Results 51 to 60 of about 208,269 (282)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Controlled fluorescence quenching by antibody-conjugated graphene oxide to measure tau protein [PDF]
Royal Society Open Science, 2018 We report an ultrasensitive immunoassay for tau protein—a key marker of Alzheimer's disease. This sensing platform relies on graphene oxide (GO) surfaces conjugated with anti-human tau antibody to provide quantitative binding sites for the tau protein ...
Ao Huang +5 more
doaj +1 more source
Entanglement Stabilization using Parity Detection and Real-Time Feedback in Superconducting Circuits
, 2019 Fault tolerant quantum computing relies on the ability to detect and correct errors, which in quantum error correction codes is typically achieved by projectively measuring multi-qubit parity operators and by conditioning operations on the observed error
Andersen, Christian Kraglund +8 more
core +1 more source
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Stabilized Cat in a Driven Nonlinear Cavity: A Fault-Tolerant Error Syndrome Detector
Physical Review X, 2019 In quantum error correction, information is encoded in a high-dimensional system to protect it from the environment. A crucial step is to use natural, two-body operations with an ancilla to extract information about errors without causing backaction on ...
Shruti Puri +9 more
doaj +1 more source
Error Correction in Dynamical Codes [PDF]
QuantumWe ask what is the general framework for a quantum error correcting code that is defined by a sequence of measurements. Recently, there has been much interest in Floquet codes and space-time codes.
Esther Xiaozhen Fu, Daniel Gottesman
doaj +1 more source
Bladder Pain Syndrome: A Review
European Medical Journal Urology, 2020 Therapy of bladder pain syndrome (BPS) presents a significant challenge in clinical practice. Over the last 20 years, there have been important efforts directed at understanding the syndrome’s aetiology and therapeutic challenges.
Gokhan Calik, Jean de la Rosett
doaj +1 more source
Diagnostic error: what Muir-Torre syndrome has taught us [PDF]
BMJ Case Reports, 2015 A low-grade sebaceous carcinoma was excised from a 55-year-old woman's neck. At follow-up, 11 months later, a recent diagnosis of mucinous adenocarcinoma of the colon and history of clear cell endometrial carcinoma were identified. A strong family history of bowel cancer suggested Muir-Torre syndrome.
Dmitri Wall +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source