Results 51 to 60 of about 241,660 (316)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

In Vitro Measurement of the Elastic Properties of the Native Red Blood Cell Membrane

Общая реаниматология, 2015
Objective: to develop a procedure to image native cells in a physiological medium and to measure the local stiffness of fixed red blood cell membranes in liquid in vitro experiments.Material and methods.
V. A. Sergunova, E. K. Kozlova, E. A. Myagkova, A. M. Chernysh   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

"Plasmodium falciparum var" Gene Expression Dynamics and its Relevance in Malaria Disease in Children from Papua New Guinea [PDF]

, 2005
Malaria is a tremendous global public health problem. While especially hitting the poorest countries in the world, malaria elicits each year 300 million febrile illnesses and up to 1 million deaths. Widespread drug resistances, climatic changes, but also
Kästli, Mirjam Elisabeth
core   +1 more source

Phenotypic features of erythrocytes and activity of erythropoiesis in cardiosurgical patients with various degree of postperfusion hemolysis manifestation

Бюллетень сибирской медицины, 2012
A study of phenotypic characteristics of erythrocytes and indicators of activity of erythropoiesis in cardiosurgical patients with moderated (40 patients) and expressed (18 patients) hemolysis after coronary artery bypass grafting in conditions of ...
V. V. Novitsky, S. P. Chumakova, O. I. Urazova, V. M. Shipulin, O. A. Khokhlov, Yu. V. Kolobovnikova   +5 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythrocyte complement receptor 1 (CR1) expression level is not associated with polymorphisms in the promoter or 3' untranslated regions of the CR1 gene

, 2006
Complement receptor 1 (CR1) expression level on erythrocytes is genetically determined and is associated with high (H) and low (L) expression alleles identified by a HindIII restriction fragment-length polymorphism (RFLP) in intron 27 of the CR1 gene ...
Cockburn, I A, Rowe, J A; id_orcid, J. A. Rowe, I. A. Cockburn   +3 more
core   +1 more source

Examining Erythrocytes as Potential Blood Biomarkers for Autism Spectrum Disorder: Their Relationship to Symptom Severity and Adaptive Behavior

Biomedicines
Background: Multiple research teams have documented various abnormalities in erythrocyte properties in children with autism spectrum disorder (ASD) compared with neurotypical individuals.
Tomas Jasenovec, Dominika Radosinska, Ivan Belica, Barbara Raskova, Angelika Puzserova, Norbert Vrbjar, Jana Radosinska   +6 more
doaj   +1 more source

MORPHOLOGICAL CHARACTERISTICS OF ERYTHROCYTES AT UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA IN CHILDREN

Педиатрическая фармакология, 2014
Examination of 73 children of 8–12 years of age was conducted in order to study morphological characteristics of erythrocytes at undifferentiated connective tissue dysplasia (UCTD). Scanning electron microscopy revealed significant alterations of surface
D. A. Ponomareva, T. A. Nagayeva, I. I. Balasheva, N. M. Shevtsova   +3 more
doaj   +1 more source

Interactions Between Aerolysin, Erythrocytes, and Erythrocyte Membranes [PDF]

Infection and Immunity, 1975
Aerolysin, a hemolytic and lethal exotoxin of Aeromonas hydrophila , was analyzed for amino acids. Assuming 8 histidine residues/mol, the purified toxic protein has, by summation, a molecular weight of 49,000, a value in agreement with earlier estimates by other methods.
A W, Bernheimer, L S, Avigad, G, Avigad
openaire   +2 more sources