Results 91 to 100 of about 576 (123)
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Inhibition of Prolactin Secretion by Ergolines
Endocrinology, 1974Peptide-containing ergot alkaloids and synthetic ergoline derivatives were administered to reserpine-treated male rats in order to evaluate their prolactin-inhibiting properties. Each compound was administered ip at a standard 50 ¼g/kg dose. The 9,10-dihydrogenated ergots, dihydroergocornine, and dihydroergocryptine were able to inhibit prolactin to ...
J A, Clemens +4 more
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Electrophilic substitution of lithiated ergolines
Tetrahedron Letters, 1988Abstract Substitution of the ergoline derivative terguride 1 in the positions 2, 12 and 13 is effected by reaction of the respective bromo-ergolines with tert .-butyllithium and an electrophile in a regioselective manner.
Gerhard Sauer +2 more
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ChemInform Abstract: Serotonergic Ergoline Derivatives.
ChemInform, 1998AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
S. MANTEGANI +6 more
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Regiocontrolled electrochemical cyanation of ergolines
Tetrahedron Letters, 1983Abstract An electrochemical procedure for the preparation of the 2-cyano ergolines (2) is described.
Karlheinz Seifert +2 more
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1,2-Fused derivatives of ergoline
Collection of Czechoslovak Chemical Communications, 19822-Formylergoline derivatives I and II were condensed with methyl isonitrilacetate in the presence of a base. Depending on the nature of this base, the main products of the reaction were either derivatives of pyrimido[1,6-a]ergoline, III and IV, or derivatives of 2-formylamino-3-oxo-3H-pyrrolo[1,2-a]ergoline, V and VI.
Jan Beneš, Jiří Holubek
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Antihypertensive ergoline derivatives.
Drug design and delivery, 1989Novel ergolines were synthesized and screened in spontaneous hypertensive rats (SHR) with the aim of finding a new class of ergot related antihypertensives. Their prolactin inhibitory effect (measured as nidation inhibition in rats), acute toxicity (LD50) and interference with CNS function (Irwin test) were also evaluated as a measure of selectivity ...
S, Mantegani +6 more
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A Crystallographic Investigation of Ergolines
Structural Chemistry, 2002The X-ray crystal structures of three ergoline derivatives have been completed and are reported herein. These include mesulergine hydrochloride (III), pergolide methanesulfonate (IV), and dihydroergocriptine hydrate (V). These molecules show dopamine agonist activity at the D2 receptor.
Naijue Zhu +3 more
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2-Acylated derivatives of ergoline
Collection of Czechoslovak Chemical Communications, 1982Reactions of ergoline derivatives Ia-VIIa with anhydrides of low-molecular-weight aliphatic acids, catalysed by boron trifluoride etherate, gave 2-acylated derivatives Ib-Id, IIb-IId, IIIb-Vb, or 1,2-diacylated derivatives VIb and VIIb. The compound IIb exhibited a hypotensive effect.
Jan Beneš, Jiří Křepelka
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[Ergoline-induced retroperitoneal fibrosis].
Ugeskrift for laeger, 2006A 69-year-old man presented with anaemia, swelling of the legs and scrotum, weight gain and fatigue. MR scan and laboratory findings initiated a search for cancer, but eventually retroperitoneal fibrosis (RF) was suspected. A medical review revealed that an ergoline-based drug known to be associated with RF had been used for eight years.
Lars, Munksgaard +3 more
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2012
The photoaddition of water to the ergot clavinet alkaloid, lysergene, has been reported by Shough and Taylor. The product of this reaction, 10-hydroxyagroclabine, was found to rearrange in aqueous acid to give the 8-hydroxy derivative setoclavine. A second photoaddition of water than gave the 8,10-dihydroxy derivative, lumisetoclavine.
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The photoaddition of water to the ergot clavinet alkaloid, lysergene, has been reported by Shough and Taylor. The product of this reaction, 10-hydroxyagroclabine, was found to rearrange in aqueous acid to give the 8-hydroxy derivative setoclavine. A second photoaddition of water than gave the 8,10-dihydroxy derivative, lumisetoclavine.
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