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The RAS/RAF/ERK signal transduction pathway
1997Abstract The importance of RAS proteins in human cancer was established in 1982, when the first human oncogene was recognized to be a mutant version of a normal H-RAS allele (1). These early observations prompted exhaustive efforts to identify effectors of RAS proteins, and so to understand their precise molecular function. These efforts
Susan G Macdonald, Frank McCormick
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The ERK signaling pathway returns to the limelight in uveal melanomas
Pigment Cell & Melanoma Research, 2021Uveal melanoma (UM), arising from melanocytes which reside in the uveal tract, is the most common primary intraocular tumor in adults. Despite successful treatment of the primary lesion by proton therapy or enucleation, up to 50% of UM patients develop metastases, predominantly in the liver.
Imène Krossa +2 more
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Modulation of the ERK pathway of signal transduction by cysteine proteinase inhibitors
Journal of Cellular Biochemistry, 2000Cell proliferation requires the coordinate synthesis and degradation of many proteins. In addition to the well-characterized involvement of the proteasome in the degradation of several cell cycle-regulated proteins, it has been established that cysteine proteinases are also involved in the control of cell proliferation, but their role is currently not ...
C, Torres, M, Li, R, Walter, F, Sierra
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Annexin1 regulates the erythroid differentiation through ERK signaling pathway
Biochemical and Biophysical Research Communications, 2005K562 cells can be used as a model of erythroid differentiation on being induced by hemin. We found that the level of annexin1 gene expression was notably increased during this indicated process. To test the hypothesis that annexin1 can regulate erythropoiesis, K562 cell clones in which annexin1 was stably increased and was knocked down by RNAi were ...
Xiao-fang, Huo, Jun-Wu, Zhang
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Cisplatin induces platelet apoptosis through the ERK signaling pathway
Thrombosis Research, 2012Cisplatin (cis-diamminedichloroplatinum II) is one of the most widely used anti-tumor agents. However, cisplatin-based chemotherapy is usually accompanied by adverse side effects such as thrombocytopenia, and the mechanism remains unclear. Here we show that cisplatin induced several platelet apoptotic events including up-regulation of Bax and Bak, down-
Weilin, Zhang +6 more
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Post‐transcriptional regulation of the Ras‐ERK/MAPK signaling pathway
Journal of Cellular Physiology, 2011AbstractThe Ras‐ERK/MAP (Mitogen‐Activated Protein) kinase signaling pathway governs many cellular processes such as proliferation, differentiation, cell fate, homeostasis, and survival in all eukaryotes. Constitutive activation of the Ras‐ERK/MAPK signaling pathway often leads to promotion of abnormal cell growth and tumorigenesis.
Jarrett T, Whelan +4 more
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Silencing ERK Signaling Pathway in TNBC by Silencing BAG3
MedScien, 2023TNBC(Triple negative breast cancer) is cancer with a high mortality rate and recurrence rate. Other studies have shownthat overexpression of EGFR in TNBC is also associated with the overexpression of BAG3 and that silencing of BAG3will downregulate the expression of EGFR.
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Deciphering Signaling Pathways In Vivo: The Ras/Raf/Mek/Erk Cascade
2010The Ras/Raf/MEK/ERK cascade is a highly conserved signal transduction module, whose activation results in a number of different physiological outcomes. Depending on the cell type or the stimulus used, the pathway has been implicated in proliferation, differentiation, apoptosis, and migration.
Galabova-Kovacs, Gergana +1 more
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The ERK Cascade As a Prototype of MAPK Signaling Pathways
2004Hadara, Rubinfeld, Rony, Seger
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