Results 41 to 50 of about 8,414 (207)

Cardiovascular Plasticity and Adaptation of High‐Altitude Birds and Mammals

Integrative Zoology, EarlyView.
This schematic depicts the cardiovascular adaptations of mammals and birds to high‐altitude hypoxia. It highlights key phenotypic changes in oxygen transport and cardiac responses, driven by molecular mechanisms including transcriptional regulation and genetic modifications.
Huishang She, Yanhua Qu
wiley   +1 more source

Erythrocytosis due to PHD2 Mutations: A Review of Clinical Presentation, Diagnosis, and Genetics

Case Reports in Hematology, 2016
The association of mutations in the PHD2 protein of the hypoxia-sensing pathway and erythrocytosis has only been established in the last decade. Here we report the case of a novel PHD2 gene mutation in a patient with erythrocytosis and summarize all ...
Rachel Wilson, Nausheen Syed, Prabodh Shah   +2 more
doaj   +1 more source

Enalaprilat and losartan decrease erythroid precursors frequency in cells from patients with polycythemia vera

Hematology, 2023
Objective: Polycythemia Vera (PV) is a myeloproliferative neoplasm characterized by the overproduction of red blood cells. First-line therapies are directed at lowering hematocrit levels. After the discovery of a mutation in the Janus kinase 2 (JAK2V617F)
Angela Bozza, Martina Bernardi, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Giuseppe Astori   +5 more
doaj   +1 more source

Current Approaches to Support Patients to Withdraw From Image and Performance Enhancing Drugs

Clinical Endocrinology, EarlyView.
ABSTRACT Image and performance‐enhancing drugs (IPEDs) include agents such as androgens, growth hormone, and erythropoietin, which are used to enhance appearance and physical performance. Androgens, also known as anabolic‐androgenic steroids (AAS), are the most used IPEDs worldwide.
Elizabeth Hyams, Bonnie Grant, Richard Quinton, Channa N. Jayasena   +3 more
wiley   +1 more source

Comprehensive in silico and functional studies for classification of EPAS1/HIF2A genetic variants identified in patients with erythrocytosis

Haematologica, 2023
Gain-of-function mutations in the EPAS1/HIF2A gene have been identified in patients with hereditary erythrocytosis that can be associated with the development of paraganglioma, pheochromocytoma and somatostatinoma.
Valéna Karaghiannis, Darko Maric, Céline Garrec, Nada Maaziz, Alexandre Buffet, Loïc Schmitt, Vincent Antunes, Fabrice Airaud, Bernard Aral, Amandine Le Roy, Sébastien Corbineau, Lamisse Mansour-Hendili, Valentine Lesieur, Antoine Rimbert, Fabien Laporte, Marine Delamare, Minke Rab, Stéphane Bézieau, Bruno Cassinat, Frédéric Galacteros, Anne-Paule Gimenez-Roqueplo, Nelly Burnichon, Holger Cario, Richard van Wijk, Celeste Bento, François Girodon, David Hoogewijs, Betty Gardie   +27 more
doaj   +1 more source

Cardiometabolic Protein Profile Changes During Gender‐Affirming Hormone Therapy: A Prospective Clinical Study

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Cardiovascular disease (CVD) risk is elevated in transgender individuals during gender‐affirming hormone therapy (GAHT) with expected different mechanisms between T‐ and E2‐based GAHT. We investigated prospective changes in cardiometabolic proteins relating to complement, inflammation, and transport during GAHT.
Emilie Bukh Madsen, Louise Lehmann Christensen, Sara Ravn Bach, Louise Skøttrup Christiansen, Mathilde Kamp Nørlund, Tine Taulbjerg Kristensen, Guy T'Sjoen, Anne Pernille Hermann, Camilla Viola Buskbjerg Palm, Jan Frystyk, Marianne Skovsager Andersen, Martin Overgaard, Dorte Glintborg   +12 more
wiley   +1 more source

Weight Regain After Incretin Treatment: The Lean Mass Deficit Hypothesis and a Role for Testosterone Combination Therapy in Men

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), dual glucose‐dependent insulinotropic polypeptide (GIP)/GLP‐1RA and triple (GIP)/GLP‐1RA/glucagon agonists achieve placebo‐subtracted weight loss of 15% to 22%. Their long‐term value depends on how well the weight loss is maintained and on the composition of weight loss, not only
Michael Zitzmann, Zsolt Bosnyak, Richard Jones, Monica Caliber   +3 more
wiley   +1 more source

A rare case of renal oncocytoma associated with erythrocytosis: case report

BMC Urology, 2006
Background Oncocytomas are benign tumors of the kidney that are usually diagnosed postoperatively due to differential diagnostic problems from renal cell carcinoma.
Tahmatzopoulos Anastasios, Tzakas Konstantinos, Radopoulos Demetrios   +2 more
doaj   +1 more source

Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis

Experimental Physiology, EarlyView.
Abstract High‐altitude hypoxia elicits several profound physiological responses, including substantial increases in muscle sympathetic nerve activity (MSNA); however, the association of this heightened MSNA with cardiovascular and cerebrovascular haemodynamics remains unclear in lowlanders and indigenous highlander populations.
Ty J. A. MacDonald, Jenna C. McCrone, Christabel Osei‐Boateng, Connor D. Wideman, Samantha L. Tsioros, Joshua C. Tremblay, Alexander Patrician, Connor A. Howe, Geoff B. Coombs, Benjamin S. Stacey, Lydia L. Simpson, Mike Stembridge, Craig D. Steinback, Jonathan P. Moore, Travis D. Gibbons, Ryan L. Hoiland, Francisco Villafuerte, Gilbert Moralez, Philip N. Ainslie, Michael M. Tymko   +19 more
wiley   +1 more source

Two new mutations in the HIF2A gene associated with erythrocytosis

, 2012
Congenital or familial erythrocytosis/polycythemia can have many causes, and an emerging cause is genetic disruption of the oxygen-sensing pathway that regulates the Erythropoietin (EPO) gene.
Chung, Yu Jin, Percy, Melanie J., Lee, Frank S., Hoffbrand, A. Victor, Mcmullin, Mary Frances, Lappin, Terrance R.J., Fonseca, Guilherme H.H., Harrison, Claire, Santos, Paulo C.J.L., Gualandro, Sandra F.M., Pereira, Alexandre C., Dinardo, Carla L., Mercieca, Jane   +12 more
core   +1 more source