Results 91 to 100 of about 2,032 (166)

Conversion of ergolines to hexahydro- and octahydrobenzo[f]quinolines (depyrroloergolines).

Journal of Medicinal Chemistry, 1980
A general method has been developed for removal of the pyrrole ring from the ergolines. Oxidation of various ergolines at the 2,3 double bond gave formamido ketones 10, which afforded the amino ketones 11.
N. Bach, E. Kornfeld, J. Clemens, E. Smalstig   +3 more
semanticscholar   +5 more sources

Ergot alkaloids. New ergolines as selective dopaminergic stimulants.

Journal of Medicinal Chemistry, 1978
A new two-step sequence for the epimerization of methyl dihydrolysergate (5) at C-8 leading to methyl dihydroisolysergate (7) is presented. The latter compound was used as a starting material for the synthesis of various ergolines, of which (5R,8R,10R)-8-
P. Stütz, P. Stadler, J. Vigouret, A. Jaton   +3 more
semanticscholar   +2 more sources

Ergoline derivatives—XIV

Tetrahedron, 1974
Abstract The treatment of methyl lysergate with mercuric acetate in methanol yields, instead of the expected 10 - methoxy - 6 - methyl - ergoline - 8 β - carboxylic acid methyl ester (2), 10 - methoxy - 8,9 - didehydro - 6 - methyl - ergoline - 8 - carboxylic acid methyl ester (3), whose structure is demonstrated.
Luciano Bernardi, Elena Gandini, A. Temperilli   +2 more
openalex   +3 more sources

Ergoline derivatives—IX

Tetrahedron, 1969
Abstract The preparation of the four isomeric methyl 10-methoxydihydrolysergates is reported. The configurations are assigned and the conformation of rings C and D is discussed. A mechanism for the formation of these 10-methoxy derivatives is suggested.
W. Barbieri, Luciano Bernardi, G. Bosisio, A. Temperilli   +3 more
openalex   +4 more sources

Studies on the metabolism of ergoline derivatives

Biochemical Pharmacology, 1972
Abstract Tritium labelled nicergoline is rapidly absorbed from the gut in rat, dog, monkey and man. In the rat radioactivity was present in all tissues examined from 30 min to 12 hr after the administration. In all species tested labelled nicergoline was extensively metabolized in the body and the final products, labelled 1,6-dimethyl-8β ...
F Arcamone, Adrian Glasser, J Grafnetterová, A. Minghetti, V. Nicolella   +4 more
openalex   +4 more sources

Experiences with a new ergoline (CF 25–397) in parkinsonism

Neurology, 1977
Studies on rats with unilateral nigral lesions suggest that a new ergoline, CF 25-397, is a dopaminergic agonist that might improve parkinsonism. CF 25-397 induces less stereotyped behavior than other dopaminergic agents in rats, and might therefore cause less dyskinesia than levodopa in man.
Paul F. Teychenné, R. Pfeiffer, S. M. Bern, Donald B. Calne   +3 more
openalex   +4 more sources

ChemInform Abstract: Electrochemical Oxidation of Ergolines. [PDF]

ChemInform, 1992
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Karlheinz Seifert, Nguyen Minh Phuong, Beverly R. Vincent   +2 more
openaire   +2 more sources

Preparation and Characterization of Ergoline Thiazolidinones and an Ergoline Imidazolidinone

Archiv der Pharmazie, 1986
AbstractThe preparation of the ergoline thiazolidinones 2,3 and the ergoline imidazolidinone 5 is described. The 13C‐ and 15N‐NMR spectra of the 15N‐labelled compounds 15N‐ 2a and 15N‐3a allow the distinction of the two isomers.
Karlheinz Seifert, S. Haertling, Siegfried Johne   +2 more
openaire   +3 more sources

From Ergolines to Indoles: Improved Inhibitors of the Human H3 Receptor for the Treatment of Narcolepsy

ChemMedChem, 2015
Ergolines were recently identified as a novel class of H3 receptor (H3R) inverse agonists. Although their optimization led to drug candidates with encouraging properties for the treatment of narcolepsy, brain penetration remained low.
Y. Auberson, T. Troxler, Xuechun Zhang, Charles R. Yang, D. Feuerbach, Yu‐Chih Liu, B. Lagu, M. Perrone, Lijun Lei, Xiaoxia Shen, Dushan Zhang, Chunxiu Wang, Tie-lin Wang, K. Briner, M. Bock   +14 more
semanticscholar   +1 more source

ChemInform Abstract: Serotonergic Ergoline Derivatives.

ChemInform, 1998
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Carla Caccia, Gabriele Damiani, Enzo Brambilla, Robert A. McArthur, M. G. Fornaretto, Mario Varasi, Sergio Mantegani   +6 more
openaire   +4 more sources