Results 41 to 50 of about 31,797 (187)

Type 2 leprosy reaction presenting as a monoarthritis post multidrug therapy

IDCases, 2022
Type 2 leprosy reaction, or erythema nodosum leprosum (ENL), involves a complex interaction between the host's immune system and Mycobacterium leprae.
Isabela Maria Bernardes Goulart, Marcela Araujo de Oliveira Santana, Willian Vargas Tenório da Costa, Matthew Martin Pavelka, Bruno de Carvalho Dornelas   +4 more
doaj   +1 more source

Erythema Nodosum Leprosum diagnoses.

, 2012
*Erythema Nodosum Leprosum.NB: This gives sensitivity 1/13 = 0.154 and specificity 1.0. Numbers could be added to the test, though N is small (Page 12).
Wim van Brakel (155684), Peter Nicholls (155649), Loretta Das (155664), Pramila Barkataki (155673), Diana N. J. Lockwood (155640), Sujai Suneetha (155693), W. Cairns S. Smith (155656)   +6 more
core   +1 more source

Plasma Exchange in Severe Erythema Nodosum Leprosum

, 1986
Four patients with severe erythema nodosum leprosum were treated by plasma exchange and/or fresh frozen plasma infusions after failure of classical therapy.
P. Koch, J. Pennec, A. Bussel, D. Wallach, F. Cottenot   +4 more
core   +1 more source

Cytokine and protein markers of leprosy reactions in skin and nerves: baseline results for the North Indian INFIR cohort. [PDF]

, 2011
BACKGROUND: Previous studies investigating the role of cytokines in the pathogenesis of leprosy have either been on only small numbers of patients or have not combined clinical and histological data.
Lavanya Suneetha, Mohammed Ismail, Ismail Mohammed, Suneetha Lavanya, Diana N J Lockwood, Nicholls, Peter, Chaduvula Meher Vani, Smith W. C., Wim van Brakel, Diana N. J. Lockwood, Lockwood, Diana NJ, Sagili Karuna Devi, Smith, WC, Mohammed, Ismail, Suneetha, Sujai, Suneetha Sujai, van Brakel Wim, Suneetha, Lavanya, Sagili, Karuna Devi, van Brakel, Wim, Karuna Devi Sagili, Sujai Suneetha, Lockwood Diana N. J., Nicholls Peter, W. C. Smith, W C Smith, Chaduvula, Meher Vani, Peter Nicholls, Meher Vani Chaduvula   +28 more
core   +2 more sources

Erythema nodosum leprosum [PDF]

Internet Journal of Rheumatology and Clinical Immunology, 2016
Erythema nodosum leprosum (ENL) is a type 2 reaction, which is a humoral response to  Mycobacterium Leprae infection. The fig. 1 and 2 depict the presentation of a 30-year-old with arthritis of large joints and dactylitis. Since 2 years, he had progressive nodular ulcerative lesions over trunks, thighs and upper-extremities (Fig.
openaire   +1 more source

Um caso pouco comum de erythema nodosum leprosum

Hansenologia Internationalis, 1981
No presente trabalho descreve-se e comenta-se uma manifestação pouco comum de erythema nodosum leprosum (ENL) em uma mulher de 24 anos, cuja história e quadro clínico não sugeriam hanseníase, mas lupus eritematoso sistêmico em fase de agudização.
Valeria PETRI
doaj   +1 more source

IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts [PDF]

, 1997
The aim of the present work was to evaluate the levels of anti-PGL-I and anti-10-kDa heat shock protein antibodies in serum and immune complexes isolated from leprosy patients, convivients and controls.
R.E. Rojas, Segal-Eiras, Amada, E.N. Sarno, A. Segal-Eiras, Sarno, E. N., Demichelis, Sandra O., S.O. Demichelis, Rojas, R. E.   +7 more
core   +1 more source

Complement C1q expression in Erythema nodosum leprosum.

PLoS Neglected Tropical Diseases, 2018
Complement C1q is a soluble protein capable of initiating components of the classical pathway in host defence system. In earlier qualitative studies, C1q has been implicated in the pathogenesis of Erythema Nodosum Leprosum (ENL). However, little is known
Edessa Negera, Stephen L Walker, Tsehaynesh Lema, Abraham Aseffa, Diana N Lockwood, Hazel M Dockrell   +5 more
doaj   +1 more source

PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation

International Journal of Dermatology, Volume 65, Issue 10, Page 2038-2048, October 2026.
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad, Nicole E. Chin, Raj Chovatiya   +2 more
wiley   +1 more source

Charting Morphotoxicity With Complementary Embryo Models

Advanced Healthcare Materials, Volume 15, Issue 35, 18 September 2026.
Three human embryo models of the peri‐implantation stages are exposed to a library of compounds. The (toxic) effects of the compounds are analyzed through automated image analysis pipelines. By evaluating the differential responses of the embryo models, this study underscores the importance of testing complementary embryo models to achieve robust and ...
Dorian G. Luijkx, Pauline L. Balder, Romy M. L. Verhagen, Vinidhra Shankar, Barry Jutten, Pinak Samal, Timo Rademakers, Clemens A. van Blitterswijk, Stefan Giselbrecht, Erik J. Vrij   +9 more
wiley   +1 more source