Results 81 to 90 of about 780,296 (293)

Isolated methylmalonic acidemia in Mexico: Genotypic spectrum, report of two novel MMUT variants and a possible synergistic heterozygosity effect

Molecular Genetics and Metabolism Reports
Isolated methylmalonic acidemia (iMMA) is a group of monogenic metabolic disorders affecting methylmalonate and cobalamin metabolism. Five iMMA-responsible genes have been described to date: MMUT (MIM *609058), MMAA (MIM *607481, MMAB (MIM *607568 ...
Cynthia Fernández-Lainez, Marcela Vela-Amieva, Miriam Reyna-Fabián, Liliana Fernández-Hernández, Sara Guillén-López, Lizbeth López-Mejía, Miguel Ángel Alcántara-Ortigoza, Ariadna González-del Angel, Rosa Itzel Carrillo-Nieto, Enrique Ortega-Valdez, Mauricio Rojas-Maruri, Cecilia Ridaura-Sanz   +11 more
doaj   +1 more source

102 errores en valoraciones de empresas [PDF]

Este documento de investigación es una recolección de 102 errores cometidos en distintas valoraciones de empresas. La mayor parte de las valoraciones que aparecen referidas en el documento proceden de valoraciones a las que el autor ha tenido acceso al ...
Fernandez, Pablo
core  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Errores en el razonamiento deductivo silogístico [PDF]

, 2016
En el marco de la investigación en psicología del razonamiento se distingue entre inferencias deductivas e inductivas. Entre las primeras, se ha estudiado el razonamiento silogístico, el transitivo y el razonamiento con el condicional, aunque este último
D´Andrea, Rodolfo Eliseo, Rey, Graciela, Sastre, Patricia   +2 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Errores y dificultades frecuentes al aplicar las técnicas de conteo (Frequent errors and difficulties in applying counting techniques)

Revista Digital Matemática, Educación e Internet
Los errores y dificultades frecuentes que presentan los estudiantes de Estadística I en la UDO Anzoátegui, al aplicar técnicas de conteo, se encuentran, en su mayoría, al resolver problemas de combinación y permutación.
Manuel Vicente Centeno Romero, Marvelis González Rodríguez   +1 more
doaj   +1 more source

Análisis y clasificación de errores cometidos por alumnos de secundaria en los procesos de sustitución formal, generalización y modelización en álgebra [PDF]

, 2003
EN esta ponencia se presenta un estudio con alumnos de Educación Secundaria sobre tres procesos específicos del lenguaje algebraico: la sustitución formal, la generalización y la modelización.
Palarea, María Mercedes, Ruano, Raquel M., Socas, Martín   +2 more
core  

Dificultades en la resolución de problemas multiplicativos [PDF]

, 2013
El presente trabajo de investigación tiene como fin mostrar la descripción de las dificultades y los errores que presentan los estudiantes al realizar diferentes problemas multiplicativos.
Guerrero, Yeison, Rey, Andrea
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source