Results 41 to 50 of about 448,913 (359)

Features of ionic transport processes in a model of arterial hypertension

Бюллетень сибирской медицины, 2018
Aim. To study the ionic mechanisms which underlie regulation contractile activity of vascular smooth muscles and the erythrocytes membrane potential from spontaneously hypertensive rats.Materials and methods. The effect of acetylcholine (ACX), 10 μM, and
A. V. Nosarev, Yu. G. Birulina, I. V. Petrova, I. V. Kovalev, S. V. Gusakova, L. V. Smagliy, E. S. Teslya, A. Yu. Shamanaev, E. V. Pushkina, M. A. Medvedev   +9 more
doaj   +1 more source

Storage of Erythrocytes Induces Suicidal Erythrocyte Death

Cellular Physiology and Biochemistry, 2016
Background/Aims: Similar to apoptosis of nucleated cells, red blood cells (RBC) can undergo suicidal cell death - called eryptosis. It is characterized by cell shrinkage and phosphatidylserine translocation. Eryptosis is triggered by an increase of intracellular calcium concentration due to activation of nonselective cation channels.
Lang, Elisabeth, Pozdeev, Vitaly I, Xu, Haifeng C, Shinde, Prashant V, Behnke, Kristina, Hamdam, Junnat M, Lehnert, Erik, Scharf, Rüdiger E, Lang, Florian, Häussinger, Dieter, Lang, Karl S., Lang, Philipp A   +11 more
openaire   +4 more sources

A mathematical model of fibrinogen-mediated erythrocyte–erythrocyte adhesion

Communications Biology, 2023
AbstractErythrocytes are deformable cells that undergo progressive biophysical and biochemical changes affecting the normal blood flow. Fibrinogen, one of the most abundant plasma proteins, is a primary determinant for changes in haemorheological properties, and a major independent risk factor for cardiovascular diseases.
Catarina S. Lopes, Juliana Curty, Filomena A. Carvalho, A. Hernández-Machado, Koji Kinoshita, Nuno C. Santos, Rui D. M. Travasso   +6 more
openaire   +7 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Mathematical model of detection of intra-erythrocyte pathologies using optoacoustic method

Biomedical Photonics, 2018
Malaria causes a serious health problem in the tropical and subtropical regions of the globe. In many cases, the consequences of this disease are fatal. Therefore, a simple, fast, accurate and affordable diagnostic system for the early detection of this ...
D. A. Kravchuk
doaj   +1 more source

Study of the joint action of coenzyme Q10 and royal jelly on the hematological and spirometric indicators in the elite athletes

Спортивная медицина: наука и практика, 2020
Objective: to study the effects of royal jelly and coenzyme Q10 administered with food on the number of hematological and spirometric indicators in elite swimmers in precompetitive period. Materials and methods: 16 highly qualified athletes at the age of
S. V. Kopylova, A. N. Ovchinnikov, M. A. Shabalin, A. V. Deryugina, V. N. Krylov, V. G. Kuzmin, D. I. Voronin, O. V. Shabalina   +7 more
doaj   +1 more source

The effect of silver-containing sorbent on red blood cells during hemosorption: an in vitro study

Сибирский научный медицинский журнал, 2022
The aim of the study was to investigate the influence of the original porous silver–containing sorbent on the morphofunctional parameters of red blood cells during in vitro hemoperfusion. Material and methods.
L. N. Rachkovskaya, A. A. Smagin, V. V. Nimaev, A. Yu. Demura, E. E. Rachkovsky, E. S. Yastrebova, V. P. Maltsev, M. A. Korolev, A. Yu. Letyagin   +8 more
doaj   +1 more source

On the Equilibrium Shape of Erythrocytes

, 2015
It is shown that the model proposed by Canham quantitatively describes the observed biconcave shape of human ...
Marchenko, V. I., Podolyak, E. R.
core   +1 more source

Morphological analysis of cells by means of an elastic metric in the shape space [PDF]

, 2020
Shape analysis is of great importance in many fields, such as computer vision, medical imaging, and computational biology. This analysis can be performed considering shapes as closed planar curves in the shape space.
Epifanio, Irene, Gual-Arnau, Ximo, Herold-Garcia, Silena   +2 more
core   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source