Results 81 to 90 of about 531,785 (265)

Azimuth estimation based on CNN and LSTM for geomagnetic and inertial sensors data

open access: yesICT Express
Although estimating the azimuth using a geomagnetic sensor is very useful, the estimation error may be very large due to the surrounding geomagnetic disturbance.
Jongtaek Oh, Sunghoon Kim
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

Impact of Measurement Error on Residual Extropy Estimation

open access: yesAxioms
In scientific analyses, measurement errors in data can significantly impact statistical inferences, and ignoring them may lead to biased and invalid results.
Radhakumari Maya   +3 more
doaj   +1 more source

Tensor-Based Angle and Array Gain-Phase Error Estimation Scheme in Bistatic MIMO Radar

open access: yesIEEE Access, 2019
This paper investigates the issue of angle and array gain-phase error estimation in multiple-input-multiple-output (MIMO) radar, and a tensor-based angle and gain-phase error estimation scheme is proposed.
Yuehao Guo   +6 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Research on negative feedback amplifier circuit gain error of the estimate

open access: yesDianzi Jishu Yingyong, 2019
In engineering applications, the gain of a negative feedback amplifying circuit is commonly obtained by an estimation method. The negative feedback amplifying circuit examples of various configurations are selected, and the voltage gain is estimated and ...
Lu Houyuan
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

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