Results 71 to 80 of about 610,538 (183)
Sistema Neuregulina1/ErbB: importância no controlo da função cardíaca.
Acta Médica Portuguesa, 2011 The family of Neuregulins (NRG), growth factors like epidermal growth factor, is known to induce growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells. This family comprises four members, being NRG1 the most largely studied,
Luisa Lopes-Conceição +8 more
doaj +1 more source
The Role of ErbB Receptors in Endometrial Cancer
, 2012 Endometrial cancer (EC) is the most common malignancy of the female genital tract. Overall, about 2% to 3% of women develop EC during their lifetime [Jemal et al., 2006]. EC is a malignancy that occurs primarily in postmenopausal women. Based on clinical and pathological features, EC is classified into 2 types [Bokhman, 1983]. Type I EC, represents the
Adonakis Georgios +1 more
openaire +2 more sources
Expression and function of ErbB receptors and ligands in the pituitary [PDF]
Endocrine-Related Cancer, 2011 The role of ErbB family in discreet pituitary functions is reviewed. Several ErbB receptor ligands, EGF, TGFα, and heregulin are differentially expressed in normal gonadotroph and lacto-somatotroph lineages, and other elements of the anterior pituitary. ErbB receptors, i.e.
Odelia, Cooper +4 more
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ErbB targeted therapy in endometrial cancer
, 2015 The Epidermal Growth Factor system is present in human organs and play important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development.
Adonakis Georgios +2 more
core +2 more sources
GENERATION OF pFastBacl-HT AND ISOLATION OF ErbB-2, ErbB-3 AND ErbB-4 cDNAs by RT-PCR [PDF]
, 2000 Over-expression of the ErbB receptor tyrosine kinase subfamily has been implicated in various types of human cancers. In the current study, ErbB-2, ErbB-3, and ErbB-4 tyrosine kinase domain cDNAs were isolated by RT-PCR and subcloned into a pFastBac-HT ...
Diekhans, Stacy
core
Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland
, 1997 ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a ...
Carraway, Kermit +2 more
core +1 more source
, 1998 The four receptor tyrosine kinase I receptors, ErbB-1, ErbB-2, ErbB-3, and ErbB-4, which have been implicated in the development of a variety of normal and malignant tissues, are activated through ligand mediated homo- and heterodimerization.
Lunec J +7 more
core +4 more sources
BMC Cancer, 2012 Background Acquired resistance to endocrine therapy in breast cancer is a significant problem with relapse being associated with local and/or regional recurrence and frequent distant metastases.
Hiscox Stephen +9 more
doaj +1 more source
Drug Design, Development and Therapy, 2018 Dehua Liao,1,2 Yujin Guo,3 Daxiong Xiang,2 Ruili Dang,3 Pengfei Xu,3 Hualin Cai,2 Lizhi Cao,1 Pei Jiang3 1Department of Pharmacy, Hunan Cancer Hospital, 2Department of Pharmacy, Institute of Clinical Pharmacy & Pharmacology, Second Xiangya Hospital,
Liao D +7 more
doaj
, 2003 Hypothalamic astroglial erbB tyrosine kinase receptors are required for the timely initiation of mammalian puberty. Ligand-dependent activation of these receptors sets in motion a glia-to-neuron signaling pathway that prompts the secretion of luteinizing
Anda Cornea +5 more
core +1 more source