Results 111 to 120 of about 317,386 (198)

TMEFF2 modulates the AKT and ERK signaling pathways.

International journal of biochemistry and molecular biology, 2013
The transmembrane protein with epidermal growth factor (EGF) and two follistatin (FS) motifs 2 (TMEFF2) has a limited tissue distribution with strong expression only in brain and prostate. While TMEFF2 is overexpressed in prostate cancer indicating an oncogenic role, several studies indicate a tumor suppressor role for this protein.
Xiaofei, Chen, Maria J, Ruiz-Echevarría
openaire   +1 more source

Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats

Scientific Reports
Secondary lung injury after SCI is a major cause of patient mortality, with apoptosis playing a key role. This study aimed to explore the impact of treadmill training and miR145-5p on the MAPK/Erk signaling pathway and apoptosis in rats with complete SCI.
Xianbin Wang, Yingxue Fu, Xianglian Yang, Yan Chen, Ni Zeng, Shouxing Hu, Shuai Ouyang, Xiao Pan, Shuang Wu   +8 more
doaj   +1 more source

18β-glycyrrhetinic acid accelerates liver regeneration after partial hepatectomy in mice

Medicine in Drug Discovery
Objective: 18β-Glycyrrhetinic acid (18β-GA), a key bioactive triterpenoid in Glycyrrhiza uralensis Fisch, is recognized for its hepatoprotective effects in liver injury.
Yuan Li, Yanxin Zhang, Guanqun Wan, Shaofei Song, Tingting Zhao, Renjie Cao, Weiwei Zeng, Min Huang, Yiming Jiang   +8 more
doaj   +1 more source

MEK inhibitors: a promising targeted therapy for cardiovascular disease

Frontiers in Cardiovascular Medicine
Cardiovascular disease (CVD) represents the leading cause of mortality and disability all over the world. Identifying new targeted therapeutic approaches has become a priority of biomedical research to improve patient outcomes and quality of life.
Khaled A. K. Mohammed, Khaled A. K. Mohammed, Paolo Madeddu, Elisa Avolio   +3 more
doaj   +1 more source

Role of insulin signaling dysregulation in pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension

Frontiers in Cardiovascular Medicine
BackgroundPulmonary arterial hypertension (PAH) is a severe disease marked by the remodeling of arteries due to the abnormal growth of vascular cells, including pulmonary arterial smooth muscle cells (PASMCs).
Gufeng Gao, Gufeng Gao, Gufeng Gao, Gufeng Gao, Gufeng Gao, Ai Chen, Ai Chen, Ai Chen, Ai Chen, Ai Chen, Yan Yan, Yan Yan, Yan Yan, Yan Yan, Yan Yan, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Mohammad Ismail Hajary Sagor, Weijun Lin, Weijun Lin, Weijun Lin, Weijun Lin, Weijun Lin, Huakan Lin, Huakan Lin, Huakan Lin, Huakan Lin, Huakan Lin, Guili Lian, Guili Lian, Guili Lian, Guili Lian, Guili Lian, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Liangdi Xie, Li Luo, Li Luo, Li Luo, Li Luo, Li Luo   +44 more
doaj   +1 more source

KIF15 promotes bladder cancer proliferation via the MEK-ERK signaling pathway.

Cancer management and research, 2019
Bladder cancer (BC) is the most common cancer of the urinary tract and invariably predicts a poor prognosis. In this study, we found a reliable gene signature and potential biomarker for predicting clinical prognosis.The gene expression profiles were obtained from the GEO database.
Zhao H, Bo Q, Wu Z, Liu Q, Li Y, Zhang N, Guo H, Shi B   +7 more
openaire   +3 more sources

Tumor promoter TPA activates Wnt/β-catenin signaling in a casein kinase 1-dependent manner. [PDF]

, 2018
The tumor promoter 12-O-tetra-decanoylphorbol-13-acetate (TPA) has been defined by its ability to promote tumorigenesis on carcinogen-initiated mouse skin.
Carson, Dennis A, Li, Shiyue, Liu, Shan-Shan, Lu, Desheng, Song, Jiaxing, Su, Zijie, Sun, Qi, Wang, Zhongyuan, Wei, Lei, Xia, Yuqing, Yu, Shubin, Zhao, Liang, Zhou, Liang   +12 more
core  

Variable thresholds for phosphorylation targets of the ERK signaling pathway. [PDF]

Proc Natl Acad Sci U S A
Hayashi K, Sekaran S, Simpson P, Ebmeier CC, Michel CR, Ahn NG.   +5 more
europepmc   +1 more source

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway. [PDF]

Int J Mol Med
Zhu Y, Wang X, Lin J, Wang X, Zheng K, Ren Z, Xiao J, Wang Y.   +7 more
europepmc   +1 more source

Nintedanib Eye Drops Inhibit Alkali Burn-Induced Corneal Neovascularization Via RAP1/MEK/ERK Signaling Pathway. [PDF]

Invest Ophthalmol Vis Sci
Li J, Zhang G, Li J, Liu R, Zhu L, Li J, Li Z.   +6 more
europepmc   +1 more source