Results 91 to 100 of about 2,250,672 (421)

Double Cross‐Linked Hydrogel for Intra‐articular Injection as Modality for Macrophages Metabolic Reprogramming and Therapy of Rheumatoid Arthritis

Advanced Functional Materials, EarlyView.
A hydrogel for intra‐articular injection for the treatment of rheumatoid arthritis (RA) is formulated and comprehensively studied. After administration, the hydrogel induces a metabolic reprogramming of immunometabolism of macrophages to trigger fatty acid oxidation subsequently inducing polarization of anti‐inflammatory M2 macrophages. This results in
Yutong Song, Valentin A. Milichko, Ziqiao Ding, Wen Li, Bei Kang, Yunsheng Dou, Sona Krizkova, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Mechanism of hypoxia-induced damage to the mechanical property in human erythrocytes—band 3 phosphorylation and sulfhydryl oxidation of membrane proteins

Frontiers in Physiology
Introduction: The integrity of the erythrocyte membrane cytoskeletal network controls the morphology, specific surface area, material exchange, and state of erythrocytes in the blood circulation.
Qinqin Yang, Dong Chen, Chungong Li, Runjing Liu, Xiang Wang   +4 more
doaj   +1 more source

Effects of rigidity on tension within the cell membranes of erythrocytes swollen by osmotic shock

Journal of Biomechanical Science and Engineering, 2021
Erythrocytes swell owing to the osmotic shock caused by hypotonic liquids, and when the membrane tension exceeds a certain limit, hemolysis occurs. The base tension in the membrane of a spherically shaped erythrocyte is usually ignored in the mechanical ...
Kiyoshi BANDO, Ryoko OTOMO
doaj   +1 more source

Mathematical modeling to elucidate brain tumor abrogation by immunotherapy with T11 target structure [PDF]

, 2014
T11 Target structure (T11TS), a membrane glycoprotein isolated from sheep erythrocytes, reverses the immune suppressed state of brain tumor induced animals by boosting the functional status of the immune cells. This study aims at aiding in the design of more efficacious brain tumor therapies with T11 target structure.
arxiv   +1 more source

Loading and relaxation dynamics of a red blood cell [PDF]

arXiv, 2021
We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subjected to an external mechanical load. We carry out a detailed comparison between the {\it loading} (L) dynamics, following the imposition of the mechanical load on the RBC at rest, and the {\it relaxation} (R) dynamics, allowing the RBC to ...
arxiv  

Numerical Model for the Determination of Erythrocyte Mechanical Properties and Wall Shear Stress in vivo From Intravital Microscopy. [PDF]

, 2019
The mechanical properties and deformability of Red Blood Cells (RBCs) are important determinants of blood rheology and microvascular hemodynamics. The objective of this study is to quantify the mechanical properties and wall shear stress experienced by ...
Cabrales, Pedro, Jani, Vinay P, Jani, Vivek P, Lucas, Alfredo, Munoz, Carlos, Ortiz, Daniel, Williams, Alexander T, Yalcin, Ozlem   +7 more
core  

Erythrocyte Membrane in Hypertension

Japanese Heart Journal, 1979
The erythrocytes from stroke-prone SHR (SHRSP) were more fragile than those from stroke-resistant SHR (SHRSR) or Wistar-Kyoto (WK) rats at the age of 2 months. After the chronic administration of saline (1% NaCl in drinking water), blood pressure in both SHRSR and WK was elevated, but the membrane fragility was not changed.
Akira Ooshima, Yukio Yamori, Ryoichi Horie, Michiya Ohtaka, Yasuo Nara   +4 more
openaire   +3 more sources

Dual‐Nanoparticle Engineered Hydrogel Reverses Bicellular Oxidative Stress to Accelerate Diabetic Fracture Healing

Advanced Functional Materials, EarlyView.
CD105‐LNPs and PS‐LNPs can deliver α‐lipoic acid to bone marrow mesenchymal stem cells and bone marrow‐derived macrophages, reversing high glucose‐induced oxidative stress while enhancing osteogenesis and M2 polarization. Integrating both nanoparticles into glucose‐responsive hyaluronic acid hydrogel forms DLNPs@HA hydrogel, which accelerates diabetic ...
Yanzhi Zhao, Weixian Hu, Shengming Zhang, Yuheng Liao, Kangkang Zha, Chenyan Yu, Zhenhe Zhang, Wenqian Zhang, Bobin Mi, Faqi Cao, Guohui Liu, Wu Zhou   +11 more
wiley   +1 more source

LIBS-Based Detection of Antioxidant Elements in Seeds of Emblica officinalis [PDF]

, 2010
The aim of the study was to determine the effect of the elements of the extract of seed from Emblica officinalis on antioxidant enzymes and osmotic fragility of erythrocytes membrane in normal as well as streptozotocin-induced severely diabetic albino ...
Bicanic, D.D., Mehta, S., Rai, A.K., Rai, D.K., Rai, N.K., Rai, P.K., Sharma, B., Watal, G.   +7 more
core   +2 more sources

Membrane peroxidation and methemoglobin formation are both necessary for band 3 clustering: mechanistic insights into human erythrocyte senescence.

Biochemistry, 2013
Oxidative damage and clustering of band 3 in the membrane have been implicated in the removal of senescent human erythrocytes from the circulation at the end of their 120 day life span.
Nobuto Arashiki, Naoki Kimata, S. Manno, N. Mohandas, Y. Takakuwa   +4 more
semanticscholar   +1 more source