Results 61 to 70 of about 8,414 (207)

Metabolic Profiling Combined With Machine Learning for Assessing Clonal Hematopoiesis Status in Chronic Immune Thrombocytopenia: An Exploratory Analysis

MedComm, Volume 7, Issue 11, November 2026.
Clonal hematopoiesis (CH) may contribute to immune thrombocytopenia (ITP). Among 1817 patients with chronic ITP, CH occurred in 10.8%. Plasma metabolomes of 539 patients were profiled by untargeted LC‐MS/MS, revealing 14 metabolites distinguishing CH from non‐CH. Logistic regression combining these metabolites with sex, age, and platelet count achieved
Jia Chen, Qing Wen, Ting Sun, Xiaofan Liu, Feng Xue, Wei Liu, Rongfeng Fu, Mankai Ju, Xinyue Dai, Ying Chi, Wentian Wang, Renchi Yang, Yunfei Chen, Lei Zhang   +13 more
wiley   +1 more source

Erythrocytosis in children and adolescents-classification, characterization, and consensus recommendations for the diagnostic approach

, 2013
During recent years, the increasing knowledge of genetic and physiological changes in polycythemia vera (PV) and of different types of congenital erythrocytosis has led to fundamental changes in recommendations for the diagnostic approach to patients ...
McMullin, Mary Frances,, Schwarz, Jiri,, Cario, Holger,, Hermouet, Sylvie, Åström, Maria,, Hussein, Kais,, Bento, Celeste,, Frances McMullin, Mary, Pospisilova, Dagmar, Schwarz, Jiri, Hermouet, Sylvie,, Cario, Holger, Hussein, Kais, Aström, Maria, Pospisilova, Dagmar,, Percy, Melanie J.,, Percy, Melanie J, Bento, Celeste   +17 more
core   +1 more source

Dorsal ischaemic myelopathy in a dog: A case of unilateral, focal predominantly sensory loss

Veterinary Record Case Reports, Volume 14, Issue 4, November 2026.
Abstract A 3‐year‐3‐month‐old, neutered, male Great Dane was presented with peracute left hindlimb monoparesis. Although voluntary movement was present, the dog was effectively non‐ambulatory due to its size. Proprioception, nociception and spinal reflexes were absent in the left hindlimb, localising the lesion to a left L4–S1 myelopathy.
Alexandra Ayoub, Ana Maria Oliveira, Nicholas Goody, Aran Nagendran   +3 more
wiley   +1 more source

Clinical features of acquired erythrocytosis: Low levels of serum erythropoietin in a subset of non‐neoplastic erythrocytosis patients

Cancer Medicine, 2023
Background Acquired erythrocytosis can be classified into polycythemia vera (PV) and non‐neoplastic erythrocytosis (NNE). The vast majority of PV patients harbor JAK2 mutations, but differentiating JAK2 mutation‐negative PV from NNE is challenging due to
Yosuke Mori, Marito Araki, Soji Morishita, Misa Imai, Yoko Edahiro, Masafumi Ito, Tomonori Ochiai, Shuichi Shirane, Yoshinori Hashimoto, Hajime Yasuda, Jun Ando, Miki Ando, Norio Komatsu   +12 more
doaj   +1 more source

What anabolic–androgenic steroids reveal about the limits of current harm reduction models

Addiction, Volume 121, Issue 11, Page 2861-2869, November 2026.
Abstract Background Harm reduction has largely been shaped by responses to psychoactive drug use where the most urgent harms are acute. These models focus on overdose, blood‐borne viruses, and rapid‐onset toxicity related harms. When applied wholesale to anabolic–androgenic steroids (AAS), they obscure the distinctive pharmacology, consumer typologies,
Timothy Piatkowski, Jason M. Nagata, Suzanne Nielsen   +2 more
wiley   +1 more source

The Effect of Polycythemia Vera on Pregnancy Complications. The Analysis of an American Population Database With Over 9 Million Deliveries

European Journal of Haematology, Volume 117, Issue 5, Page 1249-1257, November 2026.
ABSTRACT Objectives Polycythemia Vera (PV) is characterized by overproduction of erythrocytes, leading to a hypercoagulable state. Evidence regarding associations between PV and pregnancy outcomes is limited. The aim of our study was to provide robust evidence regarding the prevalence of pregnancy complications in women with PV.
Noah Margolese, Sarah Al‐Rayes, Shaonie Ton‐Leclerc, Ahmad Badeghiesh, Haitham Baghlaf, Michael H. Dahan   +5 more
wiley   +1 more source

POEMS Syndrome: 2026 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, Volume 101, Issue 10, Page 2632-2651, October 2026.
ABSTRACT Disease Overview POEMS syndrome is a life‐threatening syndrome due to an underlying plasma cell neoplasm. The major criteria for the syndrome are polyneuropathy, clonal plasma cell disorder (PCD), sclerotic bone lesions, elevated vascular endothelial growth factor, and the presence of Castleman disease.
Angela Dispenzieri
wiley   +1 more source

Gene panel sequencing improves the diagnostic work-up of patients with idiopathic erythrocytosis and identifies new mutations

Haematologica, 2016
Erythrocytosis is a rare disorder characterized by increased red cell mass and elevated hemoglobin concentration and hematocrit. Several genetic variants have been identified as causes for erythrocytosis in genes belonging to different pathways including
Carme Camps, Nayia Petousi, Celeste Bento, Holger Cario, Richard R. Copley, Mary Frances McMullin, Richard van Wijk, Peter J. Ratcliffe, Peter A. Robbins, Jenny C. Taylor   +9 more
doaj   +1 more source

CO‐Rebreathing in Essential Thrombocythemia and Polycythemia Vera. A Revival of an Old Methodology to Improve Diagnosis and Phlebotomy Decisions

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT The diagnostic landscape for the Philadelphia‐negative myeloproliferative neoplasms (MPNs), particularly in distinguishing Essential Thrombocythemia (ET) from Polycythemia Vera (PV), is compromised. The gold standard for diagnosing PV—measurement of red cell mass (RCM) by radioisotope dilution—has been largely abandoned, leading to widespread ...
Hans C. Hasselbalch, Morten Kranker Larsen, Lea Løffler, Camilla Andersen, Isabella Davidsen, Mette Grymer Jensen, Jonas Bechlund, Lasse Kjær, Vibe Skov, Henning Bay Nielsen, Carsten Lundby   +10 more
wiley   +1 more source

Amyloid‐Forming Amylin Secreted by the Pancreas Promotes Hypoxia‐Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Human amylin is secreted from the pancreas of HIP rats and is amyloidogenic, forming aggregates systemically. In comparison with age‐matched control (WT), hyperglycemic (UCD) and amylin knockout rats (AKO), HIP rats showed increased hypoxia‐inducible factors (HIF‐1/2) in heart and liver, alongside alterations in mitochondrial electron transfer system ...
Alice E. Knapton, Nirmal Verma, Deepak Kotiya, Alice P. Sowton, Benjamin D. Thackray, Lorenz M. W. Holzner, Paula M. Darwin, Sanda Despa, Florin Despa, Andrew J. Murray   +9 more
wiley   +1 more source