Results 101 to 110 of about 82,940 (314)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Intersection Bounds: estimation and inference [PDF]

We develop a practical and novel method for inference on intersection bounds, namely bounds defined by either the infimum or supremum of a parametric or nonparametric function, or equivalently, the value of a linear programming problem with a potentially
Adam Rosen, Victor Chernozhukov, Sokbae 'Simon' Lee   +2 more
core   +2 more sources

Thermodynamic bounds and error correction for faulty coarse graining

Physical Review Research
At the nanoscale, random effects not only govern the dynamics of a physical system but may also affect its observation. This work introduces a paradigm for coarse graining that eschews the assignment of a unique coarse-grained trajectory to a microscopic
Jann van der Meer, Keiji Saito
doaj   +1 more source

Issues of Estimation in the Monitoring of Constant Flow Continuous Streams

, 1999
This paper deals with some fundamental matters pertaining to estimation of critical quantities associated with continuous processes which are frequently related to the quality rating of the product.
Dragomir, Sever S, Barnett, Neil S
core  

Error-Bounds on Curvature Estimation [PDF]

, 2003
Estimation of a digital curve's curvature at any given point is needed for many tasks in computer vision, be it differential invariants or curvature scale space. However, curvature estimation is known to be very susceptible to noise on the contour. We shall show how noise on the contour affects the relative accuracy of the curvature computation.
openaire   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Consistent estimation in an implicit quadratic measurement error model

, 2004
An adjusted least squares estimator is derived that yields a consistent estimate of the parameters of an implicit quadratic measurement error model. In addition, a consistent estimator for the measurement error noise variance is proposed.
Er Kukush, Sabine Van Hu-el, Van Huffel, S., Kukush, A., Ivan Markovsky, Markovsky, I.   +5 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Analysis On Simpson's Type Inequalities Through Generalized Convexity with Applications [PDF]

Sahand Communications in Mathematical Analysis
Fractional operators and integral inequalities have become a focal point of research due to their applications in mathematics, physics, engineering, and applied sciences.
Arslan Munir, Artion Kashuri
doaj   +1 more source

Converting approximate error bounds into exact ones

, 1995
In order to produce error bounds quickly and easily, people often apply to error bounds linearized propagation rules. This is done instead of a precise error analysis. The payoff: Estimates so produced are not guaranteed to be true bounds.
Abraham Ziv
core   +1 more source