Results 81 to 90 of about 610,538 (183)

Type 1 growth factor receptor expression in node positive breast cancer: adverse prognostic significance of c-erbB-4

, 2003
BACKGROUND: There is a clear need to define biological markers that will predict the response to treatment in breast cancer, and several recent studies suggest that the expression of type 1 growth factor receptors may prove important in this regard.
Anderson, J.J., Leonard, R.C., Haugk, B., Lodge, A.J., Gullick, William J., Angus, B.   +5 more
core   +4 more sources

The ectodomain of cadherin-11 binds to erbB2 and stimulates Akt phosphorylation to promote cranial neural crest cell migration.

PLoS ONE, 2017
During development, a multi-potent group of cells known as the cranial neural crest (CNC) migrate to form craniofacial structures. Proper migration of these cells requires proteolysis of cell adhesion molecules, such as cadherins.
Ketan Mathavan, Vikram Khedgikar, Vanessa Bartolo, Dominique Alfandari   +3 more
doaj   +1 more source

Neuregulins Signaling via a Glial erbB-2–erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual Development

, 1999
Activation of erbB-1 receptors by glial TGFα has been shown to be a component of the developmental program by which the neuroendocrine brain controls mammalian sexual development.
Anda Cornea, Diane F. Hill, Gregory D. Plowman, Maria E. Costa, Sergio R. Ojeda, Ying J. Ma, Mario N. Lioubin, Kimberly E. Creswick   +7 more
core   +1 more source

ERBB RECEPTORS DIMERIZATION DEFINES BREAST CANCERS SUBTYPES AND CLINICAL OUTCOMES: IMPLICATION FOR CANCER THERAPIES

, 2016
Breast cancers are classified into categories according to specific criteria, such as histopathological type, tumour grade and more recently the gene expression signature.
Adriana Albini, Nicoletta Macrì, Mattia Lauriola, D’Uva Gabriele, Massimiliano Bonafè, Valerio Gelfo, Davide D’Urso   +6 more
core   +1 more source

Structure-function analysis of nucleolin and ErbB receptors interactions.

PLoS ONE, 2009
BackgroundThe ErbB receptor tyrosine kinases and nucleolin are major contributors to malignant transformation. Recently we have found that cell-surface ErbB receptors interact with nucleolin via their cytoplasmic tail.
Keren Farin, Ayelet Di Segni, Adam Mor, Ronit Pinkas-Kramarski   +3 more
doaj   +1 more source

Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib

Experimental Hematology & Oncology, 2018
Background Lapatinib is a tyrosine kinase inhibitor that blocks the HER2 receptor and is typically used in the setting of metastatic breast cancer. Both ERBB2 (HER2) and ERBB3 (HER3) belong to the same family of receptor tyrosine kinases. Dimerization of
John D. Strickley, Aaron C. Spalding, M. Tye Haeberle, Timothy Brown, Don A. Stevens, Jae Jung   +5 more
doaj   +1 more source

Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]

Front Oncol, 2023
Breitenecker K, Hedrich V, Pupp F, Chen D, Řezníčková E, Ortmayr G, Huber H, Weber G, Balcar L, Pinter M, Mikulits W.   +10 more
europepmc   +1 more source

EGF activates ErbB-2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells

, 1999
The epidermal growth factor (EGF)-receptor (EGFR) family includes four homologous transmembrane receptor protein tyrosine kinases, EGFR, ErbB-2, ErbB-3, and ErbB-4.
Rebecca Hoffman, Sibyl Kane, Vera P. Krymskaya, Reynold A. Panettieri, Andrew Eszterhas, Vincenzo Ciocca   +5 more
core   +1 more source

Epidermal Growth Factor Receptor and c-erbB-2 Contents in Unresectable (UICC R1 or R2) Gastric Cancer

The International Journal of Biological Markers, 2003
Background Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis.
I. García, J.M. Del Casar, M.D. Corte, M.T. Allende, J.L. García-Muñiz, F. Vizoso   +5 more
doaj   +1 more source

Correlation of c-erbB-2, EGF and EGFR expression with postoperative survival of patients with advanced carcinoma of the stomach.

Folia Histochemica et Cytobiologica, 2010
The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz, Jolanta Czyzewska, Andrzej Kemona   +2 more
doaj   +1 more source