Results 61 to 70 of about 448,913 (359)

A bioinformatics screen identifies TCF19 as an aggressiveness‐sustaining gene in prostate cancer

Molecular Oncology, EarlyView.
Gene expression meta‐analysis in multiple prostate cancer patient cohorts identifies Transcription factor 19 (TCF19) as an aggressiveness‐sustaining gene with prognostic potential. TCF19 is a gene repressed by androgen signaling that sustains core cancer‐related processes such as vascular permeability or tumor growth and metastasis.
Amaia Ercilla, Jana R. Crespo, Saioa Garcia‐Longarte, Marta Fidalgo, Sara del Palacio, Natalia Martin‐Martin, Onintza Carlevaris, Ianire Astobiza, Sonia Fernández‐Ruiz, Marc Guiu, Laura Bárcena, Isabel Mendizabal, Ana M. Aransay, Mariona Graupera, Roger R. Gomis, Arkaitz Carracedo   +15 more
wiley   +1 more source

Состояние периферического звена эритрона при дисплазии соединительной ткани у детей

Бюллетень сибирской медицины, 2008
Status of peripheral blood erythrocytes was studied in 51 children aged 8 to 12 years with connective tissue dysplasia (CTD). There were re vealed modifications superficial architectonics of red cells, decreased thiol groups and lipoprotein complex ...
D. A. Ponomaryova
doaj   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

ИЗМЕНЕНИЯ ОПТИЧЕСКИХ ПАРАМЕТРОВ КРОВИ У ПАЦИЕНТОВ С ЦИРРОЗАМИ ПЕЧЕНИ РАЗЛИЧНОЙ СТЕПЕНИ ТЯЖЕСТИ

Архивъ внутренней медицины, 2014
The optical parameters of red blood cells and serum from patients with different classes of liver cirrhosis by Child–Pugh were examined by atomic force microscopy, dielectrophoresis, spectral ellipsometry, terahertz and Raman-spectroscopy.
М. В. Кручинина, М. И. Воевода, С. А. Курилович, А. А. Громов, В. А. Баум, Е. Г. Немцова, Е. В. Логвиненко, Н. А. Ковалькова, В. М. Генералов, Б. Н. Зайцев, В. Н. Кручинин, С. В. Рыхлицкий, Б. А. Князев, В. В. Герасимов, А. Г. Покровский, В. О. Пустыльняк, С. В. Чересиз, Г. Р. Сакаева, А. И. Корбут, В. Д. Анцыгин   +19 more
doaj   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

An Immunomodulatory Zinc‐Alum/Ovalbumin Nanovaccine Boosts Cancer Metalloimmunotherapy Through Erythrocyte‐Assisted Cascade Immune Activation

Advanced Science
Cancer therapeutic vaccines are powerful tools for immune system activation and eliciting protective responses against tumors. However, their efficacy has often been hindered by weak and slow immune responses.
Jing Zhao, Lingxiao Zhang, Pin Li, Shanbiao Liu, Shiyi Yu, Zheng Chen, Mingjian Zhu, Shangzhi Xie, Daishun Ling, Fangyuan Li   +9 more
doaj   +1 more source

Homogeneous Deformation of Native Erythrocytes During Long-Term Storage

Общая реаниматология, 2019
Purpose of the study — to evaluate biomechanical regularities of deep deformation of native erythrocytes’ membranes during long-term (up to 32 days) storage of erythrocyte suspension.Materials and methods.
E. A. Manchenko, E. K. Kozlova, V. A. Sergunova, A. M. Chernysh   +3 more
doaj   +1 more source

Imaging morphological details and pathological differences of red blood cells using tapping-mode AFM [PDF]

, 2004
The surface topography of red blood cells (RBCs) was investigated under nearphysiological conditions using atomic force microscopy (AFM). An immobilization protocol was established where RBCs are coupled via molecular bonds of the membrane glycoproteins ...
Berg, Jörg, Ebner, A., Gruber, Hermann J., Hinterdorfer, Peter, Huss, Ralf, Kamruzzahan, A. S. M., Kienberger, Ferry, Rankl, Christian, Stroh, Cordula M., Zhu, Rong   +9 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Insights on the Mechanisms of the Protective Action of Naringenin, Naringin and Naringin Dihydrochalcone on Blood Cells in Terms of Their Potential Anti-Atherosclerotic Activity

Molecules
Atherosclerosis is caused by injury to the blood arteries and progressive oxidative stress. Blood cells play an important role in its development; thus, their protection is important.
Teresa Kaźmierczak, Sylwia Cyboran-Mikołajczyk, Natalia Trochanowska-Pauk, Tomasz Walski, Paulina Nowicka, Dorota Bonarska-Kujawa   +5 more
doaj   +1 more source