Results 101 to 110 of about 317,386 (198)
Galectin-3-mediated glial crosstalk drives oligodendrocyte differentiation and (Re)myelination [PDF]
, 2018 Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a carbohydrate-recognition domain (CRD).
Pasquini, Laura Andrea, Thomas, Laura
core +1 more source
MoleculesThe journal retracts the article titled “A Ferulic Acid Derivative FXS-3 Inhibits Proliferation and Metastasis of Human Lung Cancer A549 Cells via Positive JNK Signaling Pathway and Negative ERK/p38, AKT/mTOR and MEK/ERK Signaling Pathways” [...]
Shi-Jun Yue +11 more
doaj +1 more source
Affinity and dose of TCR engagement yield proportional enhancer and gene activity in CD4+ T cells. [PDF]
, 2016 Affinity and dose of T cell receptor (TCR) interaction with antigens govern the magnitude of CD4+ T cell responses, but questions remain regarding the quantitative translation of TCR engagement into downstream signals.
Allison, Karmel A +7 more
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Cucurbitacin E inhibits the Yes‑associated protein signaling pathway and suppresses brain metastasis of human non‑small cell lung cancer in a murine model. [PDF]
, 2019 Human non‑small cell lung cancer (NSCLC) is associated with an extremely poor prognosis especially for the 40% of patients who develop brain metastasis, and few treatment strategies exist.
Hsu, Ping-Chih +9 more
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Current perspectives of the signaling pathways directing neural crest induction. [PDF]
, 2012 The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body.
García-Castro, Martín I +1 more
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Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]
, 2003 Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A +4 more
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ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling
American Journal of Physiology-Cell Physiology, 2011 The mammalian target of rapamycin (mTOR) is a protein kinase that, when present in a complex referred to as mTOR complex 1 (mTORC1), acts as an important regulator of growth and metabolism. The activity of the complex is regulated through multiple upstream signaling pathways, including those involving Akt and the extracellular-regulated kinase (ERK ...
Jeremiah N, Winter +2 more
openaire +3 more sources
eLifeBRAFV600E mutation is a driver mutation in the serrated pathway to colorectal cancers. BRAFV600E drives tumorigenesis through constitutive downstream extracellular signal-regulated kinase (ERK) activation, but high-intensity ERK activation can also ...
Chenxi Gao +9 more
doaj +1 more source
PLoS ONE, 2014 Cellular signaling pathways involving mTOR, PI3K and ERK have dominated recent studies of breast cancer biology, and inhibitors of these pathways have formed a focus of numerous clinical trials.
Euphemia Y Leung +5 more
doaj +1 more source
The ASD Living Biology: from cell proliferation to clinical phenotype. [PDF]
, 2019 Autism spectrum disorder (ASD) has captured the attention of scientists, clinicians and the lay public because of its uncertain origins and striking and unexplained clinical heterogeneity.
Courchesne, Eric +5 more
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