Results 51 to 60 of about 184,535 (247)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Efficient measurement error mitigation with subsystem-balanced Pauli twirling
Physical Review ResearchMeasurement error mitigation (MEM) is essential for realizing reliable quantum computation. Model-free measurement error mitigation (MF-MEM) is an important class of MEM methods that employs Pauli twirling—typically with a random twirling set—to convert ...
Xiao-Yue Xu, Chen Ding, Wan-Su Bao
doaj +1 more source
k-dimensional error-free deconvolution using the fermat number transform
Computers & Mathematics with Applications, 1989 AbstractThe paper presents the generalization of the one-dimensional deconvolution algorithm using the Fermat number transform for the k-dimensional deconvolution. The problems of how to express a k-dimensional convolution system in the form of special matrix equation, how to calculate the precise value of the matrix determinant and how to remove ...
openaire +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Study of FPGA-based Error-controllable Floating-point Operation Accelerators [PDF]
Jisuanji gongchengFloating-point operations are fundamental operations in the field of High-Performance Computing(HPC). In the context of big data and cloud computing,the amount of data that HPC platforms need to process is continuously growing,and the round-off error of ...
GUAN Mingxiao, LIU Jiakun, ZHANG Hongrui, HE Anping
doaj +1 more source
A two-parameter hazard function to describe age patterns of mortality in ancient Northwestern Europe
Genus, 2021 When seeking to describe the age patterns of mortality for ancient populations, researchers are often confronted with small sample sizes or with missing data for several age groups.
Hugo J. P. La Poutré, Fanny Janssen
doaj +1 more source