Results 41 to 50 of about 60,176 (280)

The EPO-FGF23 Signaling Pathway in Erythroid Progenitor Cells: Opening a New Area of Research

Frontiers in Physiology, 2019
We provide an overview of the evidence for an erythropoietin-fibroblast growth factor 23 (FGF23) signaling pathway directly influencing erythroid cells in the bone marrow.
Annelies J. van Vuren, Carlo A. J. M. Gaillard, Michele F. Eisenga, Richard van Wijk, Eduard J. van Beers   +4 more
doaj   +1 more source

Darbepoetin alfa given every 1 or 2 weeks alleviates anaemia associated with cancer chemotherapy. [PDF]

, 2002
In part A of this study, patients were randomised to cohorts receiving darbepoetin alfa at doses of 0.5 to 8.0 m.c.g x kg(-1) x wk(-1) or to a control group receiving epoetin alfa at an initial dose of 150 U x kg(-1) three times weekly.
Armstrong, S, Colowick, AB, Glaspy, JA, Jadeja, JS, Justice, G, Kessler, J, O'Byrne, J, Richards, D, Rossi, G, Schwartzberg, L, Tchekmedyian, NS   +10 more
core   +2 more sources

Congenital Familial Erythrocytosis: A case report with a review

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Familial erythrocytosis is a heterogeneous group of hereditary conditions with an increased total RBC volume. The disease occurs in a familial pattern and follows a relatively benign course.
Muqtasid Ahmad Kamili, Ishrat Hussain Dar, Showkat Hussain Dar, Mohammed Ismail Quadri, Hardeep Singh Wazir, Aijaz Arshad Bhat   +5 more
doaj   +2 more sources

Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis [PDF]

, 2017
Vitamin A is an essential micronutrient throughout life. Its physiologically active metabolite retinoic acid (RA), acting through nuclear retinoic acid receptors (RARs), is a potent regulator of patterning during embryonic development, as well as being ...
Adamo, Ana Cañete, Arguello, Cardoso, Dary, De Luca, Elena Cano, Gebremedhin, Gerster, Grande, Guo, Haussler, Kuwata, Lo-Coco, McLaren, Nervi, North, Ottersbach, O’Donnell, Ramón Muñoz-Chápuli, Rita Carmona, Ross, Testa, West   +23 more
core   +4 more sources

Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice. [PDF]

PLoS ONE, 2017
Tmprss6-mutated mask mice display iron deficiency anemia and high expression of hepcidin. The aim of the study was to determine the effect of erythropoietin administration on proteins participating in the control of iron homeostasis in the liver and ...
Jana Frýdlová, Zuzana Rychtarčíková, Iuliia Gurieva, Martin Vokurka, Jaroslav Truksa, Jan Krijt   +5 more
doaj   +1 more source

Biomarkers and low risk in heart failure. Data from COACH and TRIUMPH [PDF]

, 2015
Aim Traditionally, risk stratification in heart failure (HF) emphasizes assessment of high risk. We aimed to determine if biomarkers could identify patients with HF at low risk for death or HF rehospitalization.
Anand, Behnes, Boer, Boer, Boer, Boer, Chen, Cheng, Christenson, De Boer, DeLong, Edelmann, Fonarow, Fonarow, Gheorghiade, Grafft, Jaarsma, Jaarsma, Jencks, Kimmenade, Levy, Lok, Maisel, Marti, Masson, Meijers, Meijers, Motiwala, O'Brien, O'Connor, Ouwerkerk, Peacock, Pencina, Phillips, Postmus, Rahimi, Ruifrok, Salah, Setoguchi, Sharma, Stewart, Troughton, Vazquez, Velde, Veldhuisen, Yancy, Yu   +46 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Lack of effect of the human GM-CSF analog E21R on the survival of primary human acute myeloid leukemia cells [PDF]

, 2004
The granulocyte-macrophage colony-stimulating factor (GM-CSF) analog E21R binds to the GM-CSF receptor complex with low affinity and acts as a competitive antagonist.
Grandage, V.L., Jakupovic, I., Khwaja, A., Linch, D.C.   +3 more
core   +1 more source

Detection and isolation of the erythropoietin receptor using biotinylated erythropoietin [PDF]

Blood, 1990
Abstract Procedures have been developed to label human erythropoietin (Ep) with biotin to detect and isolate the Ep-receptor. The labeling method used the abundant carbohydrate groups on Ep and resulted in biologically active biotin-Ep (b-Ep) containing 8 to 10 biotins per Ep molecule.
A W, Wognum, P M, Lansdorp, R K, Humphries, G, Krystal   +3 more
openaire   +3 more sources

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source