Results 61 to 70 of about 601,288 (278)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Spherical Regression with Errors in Variables

open access: yesThe Annals of Statistics, 1989
Suppose \(u_ 1,...,u_ n\), \(v_ 1,...,v_ n\) are random points on the sphere such that for unknown points \(\xi_ 1,...,\xi_ n\) and unknown rotation \(A_ 0\), the distribution of \(u_ i\) depends only on \(u^ t_ i\xi_ i\) and that of \(v_ i\) on \(v^ t_ iA_ 0\xi_ i\).
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Errors-in-Variables Anisotropic Extended Orthogonal Procrustes Analysis [PDF]

open access: yes, 2017
This letter presents a novel total least squares (TLS) solution of the anisotropic row-scaling Procrustes problem. The ordinary LS Procrustes approach finds the transformation parameters between origin and destination sets of observations minimizing ...
Crosilla, Fabio   +2 more
core   +1 more source

Value and limitations of intracranial recordings for validating electric field modeling for transcranial brain stimulation

open access: yesNeuroImage, 2020
Comparing electric field simulations from individualized head models against in-vivo intra-cranial recordings is considered the gold standard for direct validation of computational field modeling for transcranial brain stimulation and brain mapping ...
Oula Puonti   +3 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Prediction of treatments effects in a biased allocation model

open access: yesRevstat Statistical Journal, 2005
Robbins and Zhang [15] provide consistent estimators of multiplicative treatment effects under a biased treatment allocation scheme, and illustrate their methodology within Poisson and binomial models.
Fernando J.M. Magalhães
doaj   +1 more source

Estimation of the mean of the partially linear single-index errors-in-variables model with missing response variables

open access: yesJournal of Inequalities and Applications, 2020
In this paper, we estimate the mean of the partially linear single-index errors-in-variables model with missing response variables. The linear covariate is measured with additive error, therefore missing is not random.
Xin Qi, ZhuoXi Yu
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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