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JSAP1 Suppresses the ERK MAPR Signaling Pathways
JSAP1 Suppresses the ERK MAPR Signaling Pathwaysopenaire +1 more source
MAPK/ERK Signaling Pathway in Hepatocellular Carcinoma [PDF]
Cancers, 2021 Hepatocellular carcinoma (HCC) is a major health concern worldwide, and its incidence is increasing steadily. Recently, the MAPK/ERK signaling pathway in HCC has gained renewed attention from basic and clinical researchers. The MAPK/ERK signaling pathway is activated in more than 50% of human HCC cases; however, activating mutations in RAS and RAF ...
Hyuk Moon +2 more
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Targeting the ERK Signaling Pathway in Melanoma
International Journal of Molecular Sciences, 2019 The discovery of the role of the RAS/RAF/MEK/ERK pathway in melanomagenesis and its progression have opened a new era in the treatment of this tumor. Vemurafenib was the first specific kinase inhibitor approved for therapy of advanced melanomas harboring BRAF-activating mutations, followed by dabrafenib and encorafenib.
Ottavio Cremona +2 more
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Nodakenin Inhibits Melanogenesis Via the ERK/MSK1 Signaling Pathway
Die Pharmazie, 2023The aim of the present study was to investigate the potential inhibitory effects of nodakenin, a coumarin glucoside derivative from the root extract of Angelica gigas Nakai (AGN), on melanogenesis and its underlying mechanisms in B16F10 melanoma cells.
Yeahwa Yoon, Yeahwa Yoon +4 more
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Valproate activates ERK signaling pathway in primary human hepatocytes [PDF]
Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia, 2014 Valproic acid (VPA) is a widely-used anticonvulsant and mood-stabilizing agent. VPA is also known to inhibit histone deacetylases (HDACs) affecting the expression of numerous genes.In the present study, we examined the effect of VPA on the extracellular signal-related kinase (ERK, p42/p44) pathway (Ras-Raf-MEK-ERK) belonging to the mitogen-activated ...
Petr Pavek +2 more
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Control of gastruloid patterning and morphogenesis by the Erk and Akt signaling pathways
Development, 2023Abstract Fibroblast growth factor (FGF) dependent elongation along an anterior-posterior (A-P) axis is a conserved feature of vertebrate embryogenesis. A-P axis elongation can also be reproduced in 3D cell culture models termed gastruloids, enabling dissection of this process in a controlled, minimal context.
Evan J. Underhill, Jared E. Toettcher
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PARP-1 activation in the ERK signaling pathway
Trends in Pharmacological Sciences, 2007PARP-1 is a highly conserved DNA-binding protein, the most abundant member of the polyADP-ribose polymerases (PARP) family, which catalyzes post-translational modification of proteins by polyADP-ribosylation. This modification affects protein-protein and protein-DNA interactions.
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Acta Histochemica, 2014
Chronic exposure to fluoride can result in a variety of adverse effects in fish. Previously we indicated that high fluoride caused damage and apoptosis in the kidneys of the common carp, Cyprinus carpio. In this study, the effects of fluoride on the expression and localization of ERK and p-ERK proteins in the ERK signaling pathway were determined using
Lingtian Xie +2 more
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Chronic exposure to fluoride can result in a variety of adverse effects in fish. Previously we indicated that high fluoride caused damage and apoptosis in the kidneys of the common carp, Cyprinus carpio. In this study, the effects of fluoride on the expression and localization of ERK and p-ERK proteins in the ERK signaling pathway were determined using
Lingtian Xie +2 more
exaly +3 more sources
Mathematical Modeling of the Influence of RKIP on the ERK Signaling Pathway
2003This paper investigates the influence of the Raf Kinase Inhibitor Protein (RKIP) on the Extracellular signal Regulated Kinase (ERK) signaling pathway through mathematical modeling and simulation. Using nonlinear ordinary differential equations to represent biochemical reactions in the pathway, we suggest a technique for parameter estimation, utilizing ...
Kwang-Hyun Cho +5 more
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Sorafenib regulating ERK signals pathway in gastric cancer cell
Environmental Toxicology and Pharmacology, 2014The involvement of ERK signals in gastric carcinoma was investigated using Western blot, MTT, and flow cytometric analysis in cultured cells SGC7901. Results showed that treatment of sorafenib potently inhibited gastric SGC7901 cells proliferation, migration, invasion as well as promoted apoptosis.
Liu Wei, Juan +4 more
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