1 more source

Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]

Mol Biol Res Commun, 2023
Mashayekh-Poul R, Azimzadeh-Irani M, Masoomi-Nomandan SZ.   +2 more
europepmc   +1 more source

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]

Cancers (Basel), 2022
Adediran S, Wang L, Khan MA, Guang W, Fan X, Dan H, Qi J, Jay SM, Carrier F, Hussain A.   +9 more
europepmc   +1 more source

RANKL Signaling and ErbB Receptors in Breast Carcinogenesis

Trends in Molecular Medicine, 2016
ErbB family members, ErbB1/EGFR/HER-1, ErbB2/HER-2, ErbB3/HER-3 and ErbB4/HER-4, have been implicated in breast cancer (BC) tumorigenicity. Recently, crucial roles for RANK/RANKL signaling in addition to key downstream factor NF-κB have been demonstrated in mammary tumorigenesis.
Zoi, I., Karamouzis, M.V., Adamopoulos, C., Papavassiliou, A.G.   +3 more
openaire   +3 more sources

Molecular biology, expression and clinical significance of ErbB receptors in endometrial cancer

, 2014
The epidermal growth factor system (EGF system) is present in human organs and play important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development.
Adonakis Georgios, Androutsopoulos Georgios, Michail Georgios, Decavalas Georgios   +3 more
core   +1 more source

The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease

Biomarker Insights, 2015
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj   +1 more source

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Molecular Systems Biology, 2009
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis.
William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger   +6 more
doaj   +1 more source

ErbB-1 and ErbB-2 acquire distinct signaling properties dependent upon their dimerization partner

, 1998
The different epidermal growth factor (EGF)-related peptides elicit a diverse array of biological responses as the result of their ability to activate distinct subsets of ErbB receptor dimers, leading to the recruitment of different intracellular ...
Graus-Porta, Diana, Gay, Brigitte, Hynes, Nancy E., Beerli, Roger R., Olayioye, Monilola A., Rohrer, Jack, Hynes NE, Olayioye MA, Gay B, Beerli RR, Rohrer J, Graus-Porta D   +11 more
core   +1 more source

ErbB signaling in brain injury regeneration: Pathway interactions and therapeutic potential

Neural Regeneration Research
The ErbB signaling network has recently emerged as a key modulator of central nervous system responses to injury. This review provides a comprehensive overview of ErbB receptors and their ligands, highlighting canonical and non-canonical signaling ...
Patricia Pérez-García, Nora Martínez-Gómez, Sonia Vázquez-de Górgolas, Andrea Chamorro-Francisco, Ricardo Pardillo-Díaz, Pedro Nunez-Abades, Carmen Castro, Livia Carrascal   +7 more
doaj   +1 more source