Results 81 to 90 of about 187,553 (368)

Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model [PDF]

, 2016
A severe application of stress on articular cartilage can initiate a cascade of biochemical reactions that can lead to the development of osteoarthritis.
Ayati, Bruce P., Brouillette, Marc J., Kapitanov, Georgi I., Martin, James A., Wang, Xiayi   +4 more
core   +3 more sources

Model‐Informed Drug Development for Daprodustat Supports the Design of Individualized Dosing Regimens in Chronic Kidney Disease Patients With Anemia

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) played a crucial role in the successful development and regulatory approval of daprodustat, a novel oral hypoxia‐inducible factor prolyl hydroxylase (HIF‐PHI) inhibitor aimed at treating anemia in chronic kidney disease patients.
Kelly M. Mahar, Shuying Yang, Brendan Johnson, Sandra A.G. Visser, Paul van den Berg, Martijn van Noort, Teun M. Post   +6 more
wiley   +1 more source

Increased preoperative collection of autologous blood with recombinant human erythropoietin therapy in tertiary care hospitals of Jammu

Asian Journal of Transfusion Science, 2013
Introduction: To study whether the administration of recombinant human erythropoietin increases the amount of autologous blood that can be collected before orthopaedic surgery.
Kumkum Sharma, Sumit B Sharma, Imran A Pukhta, Amit B Sharma, Abdul Q Salaria   +4 more
doaj   +1 more source

Synergistic renoprotective effects of sesame oil and erythropoietin on ischemic kidney injury after renal transplantation

AMB Express, 2020
In this study, we evaluated the combined therapeutic efficacy of erythropoietin (a hematopoietic hormone produced by the fetal liver and kidney in response to inflammation and apoptosis) and sesame oil (from Sesamum indicum L.) on ischemic kidney injury ...
Liyu Ye, Fang Xiao, Jijun Xie, Lingling Feng, Zhangjun Tang, E. Chen, Chuchu Chen, Bowen Xu, Ronghai Deng   +8 more
doaj   +1 more source

Modelling hematopoiesis mediated by growth factors with applications to periodic hematological diseases [PDF]

, 2006
Hematopoiesis is a complex biological process that leads to the production and regulation of blood cells. It is based upon differentiation of stem cells under the action of growth factors.
Adimy, Mostafa, Crauste, Fabien, Ruan, Shigui   +2 more
core   +5 more sources

Erythropoietin guides multipotent hematopoietic progenitor cells toward an erythroid fate

Journal of Experimental Medicine, 2014
Erythropoietin suppresses non-erythroid cell fate options to induce an erythroid lineage bias at all lineage bifurcations between HSCs and committed erythroid progenitors.
A. Grover, E. Mancini, Susan Moore, A. Mead, D. Atkinson, K. D. Rasmussen, D. O’Carroll, S. Jacobsen, C. Nerlov   +8 more
semanticscholar   +1 more source

Detection of a Single Microdose of Testosterone and Recombinant EPO in Healthy Volunteers

Drug Testing and Analysis, EarlyView.
Exogenous T was detected with IRMS regardless of T/E elevation—high serum T indicative for IRMS. rhEPO was detected in urine for 72 h in ITP and CP, and Tasso showed less sensitivity than previous DBS devices tested. ABSTRACT Doping with testosterone (T) and erythropoietin (EPO) in low doses (micro‐doping) is a challenge to detect.
Carmel Heiland, Oscar Hopcraft, Mats Johanson, Anton Pohanka, Mikael Lehtihet, Lena Ekström   +5 more
wiley   +1 more source

Effect of surface hydrophobicity of therapeutic protein loaded in polyelectrolyte nanoparticles on transepithelial permeability

Acta Pharmaceutica, 2018
Oral delivery of protein drugs is greatly limited by low hydrophobicity, an important determinant for intestinal epithelial permeation and bioavailability.
Miklavžin Ana, Cegnar Mateja, Kerč Janez, Kristl Julijana   +3 more
doaj   +1 more source

Effects of glycerol and creatine hyperhydration on doping-relevant blood parameters [PDF]

, 2012
Glycerol is prohibited as an ergogenic aid by the World Anti-Doping Agency (WADA) due to the potential for its plasma expansion properties to have masking effects.
Catherine Hambly, Chris Easton, Craig, Dalia Malkova, Dill, Easton, Fjeld, Freund, Gore, Green, Hagan, Harris, Haugland, Holland, John R. Speakman, Karsten Koehler, Kavouras, Kilduff, Latzka, Lukas Beis, Lyons, Morkeberg, Pantazis Takas, Parisotto, Polyviou, Riedesel, Schumacher, Sharpe, Sommer, Sottas, Speakman, Thelma P. Polyviou, Vandenberghe, Yannis P. Pitsiladis   +33 more
core   +3 more sources

Estimation of Plasma Volume by Machine Learning to Improve the Interpretation of the Athlete Biological Passport

Drug Testing and Analysis, EarlyView.
A new machine learning model for plasma volume (PV) estimation was applied within the ABP framework. PV estimation was applied through visual displays or corrected ABP thresholds. With a favorable assessment from ABP experts, these results support further application of this model in the presence of specific confounding factors.
Bastien Krumm, Laura Lewis, Jakob Mørkeberg, Yorck Olaf Schumacher, Giuseppe d'Onofrio, Basile Moreillon, Raphael Faiss   +6 more
wiley   +1 more source