Results 61 to 70 of about 974 (83)

Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death. [PDF]

J Transl Med
Singh V, Wagner KT, Williams LG, Ryan JM, Keller KR, Mohnkern JD, Gardner RS, Dang LT, Ziobro JM, Wojcikiewicz RJH, Tucker NR, Auerbach DS.   +11 more
europepmc   +1 more source

Low Proarrhythmic Risk of Imetelstat, a Novel Oligonucleotide Telomerase Inhibitor: A Translational Analysis. [PDF]

Clin Transl Sci
Lennox AL, Sun L, Huang F, Behrs MK, Kleiman R, Xue H, Bhise N, Wan Y, Berry T, Feller F, Morcos PN.   +10 more
europepmc   +1 more source

Molecular insights into the rescue mechanism of an HERG activator against severe LQT2 mutations. [PDF]

J Biomed Sci
Kumawat A, Tavazzani E, Lentini G, Trancuccio A, Kukavica D, Oldani A, Denegri M, Priori SG, Camilloni C.   +8 more
europepmc   +1 more source

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The ERG1 Potassium Channel is Abundant in Cachectic Human Skeletal Muscle

FASEB Journal, 2020
Introduction A heteromultimer of the ERG1a/1b potassium channel is known to contribute to repolarization of the cardiac action potential. A homomultimer of the ERG1a subunit has been detected in the atrophying skeletal muscle of mice experiencing muscle disuse and cancer cachexia and has been shown to contribute
Sandra Zampieri
exaly   +2 more sources

Functional expression of ERG1 potassium channels in rat alveolar macrophages

Journal of Molecular Histology, 2012
Alveolar macrophages (AMs) play a vital role in lung immunity. The recent studies demonstrated that potassium channels were associated with macrophage functions, such as activation, migration and cytokines secretion. However, less is known regarding the expression and function of ERG channels in AMs.
Wu Yousheng, Liu Manling, Wang Yanxia
exaly   +3 more sources

Expression and immunolocalization of ERG1 potassium channels in the rat kidney

Histochemistry and Cell Biology, 2009
Potassium (K(+)) channels participate in K(+) secretion, K(+) recycling, and cell volume regulation and help to maintain the resting potential in mammalian kidneys. Previously, we identified a set of voltage-gated K(+) channels (Kv1) in the inner medullary collecting duct of the rat kidney.
Joyce Trujillo Silva, Bobadilla Norma A, Carolina Salvador   +2 more
exaly   +3 more sources

Expression and coassociation of ERG1, KCNQ1, and KCNE1 potassium channel proteins in horse heart

American Journal of Physiology - Heart and Circulatory Physiology, 2002
In dogs and in humans, potassium channels formed by ether-a-go-go-related gene 1 protein ERG1 (KCNH2) and KCNQ1 α-subunits, in association with KCNE β-subunits, play a role in normal repolarization and may contribute to abnormal repolarization associated with long QT syndrome (LQTS).
Robert F Gilmour, Kathy E Mitchell
exaly   +3 more sources

Ether-à-gogo-related gene (erg1) potassium channels shape the dark response of horizontal cells in the mammalian retina

Pflugers Archiv European Journal of Physiology, 2008
Postsynaptic to photoreceptors, horizontal cells face prolonged exposure to glutamate in the dark. Therefore, efficient hyperpolarizing mechanisms are crucial to keep horizontal cells within an operating range and to reduce glutamate-induced excitotoxicity.
Reto Weiler
exaly   +3 more sources

Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3

Gene Expression Patterns, 2003
Deciphering the expression pattern of K+ channel encoding genes during development can help in the understanding of the establishment of cellular excitability and unravel the molecular mechanisms of neuromuscular diseases. We focused our attention on genes belonging to the erg family, which is deeply involved in the control of neuromuscular ...
Laura Gragnani, Serena Pillozzi, Alessio Masi   +2 more
exaly   +3 more sources

Involvement of the potassium channel ERG1 in cholangiocarcinoma

Digestive and Liver Disease
C Raggi, M Pastore
exaly   +2 more sources