Results 211 to 220 of about 1,670,611 (336)

KRAS Withdrawal in Cholangiocarcinoma Leads to Immune Infiltration and Tumor Regression

open access: yesAdvanced Science, EarlyView.
Cholangiocarcinoma (CCA) driven by oncogenic KRAS depends on its continuous activation for tumor maintenance. Using a conditional KRAS model, the authors show that turning off KRAS triggers rapid tumor regression accompanied by immune cell infiltration and cytokine release. The findings uncover a KRAS–senescence–immune signaling axis and highlight KRAS
Youwei Qiao   +9 more
wiley   +1 more source

Full blood count as an ancillary test to support the diagnosis of giant cell arteritis

open access: yesInternal medicine journal (Print), 2018
L. Oh   +5 more
semanticscholar   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

open access: yesAdvanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He   +17 more
wiley   +1 more source

Red Blood Cells Internalize Extracellular DNA via Apoptotic Bodies with Clinical Relevance to Cancer Patients

open access: yesAdvanced Science, EarlyView.
Mature red blood cells (RBCs) can capture extracellular DNA, with short fragments homologous to cfDNA. This uptake is mediated by apoptotic bodies, which induce RBC oxidative stress, deformation, and accelerated in vivo clearance. The rbcDNA abundance correlates with tumor burden and therapeutic response, highlighting its potential as a liquid biopsy ...
Zihang Zeng   +20 more
wiley   +1 more source

Urinary carbonic anhydrase 1 as a marker of hematuria in IgA nephropathy. [PDF]

open access: yesNephrol Dial Transplant
Post TGJM   +6 more
europepmc   +1 more source

New Definition for Periprosthetic Joint Infection: From the Workgroup of the Musculoskeletal Infection Society

open access: yesClinical Orthopaedics and Related Research, 2011
J. Parvizi   +9 more
semanticscholar   +1 more source

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