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ERGOVALINE MOVEMENT ACROSS CACO-2 CELLS

In Vitro Cellular and Developmental Biology--Animal, 2005
Ergovaline's role in the direct causation of fescue toxicosis first requires establishment of its dietary absorption. Therefore, ergovaline movement across human intestinal cells was assessed using Caco-2 cells derived from human colon carcinoma. A pre-equilibrated mixture of ergovaline/ergovalinine (60:40 ratio of isomers) was added to the apical ...
Nancy W, Shappell, David J, Smith
openaire   +2 more sources

Ergovaline levels in cultivars of Festuca arundinacea

Animal Feed Science and Technology, 2001
This work was funded by the “Junta de Castilla y Leon “ (CSI3/98). Beatriz R. Vazquez de Aldana was supported by a Research Contract from the Spanish “Ministerio de Ciencia y Tecnologia”.
B.R. Vázquez de Aldana   +3 more
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A gene cluster for ergovaline biosynthesis

NZGA: Research and Practice Series, 2007
Some strains of Epichloë and Neotyphodium endophytes produce the ergot alkaloid ergovaline, which is implicated in livestock toxicoses caused by ingestion of endophyte-infected grasses.
D.J. Fleetwood   +4 more
openaire   +1 more source

Ruminal tryptophan-utilizing bacteria degrade ergovaline from tall fescue seed extract

Journal of Animal Science, 2017
The objectives of this study were to evaluate degradation of ergovaline in a tall fescue [ (Schreb.) Darbysh.] seed extract by rumen microbiota ex vivo and to identify specific bacteria capable of ergovaline degradation in vitro. Rumen cell suspensions were prepared by harvesting rumen fluid from fistulated wether goats ( = 3), straining, and ...
B E, Harlow   +5 more
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Ergovaline binding and activation of D2 dopamine receptors in GH4ZR7 cells

Journal of Animal Science, 1995
Ergovaline inhibition of radioligand binding to the D2 dopamine receptor and ergot alkaloid inhibition of vasoactive intestinal peptide (VIP)-stimulated cyclic AMP production in GH4ZR7 cells, stably transfected with a rat D2 dopamine receptor, were evaluated. Ergovaline inhibition of the binding of the D2-specific radioligand, [3H]YM-09151-2, exhibited
B T, Larson   +6 more
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Evidence that ergovaline acts on serotonin receptors

Life Sciences, 1993
Ergovaline is a potent vasoconstrictor of isolated bovine uterine and umbilical arteries. Contractions to ergovaline were slow to develop and required 120 min or more to reach their maximum effect. Tissues contracted to ergovaline did not relax over a 3 hr period despite repeated changing of the bath fluid with fresh Krebs solution.
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Ergovaline Distribution in Perennial Ryegrass Naturally Infected with Endophyte

1997
Recently there has been renewed interest in the possible impact on animal health and performance and insect resistance of ergovaline in perennial ryegrass (Lolium perenne) naturally infected with Neotyphodium lolii. In an earlier limited study of vegetative plants, ergovaline was found to be concentrated in basal tissues (Davies et al., 1993).
G. A. Lane   +3 more
openaire   +1 more source

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