Results 91 to 100 of about 29,567 (256)
Cell Communication and Signaling, 2023 Anemia is the most common manifestation in myelodysplastic syndrome (MDS) patients, but the cause of ineffective hematopoiesis is not fully understood. Enucleation is an important event in the maturation process of erythroblasts. According to a series of
Chao An +5 more
doaj +1 more source
Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]
, 1990 In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias +2 more
core
A dynamic intron retention program enriched in RNA processing genes regulates gene expression during terminal erythropoiesis [PDF]
, 2015 Differentiating erythroblasts execute a dynamic alternative splicing program shown here to include extensive and diverse intron retention (IR) events.
Conboy, John G. +5 more
core +1 more source
British Journal of Haematology, EarlyView.This review highlights how studies on animal red cells have enriched our understanding of the behaviour of those from humans. A comparative perspective has enhanced our knowledge of human red cell pathophysiology Summary This review emphasises how studies on animal red cells have enriched our understanding of the behaviour of those from humans.
Kathleen M. Connolly +5 more
wiley +1 more source
Calcium Signaling Is Required for Erythroid Enucleation. [PDF]
PLoS ONE, 2016 Although erythroid enucleation, the property of erythroblasts to expel their nucleus, has been known for 7ore than a century, surprisingly little is known regarding the molecular mechanisms governing this unique developmental process.
Christina B Wölwer +3 more
doaj +1 more source
Erythrocytes and erythroblasts give up iron.
Blood, 2018 In this issue of Blood, by comparing wild-type vs erythroid-specific ferroportin knockout mice, Zhang et al1 have shown that ferroportin-mediated export of iron from erythroblasts and erythrocytes contributes to the systemic iron economy and prevents ...
T. Ganz
semanticscholar +1 more source
Studies on the DNA metabolism of erythroid cell. II. Decrease in DNA contents and DNA synthetic rate during erythroid cell specialization [PDF]
, 1970 For the purpo3e to determine exactly what stage of cell specialization the DNA level of erythroid cell nuclei begins to decline, the author observed the DNA level of erythroblasts in mitosis by microspectrophotometry and the DNA synthesis by flash ...
Inoue, Masanao
core +1 more source
Roles of TIF1β in Leukemic Stem Cell Through SETDB1‐Dependent and Independent Mechanisms
Cancer Science, EarlyView.In leukemic stem cell, BCR::ABL cooperates with TIF1β to open chromatin at oncogenes and close chromatin at differentiation regulators, driving leukemic reprogramming. In TIF1β‐deficient stem cell, the loss of TIF1β inverts this balance, showing closed chromatin at oncogenes and open chromatin at differentiation regulators.
Mariko Morii, Sho Kubota, Goro Sashida
wiley +1 more source
Perspectives In Medical Research, 2017 Acute Erythroid Leukemia (AEL) / Acute Myeloid Leukemia M6 (AML M6) is a rare disorder of hematopoietic system and accounts for 1-3% of acute leukemia and 15% of myeloid leukemia. It is characterized by uncontrolled proliferation of erythroblasts and
Pendurthy Anoosha1 , Anandam G2 ,Preethi Soni3
doaj
Study on sideroblasts as a determination method of the erythropoietic function of bone marrow [PDF]
, 1958 With the purpose to study sideroblasts as a means of diagnosing blood diseases and to pursue the metabolism of non-hemin iron in erythroblasts we investigated sideroblasts (erythroblasts containing iron granules stainable by Prussian blue) under various ...
Hiraki, Kiyoshi, Kimura, Ikuro
core +1 more source