Results 181 to 190 of about 6,332 (203)
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Archives of Microbiology, 2015
Azole resistance in the pathogenic yeast Candida albicans poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the azole resistance.
Yonghao, Xu +4 more
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Azole resistance in the pathogenic yeast Candida albicans poses significant challenges for its antibiotic treatment. The conformational change of the target enzyme 14 alpha-demethylase (Erg11p) due to ERG11 gene mutations is one of the mechanisms resulting in the azole resistance.
Yonghao, Xu +4 more
openaire +2 more sources
Association of T916C (Y257H) mutation inCandida albicans ERG11with fluconazole resistance
Mycoses, 2012SummaryRepeated and prolonged use of fluconazole in treating candidosis leads to drug resistance. The aim of this study was to confirm the relationship between T916C (Y257H) mutation inCandida albicans ERG11and fluconazole resistance. We replaced one copy ofERG11withERG11containing the T916C mutation inC.
Jie, Zhao, Yonghao, Xu, Chunyang, Li
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Antimicrobial Agents and Chemotherapy, 2022
We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into
João Nobrega de Almeida +4 more
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We analyzed a cohort of Trichosporon asahii strains with different MICs of fluconazole and voriconazole and evaluated the presence of ERG11 mutations. ERG11 mutation conferring an amino acid change was found and its resistance potential was evaluated by cloning into
João Nobrega de Almeida +4 more
openaire +2 more sources
Biochemical and Biophysical Research Communications, 2004
The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans.
S G, Revankar +7 more
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The ergosterol pathway in fungal pathogens is an attractive antimicrobial target because it is unique from the major sterol (cholesterol) producing pathway in humans. Lanosterol 14alpha-demethylase is the target for a major class of antifungals, the azoles. In this study we have isolated the gene for this enzyme from Cryptococcus neoformans.
S G, Revankar +7 more
openaire +2 more sources
Mycopathologia, 2014
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Jingwen, Tan +6 more
exaly +3 more sources
The mechanism of fluconazole resistance in Candida tropicalis is still unclear. Recently, we isolated a fluconazole-resistant strain of C. tropicalis from the blood specimen of a patient with candidemia in China. In vitro antifungal susceptibility of the isolate was determined by using CLSI M27-A3 and E-test methods. The sequence of ERG11 gene was then
Jingwen, Tan +6 more
exaly +3 more sources
[Analysis of ERG11 gene mutation in Candida albicans].
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA, 2007To study the relationship between fluconazole (FCZ)-resistance of Candida albicans and the mutation of ERG11 gene encoding FCZ-targeted enzyme.Three strains of FCZ-susceptible and 10 FCZ-resistent C. albicans were isolated from the urethra, vagina, oropharynx, respiratory tract, prostate secretion and blood samples.
Ying-bin, Wang +4 more
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Upregulation of the ERG11 gene in Candida krusei by azoles.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2012Candida species are the agents of local and systemic opportunistic infections and have become a major cause of morbidity and mortality in the last few decades. Azole resistance in Candida krusei (C. krusei) species appears to be the result of gene alterations in relation to the ergosterol biosynthesis pathway, as well as efflux pumps.
M, Tavakoli +5 more
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2020
Azoles are the most representative group of antifungal agents for the treatment of surface and invasive mycoses caused by members of the genus Candida. The mechanism of action of azoles involves competitive binding to the cytochrome P450 family enzyme lanosterol 14 alpha-demethylase (cyp51A), which catalyzes the biosynthesis of ergosterol (a key ...
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Azoles are the most representative group of antifungal agents for the treatment of surface and invasive mycoses caused by members of the genus Candida. The mechanism of action of azoles involves competitive binding to the cytochrome P450 family enzyme lanosterol 14 alpha-demethylase (cyp51A), which catalyzes the biosynthesis of ergosterol (a key ...
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Variation in the erg11 Gene from Pneumocystis jirovecii.
2010The erg11 gene codes for sterol 14-demethylase (14DM), a key enzyme in sterol biosynthesis and the target for triazole antimycotic drugs. Two sterol composition phenotypes have been described in patients with pneumonia caused by P. jirovecii; one phenotype has a much higher amount of lanosterol derivatives (C31 and C32 sterols) dominated by ...
SCOTT P. KEELY +6 more
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ERG11 mutations and upregulation in clinical itraconazole-resistant isolates of Candida krusei
Canadian Journal of Microbiology, 2016To better understand the association between the ERG11 gene and drug resistance in Candida krusei, C. krusei strains were isolated from patients from January 2010 to May 2013. Susceptibility to 5-fluorocytosine (5-FC), amphotericin B (AMB), voriconazole (VRC), fluconazole (FLC), and itraconazole (ITR) were tested by broth microdilution method ...
Wenli, Feng +5 more
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