Results 101 to 110 of about 59,745 (265)

Asymptotic Behavior of the Modulus of the Kernel and Error Bounds of Anti-Gaussian Quadrature Formulas with Jacobi Weights

Mathematics
In this paper, the remainder term of anti-Gaussian quadrature rules for analytic integrands with respect to Jacobi weight functions ωa,b(x)=(1−x)a(1+x)b, where a,b>−1, is analyzed, and sharp estimates of the error are provided.
Ramon Orive, Ljubica Mihić, Aleksandar Pejčev, Miroslav Pranić, Stefan Spalević   +4 more
doaj   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Some New and Sharp Inequalities of Composite Simpson’s Formula for Differentiable Functions with Applications

Mathematics
Composite integral formulas offer greater accuracy by dividing the interval into smaller subintervals, which better capture the local behavior of function. In the finite volume method for solving differential equations, composite formulas are mostly used
Wei Liu, Yu Wang, Ifra Bashir Sial, Loredana Ciurdariu   +3 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Error Estimation of Weddle’s Rule for Generalized Convex Functions with Applications to Numerical Integration and Computational Analysis

Mathematics
This paper presents new integral inequalities for differentiable generalized convex functions in the second sense, with a focus on improving the accuracy of Weddle’s formula for numerical integration.
Abdul Mateen, Bandar Bin-Mohsin, Ghulam Hussain Tipu, Asia Shehzadi   +3 more
doaj   +1 more source

Learning with Known Operators reduces Maximum Training Error Bounds. [PDF]

Nat Mach Intell, 2019
Maier AK, Syben C, Stimpel B, Würfl T, Hoffmann M, Schebesch F, Fu W, Mill L, Kling L, Christiansen S.   +9 more
europepmc   +1 more source