Results 141 to 150 of about 116,869 (268)

Phytochemicals as Multitarget Therapeutics in Pancreatic Cancer: Mechanisms, Clinical Evidence, and Translational Challenges

Phytotherapy Research, EarlyView.
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is aggressive and often diagnosed late, making treatment challenging. This review highlights the potential of phytochemicals, such as curcumin and quercetin, as multitarget agents that influence key carcinogenic pathways. These compounds exhibit anticancer effects by inhibiting processes
Md. Rezaul Islam, Abdur Rauf, F. M. Shourav, Hanan A. Ogaly, Abdullah S. M. Aljohani, Waleed Al Abdulmonem, Kamala Badalova, Marcello Iriti   +7 more
wiley   +1 more source

FLASH Radiotherapy and Organelle-Targeted Radiosensitization in Glioblastoma: A Conceptual and Translational Review. [PDF]

Cancers (Basel)
Tang X, Wang X, Xiao K, Zhu B, Lin F, Zhou L.   +5 more
europepmc   +1 more source

Clinical Outcomes and Acute Exacerbation Incidence in Combined Pulmonary Fibrosis and Emphysema

Respirology, EarlyView.
This multicentre prospective study of 1016 patients demonstrated that CPFE, defined as ≥ 5% emphysema on visual CT assessment, identified a high‐risk phenotype with significantly worse 5‐year survival compared to non‐CPFE IIP patients (51.4% vs. 63.1%) and COPD patients (51.4% vs. 84.0%) and higher acute exacerbation incidence, validating international
Kazuya Tsubouchi, Yasuaki Kotetsu, Tomotsugu Takano, Hiroaki Ogata, Fumiaki Kiyomi, Katsuyuki Ichiki, Shohei Takata, Yasuhiko Kitasato, Hiroshi Ishii, Kazuhiro Yatera, Kei Yamasaki, Masaki Okamoto, Makoto Yoshida, Masayuki Kawasaki, Masaki Fujita, Tomohiro Ogawa, Kazunori Tobino, Eiji Harada, Noriaki Nakagaki, Masashi Komori, Taishi Harada, Hiroshi Wataya, Yoichi Nakanishi, Isamu Okamoto   +23 more
wiley   +1 more source

Imperatorin ameliorates myocardial ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress-mediated apoptosis via the PI3K/AKT/Nrf2 pathway. [PDF]

J Cell Commun Signal
Han M, Yu F, Li H.
europepmc   +1 more source

Three Spirometry‐Based At‐Risk Phenotypes Predict Incident Airflow Limitation: A Population‐Based Study

Respirology, EarlyView.
Analysing the population‐based KORA and SHIP studies, three spirometric at‐risk subtypes (early airflow limitation, PRISm, and small airway dysfunction) were consistently associated with incident airflow limitation. Their combination in a conceptual framework identified most future cases with high negative predictive value, suggesting potential for ...
Hendrik Pott, Roman Martin, Wilhelm Bertrams, Mustafa Abdo, Margit Heier, Annette Peters, Beate Stubbe, Max Kutzinski, Anne Obst, Ralf Ewert, Dominik Heider, Henry Völzke, Gernot Rohde, Claus F. Vogelmeier, Bernd Schmeck, Stefan Karrasch, on behalf of the KORA‐study group   +16 more
wiley   +1 more source

How Extreme Is It Anyways?: An Empirical Investigation Into the Prevalence and Strength of Extreme Response Style. [PDF]

Educ Psychol Meas
Schoenmakers M, Tijmstra J, Vermunt JK, Bolsinova M.   +3 more
europepmc   +1 more source

Oxidative stress and endoplasmic reticulum stress in acute kidney injury: mechanistic crosstalk and therapeutic modulation. [PDF]

Front Med (Lausanne)
Xu X, Xing Q, Li H, Ding Z, Ren X.
europepmc   +1 more source

Bridging Global Sustainability Objectives With Corporate Reporting Standards: Sustainable Development Goals Meet European Sustainability Reporting Standards

Sustainable Development, EarlyView.
ABSTRACT Given the complexity of the Sustainable Development Goals (SDGs), aligning corporate sustainability with them can be challenging. Drawing on systems thinking, this study examines how the European Sustainability Reporting Standards (ESRS) align with the SDGs and bridge macro‐level global goals with firm‐level metrics.
Chonlawan Thammaraksa, Caroline Aggestam Pontoppidan, Michael Zwicky Hauschild, Alexis Laurent   +3 more
wiley   +1 more source

Research hotspots and emerging trends in the regulation of endoplasmic reticulum stress by traditional Chinese medicine: A bibliometric analysis perspective. [PDF]

Medicine (Baltimore)
Qian J, Yang W, Wang S, Xue H, Wu C.
europepmc   +1 more source

Waste Management Strategies for Environmental Wellbeing: Exploring the Roles of Environmental Regulations and Green Finance in Reducing Carbon Intensity

Sustainable Development, EarlyView.
ABSTRACT Rising industrial activity, urban expansion, and economic growth continue to intensify waste generation and greenhouse gas emissions, placing growing pressure on environmental sustainability. In this setting, reducing the carbon intensity of electricity generation has become a key policy priority, particularly in advanced economies pursuing ...
Abdullah Emre Caglar, Mehmet Akif Destek, Ismail Demirdag, Muge Manga, Sercan Aydın   +4 more
wiley   +1 more source