Results 91 to 100 of about 317,386 (198)

P2X3 receptor involvement in endometriosis pain via ERK signaling pathway

PLOS ONE, 2017
The purinergic receptor P2X ligand-gated ion channel 3 (P2X3) is crucially involved in peripheral nociceptive processes of somatic and visceral pain. Endometriosis pain is considered as a kind of inflammatory and neuropathic pain. However, whether P2X3 is involved in endometriosis pain has not been reported up to date.
Shaojie Ding, Libo Zhu, Yonghong Tian, Tianhong Zhu, Xiufeng Huang, Xinmei Zhang   +5 more
openaire   +4 more sources

Autophagy processes are dependent on EGF receptor signaling [PDF]

, 2018
Autophagy is a not well-understood conserved mechanism activated during nutritional deprivation in order to maintain cellular homeostasis. In the present study, we investigated the correlations between autophagy, apoptosis and the MAPK pathways in ...
Capodifoglio, Sabrina, Caruso, Marika, Conti, Pio, Flati, Vincenzo, Iuliis, Vincenzo De, Lanuti, Paola, Marino, Antonio, Marricareda, Valeria, Martinotti, Stefano, Marynuk, Anna, Talora, Claudio, Toniato, Elena, Ursi, Sebastiano   +12 more
core   +1 more source

A Dual Role of HGF-ERK Signaling in IL6/HGF-induced Hepatocyte ProliferationSummary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Primary hepatocytes are difficult to expand in vitro. Hepatocyte growth factor (HGF) and epidermal growth factor (EGF) have long been used to maintain primary hepatocytes in vitro but with limited growth promotion effect ...
Jingwei Zhang, Shitong Wang, Jiani Yu, Bing Li, Shun Wang, Na Suo, Ren Guo, Xin Xie   +7 more
doaj   +1 more source

Erk Signaling Suppresses Embryonic Stem Cell Self-Renewal to Specify Endoderm

Cell Reports, 2014
Fgf signaling via Erk activation has been associated with both neural induction and the generation of a primed state for the differentiation of embryonic stem cells (ESCs) to all somatic lineages.
William B. Hamilton, Joshua M. Brickman   +1 more
doaj   +1 more source

Dexamethasone-Induced Expression of Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Involves Activation of the Transcription Factors Activator Protein-1 and 3',5'-Cyclic Adenosine 5'-Monophosphate Response Element-Binding Protein and the Generation of Reactive Oxygen Species [PDF]

, 2008
We have recently identified the MAPK phosphatase (MKP)-1 as a novel mediator of the antiinflammatory properties of glucocorticoids (dexamethasone) in the human endothelium. However, nothing is as yet known about the signaling pathways responsible for the
Abraham, Abraham, Angelika M. Vollmar, Bagowski, Bokemeyer, Bokemeyer, Castro-Caldas, Clark, Clark, Dickinson, Fürst, Fürst, Fürst, Hafezi-Moghadam, Iuchi, Karst, Kiemer, Kiemer, Kim, Koukouritaki, Kwak, Lang, Limbourg, Liu, Liu, Long, Pelaia, Qiu, Robert Fürst, Sanchez-Tillo, Schaaf, Simoncini, Song, Stahn, Stefan Zahler, Sun, Zahler   +36 more
core   +1 more source

RETRACTED ARTICLE: Reducing PKCδ inhibits tumor growth through growth hormone by inhibiting PKA/CREB/ERK signaling pathway in pituitary adenoma

Scientific Reports
Patients with growth hormone-secreting pituitary adenoma (GHPA) often fail to exhibit the molecular signatures typically associated with tumorigenesis.
Xi Chen, Jianyao Mao, Liwei Zhou, Weichao Jiang, Zhangyu Li, Yukui Li, Sifang Chen, Guowei Tan, Yuanyuan Xie, Chen Wang, Jinli Sun   +10 more
doaj   +1 more source

Layer specific and general requirements for ERK/MAPK signaling in the developing neocortex

eLife, 2016
Aberrant signaling through the Raf/MEK/ERK (ERK/MAPK) pathway causes pathology in a family of neurodevelopmental disorders known as 'RASopathies' and is implicated in autism pathogenesis.
Lei Xing, Rylan S Larsen, George Reed Bjorklund, Xiaoyan Li, Yaohong Wu, Benjamin D Philpot, William D Snider, Jason M Newbern   +7 more
doaj   +1 more source

Effects of keratin filaments on ERK signaling during Fas-induced death of cervical cancer (HeLa) cells [PDF]

, 2014
Survival of cancer cells is influenced by a variety of factors, including physical elements such as keratin filaments. We know HeLa cells containing or lacking keratin 8/18 intermediate filaments (K+ and K- cells, respectively) are more sensitive to the ...
Berger, Amanda
core   +1 more source

HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes [PDF]

, 2010
Histone deacetylases (HDACs) regulate the acetylation of histones in the control of gene expression. Many non-histone proteins are also targeted for acetylation, including TGF-ß signalling pathway components such as Smad2, Smad3 and Smad7. Our studies in
Andrew D. Rowan, Bain, Cao, Chen, Chen, Cho, Clayton, David A. Young, de Ruijter, Denker, Dennler, Derynck, Dylan R. Edwards, Fecteau, Gary J. Litherland, Ghosh, Glenisson, Glozak, Gottlicher, Gregoretti, Gurvich, Hazzalin, Horowitz, Ian M. Clark, Khan, Kobayashi, Kouzarides, Kuang, Kwak, Le Pabic, Le Pabic, Lee, Leon Pybus, Li, Lien, Litherland, Mahlknecht, Matt J. Barter, Michaelis, Rombouts, Shi, Tim E. Cawston, Togi, Tu, Vannini, Verdin, Wang, Whitmarsh, Wrana, Xu, Yamaguchi, Yoshikawa, Young, Yu, Zhang   +54 more
core   +1 more source

Xbra modulates the activity of linker region phosphorylated Smad1 during Xenopus development

Scientific Reports
The Bmp/Smad1 pathway plays a crucial role in developmental processes and tissue homeostasis. Mitogen-activated protein kinase (Mapk)/Erk mediated phosphorylation of Smad1 in the linker region leads to Smad1 degradation, cytoplasmic retention and ...
Santosh Kumar, Zobia Umair, Vijay Kumar, Ravi Shankar Goutam, Soochul Park, Unjoo Lee, Jaebong Kim   +6 more
doaj   +1 more source