Results 71 to 80 of about 87,526 (316)

Contribution of plasma membrane lipid domains to red blood cell (re)shaping

Scientific Reports, 2017
Although lipid domains have been evidenced in several living cell plasma membranes, their roles remain largely unclear. We here investigated whether they could contribute to function-associated cell (re)shaping.
C. Leonard, L. Conrard, M. Guthmann, H. Pollet, M. Carquin, C. Vermylen, P. Gailly, P. Van Der Smissen, M. P. Mingeot-Leclercq, D. Tyteca   +9 more
doaj   +1 more source

Precision Photothermal Therapy at Mild Temperature: NIR‐II Imaging‐Guided, H2O2‐Responsive Stealth Nanobomb

Advanced Healthcare Materials, EarlyView.
The new generation nanobomb, termed the stealth nanobomb, is fabricated through self‐assembly using a polymeric carbon monoxide carrier (PLGA(CO)), small molecule near‐infrared‐active agents (2TT‐OC46B), and phospholipid polyethylene glycol (DSPE‐mPEG2000). The stealth nanobomb can circulate in the bloodstream and specifically target pancreatic cancer,
Gongcheng Ma, Qihang Ding, Yue Wang, Zhiwei Zhang, Yuding Zhang, Hui Shi, Lintao Cai, Ping Gong, Pengfei Zhang, Zhen Cheng, Jong Seung Kim   +10 more
wiley   +1 more source

Novel Less Toxic, Lymphoid Tissue‐Targeted Lipid Nanoparticles Containing a Vitamin B5‐Derived Ionizable Lipid for mRNA Vaccine Delivery

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
The top‐performing lipid nanoparticle, incorporating a novel ionizable lipid derived from vitamin B5, demonstrates high mRNA transfection efficiency, low toxicity, favorable stability, targeted delivery to lymphoid tissues, and high immunogenicity, showing promise as a carrier for mRNA vaccines for infectious diseases and cancer.
Soyeon Yoo, Muhammad Faisal, Seo‐Hyeon Bae, Kounghwa Youn, Hyo‐Jung Park, Sung Pil Kwon, Il Kwon Hwang, Jisun Lee, Hyeong Jun Kim, Jae‐Hwan Nam, Gyochang Keum, Eun‐Kyoung Bang   +11 more
wiley   +1 more source

Alteration in Membrane Protein, Antioxidant Status and Hexokinase Activity in Erythrocytes of Ccl4- Induced Cirrhotic Rats

Acta Medica Iranica, 2014
Several studies have shown that hepatocyte membrane composition changes in patients with cholestasis and cirrhosis. These alterations that are because of intracellular oxidative stress are supposed to be reflected in erythrocyte membrane. The aim of this
Amir Hossein Doustimotlagh, Ahmad Reza Dehpour, Mitra Nourbakhsh, Abolfazl Golestani   +3 more
doaj  

Avaliação das esterases sanguíneas na doença de Alzheimer.

Acta Médica Portuguesa, 1992
The aim of this work was to evaluate a possible correlation between erythrocyte acetylcholinesterase activity (AChE) and membrane fluidity expressed by fluorescence polarization of--1,6--diphenyl 1,3,5--hexatriene (DPH).
C Saldanha, T Quintão, C Garcia
doaj   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

Malaria Journal, 2019
Background Malaria disease commences when blood-stage parasites, called merozoites, invade human erythrocytes. Whilst the process of invasion is traditionally seen as being entirely merozoite-driven, emerging data suggests erythrocyte biophysical ...
Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M. Blagborough, Fiona Angrisano, Jake Baum   +7 more
doaj   +1 more source

Distribution and transbilayer movement of membrane cholesterol in erythrocyte of patients with essential hypertension

Grasas y Aceites, 1996
The participants were 12 healthy subjects, 12 normocholesterolaemic hypertensive and 12 hypercholesterolaemic hypertensive patients. Venous blood samples were collected in Trabajo ganador del VIII Premio Sociedad Andaluza de Medicina Interna. «Dr.
F. J. G. Muriana, J. Villar, V. Ruiz-Gutiérrez   +2 more
doaj   +1 more source

Vorticity‐Facilitated Platelet Aggregation: a High Expansion‐Ratio Stenotic Microfluidic Platform Unravels the Role of Complex Flow Dynamics in Arterial Thrombosis

Advanced Healthcare Materials, EarlyView.
This study reveals how vorticity—a swirling flow pattern—enhances platelet aggregation and thrombus formation in high‐shear conditions. Using a custom microfluidic model, it is shows that vorticity promotes vWF–GPIbα interactions and calcium signaling, providing new insights into thrombosis mechanobiology and informing safer blood‐contacting medical ...
Jianfang Ren, Nurul Aisha Zainal Abidin, Allan Sun, Rui Gao, Yuxin Chen, Arian Nasser, Zihao Wang, Yunduo Charles Zhao, Alexander Dupuy, Anna Waterhouse, Qian Peter Su, Daniele Vigolo, Mike Chia Lun Wu, Lining Arnold Ju   +13 more
wiley   +1 more source

Estudo da influência da angiografia com fluoresceína bissódica nos parâmetros hemorreológicos de doentes com diabetes mellitus.

Acta Médica Portuguesa, 1996
Chorioretinal angiography with fluorescein is an auxiliary method widely used in Ophthalmology which enables us to study the blood/humour and blood/retina/choroid interface.
L Sargento, L Zabala, T Gomes, C Saldanha, J Martins-Silva, P Souza-Ramalho   +5 more
doaj   +1 more source