Results 71 to 80 of about 31,797 (187)

Drug Discovery Approaches to Target E3 Ligases

ChemBioChem, Volume 26, Issue 1, January 2, 2025.
Comprehensive review presenting the different drug discovery approaches that until now have been employed in academic and pharmaceutical settings to identify new E3 ligase small molecules ligands and contributing to the expansion of the targeted protein degradation field. Abstract Targeting E3 ligases is a challenging area in drug discovery.
Alejandra Rodríguez‐Gimeno, Carles Galdeano   +1 more
wiley   +1 more source

Bullous Type 2 Lepra Reaction: A Rare and Significant Case Report

Clinical Case Reports, Volume 13, Issue 1, January 2025.
ABSTRACT Bullous type 2 lepra reactions are a rare initial presentation in leprosy that can complicate the disease with vesiculo‐bullous lesions. Early recognition and differentiation from other bullous disorders are critical for timely corticosteroid and multidrug therapy initiation to improve patient outcomes.
Hrithik Dakssesh Putta Nagarajan, Balakrishnan Kamaraj, Keerthivasan Selvanathan, Pruthvi Raj Kukunoor, Katta Manichandana, Katta Manideep, Biki Kumar Sah   +6 more
wiley   +1 more source

Lepromatous leprosy with erythema nodosum leprosum as immune reconstitution inflammatory syndrome in an HIV-1 infected patient after initiation of antiretroviral therapy

, 2009
We present the case of an HIV infected male patient with erythema nodosum leprosum and function loss of the peroneus nerve as manifestations of lepromatous leprosy.
Cusini, A, H. F Gunthard, M. Huber, B. Beck, Weber, R, Kamarashev, J, A. Cusini, R. Weber, Günthard, H F, S. Peter, Bertisch, B, Peter, S, Beck, B, Huber, M, B. Bertisch, J. Kamarashev, Bertisch B, Peter S, Cusini A, Kamarashev J, Beck B, Günthard HF, Huber M, Weber R   +23 more
core   +1 more source

Immunoglobulin deposits in Erythema Nodosum Leprosum (ENL) JOSEPHINE ANTHON

Hansenologia Internationalis, 1978
Erythema Nodosum Leprosum (ENL) skin lesions observed by fluorescence microscopy were found to contain immune complexes. While biopsies taken from at least seven ENL lesions contained deposits of immunoglobulin in their vessel walls, twelve of the ...
JOSEPHINE ANTHONY, M. C. VAIDYA, A. DASGUPTA   +2 more
doaj   +1 more source

From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases

Advances in Pharmacological and Pharmaceutical Sciences, Volume 2025, Issue 1, 2025.
Drug repurposing, the process of identifying new therapeutic uses for existing drugs, has emerged as a cost‐effective and time‐saving alternative to traditional drug development. This strategy leverages the known pharmacological and safety profiles of approved or investigational drugs to accelerate their clinical application for other diseases.
Md Sadique Hussain, Prince Ahad Mir, Nishant Kumar, Roohi Mohi-ud-din, Adil Farooq Wali, Reyaz Hassan Mir, Sirajunisa Talath, Sathvik B. Sridhar, Javedh Shareef, Manjunatha Goud, Imran Rangraze, Mohamed El-Tanani, Der Jiun Ooi   +12 more
wiley   +1 more source

Rationale use of Thalidomide in erythema nodosum leprosum - A non-systematic critical analysis of published case reports

Revista da Sociedade Brasileira de Medicina Tropical, 2020
INTRODUCTION: Thalidomide is an anti- tumor necrosis factor alpha (TNF-a) drug used mainly in the management of moderate to severe form of Erythema Nodosum Leprosum (ENL).
Pugazhenthan Thangaraju, Sajitha Venkatesan, Meenalotchini Gurunthalingam, Shoban Babu, Tamilselvan T   +4 more
doaj   +1 more source

Uncommon Presentation of Lepromatous Leprosy in a Nonendemic Setting: A Case Report

Case Reports in Medicine, Volume 2025, Issue 1, 2025.
Leprosy, caused by Mycobacterium leprae, remains a significant public health concern in certain endemic regions, but it is rarely encountered in nonendemic areas, posing diagnostic challenges. This case report discusses an unusual presentation of lepromatous leprosy in a patient residing in Saudi Arabia with no history of travel to endemic regions. The
Mhdia Elhadi Osman, Tareq Nafea Alharby, Yasser Alhabeeb, Ayman Elshenawy, Hala Ghazi Alreshidi, Saja Saleem Saja Saleem Alhayeti, Areej Alhumaidi Alshammari, Shamimul Hasan   +7 more
wiley   +1 more source

IgM anti-phenolic glycolipid I and IgG anti-10-kDa heat shock protein antibodies in sera and immune complexes isolated from leprosy patients with or without erythema nodosum leprosum and contacts

, 2022
The aim of the present work was to evaluate the levels of anti-PGL-I and anti-10-kDa heat shock protein antibodies in serum and immune complexes isolated from leprosy patients, convivients and controls.
Segal-Eiras, Amada, Sarno, E. N., Demichelis, Sandra O., Rojas, R. E.   +3 more
core  

Thalidomide used by patients with erythema nodosum leprosum [PDF]

, 2010
Thalidomide is a drug currently used in Brazil for treating erythema nodosum leprosum. Methods: This was a prospective study to follow up clinical evolution, record adverse events and determine plasma thalidomide levels from a dose of 100 mg/day ...
VIEIRA, José Luiz Fernandes, VALENTE, Maria do Socorro da Silva   +1 more
core   +1 more source

Is it lucio phenomenon or necrotic erythema nodosum leprosum?

Indian Journal of Dermatology, 2013
Lucio phenomenon (LP) or erythema necroticans is a relatively rare, peculiar reaction pattern occurring in untreated lepromatous (LL) or borderline lepromatous (BL) leprosy cases.
PSS Ranugha, Laxmisha Chandrashekar, Rashmi Kumari, Devinder M Thappa, Bhawana Badhe   +4 more
doaj   +1 more source