Results 221 to 230 of about 1,872,205 (309)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

Allergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake, Alexandra C. Brown, Nikhil T. Awatade, Philip M. Hansbro, Katherine J. Baines, Richard Y. Kim, Nathan W. Bartlett, Jay C. Horvat, Peter A. B. Wark   +8 more
wiley   +1 more source

Targeting endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights and emerging therapies. [PDF]

Biol Res
Weng J, Guo R, Liu D, Huang S, Weng S.
europepmc   +1 more source

Economic burden of pulmonary arterial hypertension in Switzerland. [PDF]

PLoS One
Tomonaga Y, Lichtblau M, Ulrich S, Guler SA, Yerly P, Lechartier B, Fellrath JM, Bergeron A, Bondeelle L, Chirila SM, Favre-Bulle A, Stoffel S, Schwenkglenks M.   +12 more
europepmc   +1 more source

Peroxiredoxin 4 Involved in Spermatogenesis by Affecting Oxidative Stress and Ferroptosis

Andrology, EarlyView.
ABSTRACT Background The main functions of testes are sperm production and androgen secretion in testicular befitting microenvironment. Excessive level of the reactive oxygen species (ROS) from metabolism and cellular events can lead to oxidative stress (OS) and ferroptosis, which injure the functions of mitochondria and endoplasmic reticulum (ER) of ...
Shuning Yuan, Nini Wei, Weiwei Ma, Mengting Hu, Bei Zhang, Li Gao, Chao Gao, Xiaoyu Yang, Yan Meng, Jiayin Liu, Yugui Cui   +10 more
wiley   +1 more source

Identification and verification of diagnostic biomarkers related to endoplasmic reticulum stress for atherosclerosis. [PDF]

BMC Cardiovasc Disord
Liu X, Pang H, Pan X, Fan S, Deng Y, Yu M, Xie X, Pan Y.   +7 more
europepmc   +1 more source

IRT‐based response style models and related methodology: Review and commentary

British Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract We provide a review and commentary on recent methodological research related to item response theory (IRT) modelling of response styles in psychological measurement. Our review describes the different categories of IRT models that have been proposed, their associated assumptions and extensions, and the varying purposes they can serve.
Daniel M. Bolt, Lionel Meng
wiley   +1 more source

Linking movement-related beta oscillations to cortical excitability, structural damage, and fatigue in multiple sclerosis. [PDF]

Brain Commun
Tatti E, Benelli A, Cinti A, Cortese R, Serbina A, Kulapurathazhe AJ, Saed S, Luchetti L, Cudeiro J, Zhang J, de Mauro A, Neri F, Stromillo ML, Baldi TL, d'Aurizio N, Battaglini M, Plantone D, Righi D, Massucco E, Giannotta A, Lomi F, Scoccia A, Lai G, Ulivelli M, Ghilardi MF, De Stefano N, Rossi S.   +26 more
europepmc   +1 more source

mTOR pathway mediates the endoplasmic reticulum stress -apoptosis of CD4+ T cell through inhibiting autophagy flux in sepsis. [PDF]

Inflamm Res
Lei X, Zhao G, Xie Y, Cui N.
europepmc   +1 more source

Comparison of Diagnostic and Therapeutic Protocols for Chronic Obstructive Pulmonary Disease (COPD): Global Initiative for Chronic Obstructive Lung Disease (GOLD) vs. American Thoracic Society/European Respiratory Society (ATS/ERS) Guidelines. [PDF]

Cureus
Basoshvili N.
europepmc   +1 more source

The Role of Crosstalk Between the Unfolded Protein Response and Autophagy in Diseases Associated with Sympathetic Nervous System Imbalance: Mechanisms and Therapeutic Perspectives. [PDF]

Int J Mol Sci
Xu B, Yang Y, Wang R.
europepmc   +1 more source